Title Prodrugs : challenges and rewards / Valentino J. Stella [and others], editors

Published New York, NY : Springer : AAPS Press, ©2007

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Description 1 online resource (2 volumes) : illustrations Series Biotechnology : pharmaceutical aspects ; v. 5 Biotechnology (Arlington, Va.) ; v. 5. Contents Cover -- Contents: Part I -- Preface -- 1.1 A Case for Prodrugs -- 2.1.1 Prodrug Approaches to Enhancing the Oral Delivery of Poorly Permeable Drugs -- 2.1.2 Topical Delivery Using Prodrugs -- 2.1.3 Prodrug Approaches to Ophthalmic Drug Delivery -- 2.2.1 Oral Delivery -- 2.2.2 Prodrugs and Parenteral Drug Delivery -- 2.3.1 Poly (ethylene glycol) Prodrugs: Altered Pharmacokinetics and Pharmacodynamics -- 2.3.2 Prodrugs to Reduce Presystemic Metabolism -- 2.4.1 Small Molecules -- 2.4.2 Controlled Release -- Macromolecular Prodrugs -- 2.4.3 Proenzymes -- 2.5.1 Targeting: Theoretical and Computational Models -- 2.5.2 Cancer Small Molecules -- 2.5.3 Monoclonal Antibody Drug Conjugates for Cancer Therapy -- 2.5.4 Antibody-Directed Enzyme Prodrug Therapy (ADEPT) -- 2.5.5 Prodrugs for Liver-Targeted Drug Delivery -- 2.5.6 Prodrug Approaches for Drug Delivery to the Brain -- 2.5.7 Lymphatic Absorption of Orally Administered Prodrugs -- 2.5.8 Colonic Delivery -- Index -- Cover -- Contents: Part II -- Preface -- 3.1 Prodrugs of Carboxylic Acids -- 3.2 Prodrugs of Alcohols and Phenols -- 3.3 Prodrugs of Amines -- 3.4 Prodrugs of Amides, Imides and Other NH Acidic Compounds -- 3.5 Prodrugs of Benzamidines -- 3.6 Prodrugs of Phosphonates, Phosphinates, and Phosphates -- 3.7 Functional Group Approaches to Prodrugs: Functional Groups in Peptides -- 3.8 Macromolecular Prodrugs of Small Molecules -- 3.9 Miscellaneous Functional Groups -- 4.1.1 Prodrugs: Absorption, Distribution, Metabolism, Excretion (ADME) Issues -- 4.1.2 Formulation Challenges of Prodrugs -- 4.2.1 Safety Assessment of Prodrugs -- 4.2.2 Toxicological Issues with Pivalate Prodrugs -- 5.1 Adefovir Dipivoxil: An Oral Prodrug of Adefovir -- 5.2 Amifostine (Ethyol174;) -- 5.3 Capecitabine: A Prodrug of 5-Fluorouracil -- 5.4 Cefditoren Pivoxil: An Oral Prodrug of Cefditoren -- 5.5 Cefuroxime Axetil: An Oral Prodrug of Cefuroxime -- 5.6 Clindamycin 2-Phosphate: A Prodrug of Clindamycin -- 5.7 Enalapril: A Prodrug of Enalaprilat -- 5.8 Famciclovir: A Prodrug of Penciclovir -- 5.9 Fosamprenavir: A Prodrug of Amprenavir -- 5.10 Fosinopril -- 5.11 Fosphenytoin: A Prodrug of Phenytoin -- 5.12 Irinotecan (CPT-11): A Water-soluble Prodrug of SN-38 -- 5.13 Latanoprost: Isopropylester of a Prostaglandin F2 Analog -- 5.14 Moexipril Hydrochloride: A Prodrug of Moexiprilat -- 5.15 Mycophenolate Mofetil -- 5.16 Olmesartan Medoxomil: A Prodrug of Olmesartan -- 5.17 Omeprazole (Prilosec174;) -- 5.18 Oseltamivir: An Orally Bioavailable Ester Prodrug of Oseltamivir Carboxylate -- 5.19 Parecoxib: A Prodrug of Valdecoxib -- 5.20 Tenofovir Disoproxil Fumarate: An Oral Prodrug of Tenofovir -- 5.21 Travoprost: A Potent PGF2 Analog -- 5.22 Valacyclovir: A Prodrug of Acyclovir -- 5.23 Valganciclovir: A Prodrug of Ganciclovir -- 5.24 Vantin: A Prodrug of Cefpodoxime -- 5.25 Ximelagatran: A Double Prodrug of Melagatran -- Index Summary Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the active compound. The rationale behind administering prodrugs is to optimize absorption, distribution, metabolism, and excretion of these drugs. Since first described in the 1950s, prodrugs continue to be a fertile area of research. There are a number of small pharmaceutical/biotech companies dedicated to using prodrugs for the delivery of older but problematic drugs as well as to developing broad-based prodrug technologies for application to new and future drugs. These volumes represe Analysis farmacologie pharmacology toxicologie toxicology biomedische wetenschappen biomedicine Medicine (General) Geneeskunde (algemeen) Bibliography Includes bibliographical references and index Notes Print version record Subject Prodrugs. Prodrugs Biomédecine. Sciences de la vie. Prodrugs Form Electronic book Author Stella, Valentino J., 1946- ISBN 9780387497853 0387497854 9780387497822 038749782X

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