| Description |
1 online resource (404 pages) : illustrations |
| Series |
Oxidative stress and disease |
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Oxidative stress and disease
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| Contents |
Cover; Half Title Page; Series Page; Title Page; Copyright Page; Contents; Series Preface; Preface; Editors; Contributors; Section I: Development of the Early Programming Concept; Chapter 1: The Developmental Origins of Health and Disease-Where Did It All Begin?; 1.1 The Developmental Origins of Adult Disease-Origins of the Hypothesis; 1.2 The Relationship between Low Birth Weight, Hypertension, and Cardiovascular Disease; 1.3 The Relationship between Low Birth Weight, Obesity, and Type 2 Diabetes; 1.4 The Relationship between Birth Weight and the Metabolic Syndrome |
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1.5 Mechanisms Underlying the Early Origins of Adult Health and Disease1.6 The Developmental Origins of Health and Disease-Future Directions; References; Chapter 2: The Maternal Resources Hypothesis and Childhood Obesity; 2.1 Introduction; 2.2 Bckground; 2.3 Overview of the MRH; 2.4 Mechanisms for Prenatal Maternal Effects; 2.4.1 Role of SM Activation; 2.4.2 Pregnancy and Insulin Resistance; 2.4.3 Progressive Maternal Effects via Reductions in Maternal PA; 2.5 Mechanisms for Postnatal Maternal Effects; 2.6 Nutrient Partitioning and Its Determinants |
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2.7 The Fetal Determinants of Effective Energy (Caloric) Intake2.8 Appetite, Nutrient Partitioning, and Positive Energy Balance; 2.9 Accumulative and "Corrective" Maternal Effects; 2.10 Practical Implications of the MRH; 2.11 Summary of the MRH; References; Chapter 3: Developmental Programming by Environmental Chemicals and Their Influence on Health across the Lifespan; 3.1 Introduction; 3.2 Overview of the DOHaD Epidemiology Literature Focusing on Environmental Chemicals; 3.3 Neurodevelopmental and Neurobehavioral Studies; 3.4 Cancer; 3.5 Obesity and Cardiometabolic Disorders |
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3.6 Epigenetic Regulation3.7 Methodological Challenges; 3.7.1 Exposure Estimation; 3.7.2 Analysis Considerations; 3.8 Summary and Conclusions; References; Section II: Maternal Malnutrition and Fetal Programming; Chapter 4: Protein Deficiency and Pancreatic Development; 4.1 Introduction; 4.2 The Low Protein Diet Model of Maternal Dietary Restriction; 4.3 Metabolic and Pancreatic Phenotype at Birth; 4.4 Ong-term Changes in Pancreatic and Metabolic Function and Plasticity; 4.5 Early Dietary Insult and the Mammalian Target of Rapamycin Axis |
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4.6 Epigenetic Modification of Gene Expression following Exposure to a Low Protein Diet4.7 Prematurity of Cellular Aging; 4.8 Reversal of Pancreatic Dysfunction by Dietary Supplementation with Taurine; 4.9 Reversal of Pancreatic Dysfunction with Statin Treatment; 4.10 Conclusions; Acknowledgments; References; Chapter 5: Placental Insufficiency, Pancreatic Development, and Function; 5.1 Introduction; 5.2 Intrauterine Growth Restriction and Insulin Secretion in Humans; 5.3 Restricted Fetal Growth and Insulin Secretion in Other Animal Species; 5.3.1 Uteroplacental Insufficiency |
| Bibliography |
Includes bibliographical references |
| Notes |
Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force. WlAbNL |
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Print version record |
| Subject |
Pregnancy -- Nutritional aspects.
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Maternal-fetal exchange.
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Fetus -- Development.
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Mothers -- Nutrition.
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Prenatal Exposure Delayed Effects
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Maternal Nutritional Physiological Phenomena
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Maternal-Fetal Exchange -- physiology
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Maternal Exposure -- adverse effects
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Fetal Development
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Prenatal Nutritional Physiological Phenomena
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Maternal-Fetal Exchange
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HEALTH & FITNESS -- Pregnancy & Childbirth.
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MEDICAL -- Gynecology & Obstetrics.
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Mothers -- Nutrition
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Fetus -- Development
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Maternal-fetal exchange
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Pregnancy -- Nutritional aspects
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| Form |
Electronic book
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| ISBN |
1498770657 |
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9781498770651 |
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9781315154312 |
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1315154315 |
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9781351650359 |
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1351650351 |
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