| Description |
1 online resource : illustrations |
| Series |
Biomaterials science series, 2397-141X ; no. 2 |
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Biomaterials science series ; no. 2.
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| Contents |
Cover; Preface; Contents; Chapter 1 Thermogelling Polymers and Their History; 1.1 Introduction; 1.2 Synthesis; 1.3 Micellization and Thermogelling Properties; 1.3.1 Gelation Mechanism; 1.3.2 Kinetics of Micellization; 1.3.3 Formation of Micelles with Different Morphologies; 1.4 Pluronic Systems in the Biomedical Sciences; 1.4.1 Early Uses; 1.4.2 Wound Healing; 1.4.3 Drug Delivery; 1.5 Disadvantages of Pluronic Systems; 1.6 Modifications of Pluronic Copolymers; 1.6.1 Modified Pluronic Copolymers for Improved Mechanical Properties |
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1.6.2 Modified Pluronic Copolymers for Improved Biodegradability1.7 Modern Applications of Pluronics; 1.8 Future Perspectives; References; Chapter 2 Thermogelling PLGA-based Copolymers; 2.1 History and Structures; 2.2 Synthesis; 2.3 Properties; 2.3.1 Reversible Sol-to-gel Transition; 2.3.2 Degradation; 2.3.3 Biocompatibility; 2.4 Applications; 2.4.1 Drug Release; 2.4.2 Gene Delivery; 2.4.3 Postoperative Adhesion Prevention; 2.5 Areas for Future Research; 2.6 Conclusions; References |
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Chapter 3 Polyester-based Biodegradable Thermogelling Systems as Emerging Materials for Therapeutic Applications3.1 Introduction; 3.2 Polyester-based Thermogelling Systems; 3.2.1 The Poly(lactic acid)-based Thermogelling Systems; 3.2.2 Polycaprolactone-based Thermogelling Systems; 3.2.3 Poly([R]-3-hydroxybutyrate)-based Thermogelling System; 3.2.4 Poly(glycerol sebacate)-based Thermogelling Systems; 3.3 Application of Polyester-based Thermogelling Systems; 3.3.1 Therapeutic Delivery; 3.3.2 Tissue Engineering; 3.4 Conclusion; Abbreviations; References |
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Chapter 4 Biodegradable Thermogelling Polymers for Drug Delivery4.1 Introduction; 4.2 Thermogelling Mechanism; 4.3 Mechanism of Drug Release in Thermogels; 4.4 Advantages and Disadvantages of Thermogelling Polymeric Materials Compared to Other Drug-delivery Methods; 4.5 Delivery of Insulin and Protein Drugs in the Treatment of Diabetes; 4.6 Adaptation of Thermogels for Biomedical Applications; 4.6.1 Selenium-containing Thermogels; 4.6.2 Matrix Metalloproteinase-sensitive Thermogelling Polymers; 4.7 Towards Understanding In-vivo Effectiveness of Polymeric Thermogel Drug Delivery |
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4.7.1 Toxicological Aspects of the Use of Dextran Microspheres and Thermogelling Ethyl(hydroxyethyl) Cellulose as Nasal Drug-delivery Systems4.7.2 In-vivo Pharmacological Evaluations of an Antioxidant-loaded Biodegradable Thermogel; 4.8 Conclusion; References; Chapter 5 Injectable Thermogelling Polymers for Bone and Cartilage Tissue Engineering; 5.1 Introduction; 5.2 Scaffold Requirements for Bone and Cartilage Tissue Engineering; 5.3 Chemistry and Properties of Selected Injectable Thermogelling Scaffolds; 5.3.1 Totally Non-degradable Polymers; 5.3.2 Enzymatically Degradable Polymers |
| Summary |
Biodegradable thermogels are a promising class of stimuli-responsive polymers. This book summarizes recent developments in thermogel research with a focus on synthesis and self-assembly mechanisms, gel biodegradability, and applications for drug delivery, cell encapsulation and tissue engineering |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from digital title page (viewed on November 14, 2018) |
| Subject |
Polymers in medicine.
|
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Polymers -- Biotechnology
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SCIENCE -- Chemistry -- Organic.
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Polymers in medicine
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Polymers -- Biotechnology
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| Form |
Electronic book
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| Author |
Loh, Xian Jun, editor
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|
Young, David James, editor
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| ISBN |
9781788012676 |
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1788012674 |
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9781523122967 |
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152312296X |
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