| Description |
1 online resource |
| Series |
Molecular pathology library |
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Molecular pathology library series.
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| Contents |
Intro; Preface; Contents; Contributors; 1: Etiology and  Pathogenesis of  Hepatocellular Carcinoma; 1.1 Introduction; 1.2 Etiology; 1.3 Virus-Induced Hepatocarcinogenesis; 1.3.1 HBV; 1.3.2 HCV; 1.4 NAFLD Cirrhosis-Induced Hepatocarcinogenesis; 1.5 Toxin-Mediated Hepatocarcinogenesis; 1.5.1 Alcohol Induced; 1.5.2 Aflatoxin-B1 Induced; 1.6 Common Themes; 1.7 Molecular Mechanisms; 1.7.1 Methylation; 1.7.2 MET and  HGF; 1.7.3 ErbB Receptor Family; 1.7.4 B-Catenin; 1.7.5 p53 Tumor Suppression; References |
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2: Histologic Classification of  Hepatocellular Carcinoma and  Its Clinical Implications2.1 Conventional Hepatocellular Carcinoma (HCC); 2.2 Small HCC; 2.3 Special Histologic Subtypes; 2.3.1 Fibrolamellar HCC; 2.3.2 Scirrhous HCC; 2.3.3 Steatohepatitic HCC; 2.3.4 Lymphoepithelioma-Like HCC (LEL-HCC); 2.3.5 Sarcomatoid HCC; 2.3.6 Undifferentiated Carcinoma; 2.3.7 Diffuse Cirrhosis-Like HCC (CL-HCC); 2.3.8 Combined Hepatocellular-Cholangiocarcinoma; 2.4 Grading and  Staging; 2.4.1 Grading HCC; 2.4.2 Staging HCC; References |
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3: Molecular Classification of  Hepatocellular Carcinoma and  Precision Medicine3.1 Introduction; 3.2 Molecular Alterations; 3.2.1 TERT; 3.2.2 Wnt/β-Catenin; 3.2.3 p53; 3.2.4 CDKN2A (p16); 3.2.5 AXIN1 and  2; 3.2.6 RAS; 3.2.7 MET; 3.2.8 TGFβ; 3.2.9 VEGFA; 3.2.10 EpCAM; 3.2.11 PTEN; 3.2.12 Epigenetic Alterations; 3.2.13 Chromosome Instability; 3.3 Molecular Classification; 3.3.1 Overview; 3.3.2 Proliferation Class; 3.3.3 Nonproliferation Class; References; 4: Genomics Studies in Hepatocellular Carcinoma via Next-Generation Sequencing |
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4.1 Hepatocellular Carcinoma and  Its Heterogeneity4.1.1 HCC Heterogeneity in Etiology; 4.1.2 HCC Heterogeneity in Clinical Presentation; 4.1.3 HCC Heterogeneity at the  Biological Level; 4.2 Next-Generation Sequencing System; 4.2.1 Roche 454 Sequencing; 4.2.2 Illumina Sequencing; 4.2.3 SOLiD Sequencing; 4.2.4 Ion Personal Genome Machine; 4.2.5 The Third-Generation Sequencers; 4.3 HCC Genomics Studies via NGS Technology; 4.3.1 HCC Viral Risk Factors in Viral-Related HCCs; HBV Integration in HBV-Related HCCs; HCV Quasispecies Diversity in Chronic Liver Disease and  HCC |
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4.3.2 Mutational Landscapes in HCCWNT/Beta-Catenin Pathway and  P53 Pathway; Chromatin Regulators; PI3K/Akt/mTOR-Pathway and  MAPK Pathway; Others; 4.3.3 Expression Profiles of  HCC; 4.3.4 Epigenetic Alterations in HCC; 4.3.5 Potential Clinical Utilization in HCC; 4.4 Conclusion and  Prospective; References; 5: Epigenetic Regulations in the  Pathogenesis of  HCC and  the  Clinical Application; 5.1 Introduction; 5.2 Epigenetics; 5.2.1 DNA Methylation; 5.2.2 Micro RNAs; 5.2.3 Histone Modifications and  Histone Variants; 5.3 Hepatitis B Virus-Associated Hepatocellular Carcinoma |
| Summary |
This volume provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development for hepatocellular carcinoma (HCC). Topics covered include the etiology and pathogenesis of HCC, recent advances in HCC genomics, biomarker discovery and validation in HCC diagnosis, the role of liver biopsy in HCC early diagnosis, and the future prospects of surgical approaches and targeted therapy for HCC. In addition to reviewing the current available knowledge, the book also discusses the future development of a precision and personalized medicine approach for HCC. Written by experts in the field, Precision Molecular Pathology of Liver Cancer is a concise yet comprehensive resource for practitioners who treat patients with hepatocellular carcinoma.#xE003 |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references at the end of each chapters and index |
| Notes |
Online resource; title from PDF title page (Ebsco, viewed January 15, 2018) |
| Subject |
Liver -- Cancer -- Molecular aspects
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Liver -- Cancer -- Diagnosis
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Carcinoma, Hepatocellular -- pathology
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Carcinoma, Hepatocellular -- therapy
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Pathology, Molecular -- methods
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Precision Medicine -- methods
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Gastroenterology.
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Oncology.
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Pathology.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Liver -- Cancer -- Diagnosis
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| Form |
Electronic book
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| Author |
Liu, Chen, editor
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| ISBN |
9783319680828 |
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331968082X |
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