| Description |
1 online resource : text file, PDF |
| Series |
Frontiers in Neuroscience |
| Contents |
Cover; Half Title; Series Page; Title page; Copyright Page; Dedication Page; Table of Contents; Preface; Editor; List of Contributors; Chapter 1: TRP Channels ; 1.1 Introduction; 1.2 TRPA; 1.3 TRPC; 1.4 TRPM; 1.5 TRPML; 1.6 TRPN; 1.7 TRPP; 1.8 TRPV; 1.9 Conclusion; References; Chapter 2: Molecular Mechanisms of Temperature Gating in TRP Channels; 2.1 Introduction; 2.2 Structural Prelude; 2.3 Ligand and Voltage Gating in ThermoTRP Channels; 2.4 Mechanism of Gating by Temperature; 2.5 Physical Theories of Activation by Temperature; 2.5.1 Role of Pore Region; 2.5.2 Role of Transmembrane Domains |
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2.5.3 Role of Intracellular RegionsAcknowledgments; References; Chapter 3: TRP Channels in Vision; 3.1 Introduction; 3.2 Drosophila Phototransduction; 3.2.1 Coupling of Photoexcited Rhodopsin to Inositol Phospholipid Hydrolysis; 3.2.2 Rhodopsin and the Photochemical Cycle; 3.2.3 Photoreceptor Potential and Prolonged Depolarizing Afterpotential: A Tool for Discovery of Phototransduction Components; 3.2.4 Light-Activated G Protein; 3.2.5 Role of PLC in Light Excitation and Adaptation; 3.2.6 Phosphoinositide (PI) Cycle; 3.2.7 Single-Photon Responses and Spontaneous Dark Bumps |
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3.2.7.1 Spontaneous Dark Bumps3.2.8 Single-Photon Responses: Quantum Bumps; 3.3 Evolution of TRPC Channels in Photoreceptor Cells; 3.3.1 Complex Phylogeny of TRPC Channels in Invertebrate Species; 3.3.2 TRPC Channels from Two Major Clades Shown to Be Expressed in Microvillar Photoreceptors; 3.3.3 A Variety of Putative Pore Selectivity Filter Sequences Have Evolved; 3.4 Properties and Organization of TRP Channels; 3.4.1 General Structural Features of TRP Channels; 3.4.2 Structural Features of Drosophila TRP and TRPL Channels |
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3.4.3 Organization in Supramolecular Signaling Complex via Scaffold Protein INAD3.4.4 Assembly of TRP Channels; 3.4.5 Biophysical Properties of TRP Channels; 3.4.6 Stimulus-Dependent TRP Channel Translocation; 3.4.7 TRP Channel Regulation by Phosphorylation; 3.5 Gating Mechanism of Drosophila TRP Channels; 3.5.1 Lipids Activate Light-Sensitive Channels in the Dark; 3.5.2 PUFA as Second Messenger of Excitation; 3.5.3 Is Drosophila TRP a Mechanosensitive Channel?; 3.6 Concluding Remarks; Acknowledgments; References; Chapter 4: Sensory Mechanotransduction and Thermotransduction in Invertebrates |
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4.1 Structure and Function of TRP Channels in Invertebrates4.2 Mechanosensation and Thermosensation in Adult Caenorhabditis Elegans; 4.2.1 Response to Gentle (and Harsh Touch) in C. Elegans Adults, TRPN; 4.2.2 Response to Harsh Touch in C. Elegans Adults, TRPV and TRPA; 4.2.3 Response to Harsh Touch and Low Temperatures in C. Elegans Adults, TRPV and TRPA; 4.2.4 Response to Harsh Touch and High Temperatures in C. Elegans Adults, TRPV; 4.3 Mechanosensation in Adult and Larval Drosophila Flies; 4.3.1 Mechanosensory Neurons in Drosophila Adult Flies, TRPN and TRPV |
| Summary |
"During the last two decades, there has been an explosion of research pertaining to the molecular mechanisms that allow for organisms to detect different stimuli that is an essential feature for their survival. Among these mechanisms, living beings need to be able to respond to different temperatures as well as chemical and physical stimuli. Thermally activated ion channels were proposed to be present in sensory neurons in the 1980s, but it was not until 1997 that a heat- and capsaicin- activated ion channel, TRPV1, was cloned and its function described in detail. This groundbreaking discovery led to the identification and characterization of several more proteins of the family of Transient Receptor Potential (TRP) ion channels. Intensive research has provided us with the atomic structures of some of these proteins, as well as understanding of their physiological roles, both in normal and pathological conditions. With chapters contributed by renowned experts in the field, Neurobiology of TRP Channels contains a state- of- the- art overview of our knowledge of TRP channels, ranging from structure to their functions in organismal physiology.? Features:" Contains chapters on the roles of several TRP ion channels with a diversity of physiological functions, providing a complete picture of the widespread importance of these proteins." Presents an overview of the structure of TRP channels, including the roles of these proteins in different physiological processes." Discusses the roles of TRP channels in pathophysiological processes, further highlighting their importance." Features several full color illustrations to allow the reader better comprehension of TRP channels. A volume in the Frontiers in Neuroscience series"--Provided by publisher |
| Bibliography |
Includes bibliographical references |
| Subject |
TRP channels.
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Membrane proteins.
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Ion channels.
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Neurobiology.
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Biochemistry.
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biochemistry.
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SCIENCE -- Life Sciences -- Biology -- Molecular Biology.
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SCIENCE -- Life Sciences -- Neuroscience.
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SCIENCE -- Life Sciences -- Biochemistry.
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Biochemistry
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Ion channels
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Membrane proteins
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Neurobiology
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TRP channels
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| Form |
Electronic book
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| ISBN |
9781315152837 |
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1315152835 |
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9781351648868 |
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1351648861 |
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9781498755269 |
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1498755267 |
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