| Description |
1 online resource (xiv, 734 pages) : illustrations (some color) |
| Contents |
Peroxisome biogenesis -- Metabolic role of mammalian peroxisomes -- Peroxisomal disorders -- Molecular mechanism of peroxisome proliferator action -- Peroxisome proliferators as cytochrome P450 inducers -- Peroxisome proliferation: lipid metabolism and receptors -- Molecular mechanisms involved in induction of peroxisomal [beta]-oxidation enzymes by hypolipidaemic agents -- Molecular basis of gene regulation by peroxisome proliferators -- Molecular evolution of the urate oxidase encoding gene and its functional significance -- Possible role of CoASH esters on xenobiotic-induced peroxisomal proliferation and non-genotoxic carcinogenesis -- Modulation of peroxisomal biogenesis and lipid metabolising enzymes by dietary factors |
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(cont) Proliferation of peroxisomes and mitochondria and modulation of lipid metabolizing enzymes by hypolipidaemic, non-[beta]-oxidizable fatty acids (3-thia fatty acids) -- Cultured hepatocytes: a useful in vitro system to investigate effects induced by peroxisome proliferators and their species specificity -- Structure-activity relationships for chemically induced peroxisome proliferation in mammalian liver -- Tetrazole substituted acetophenone peroxisome proliferators: structure-activity relationships and effects on hepatic lipid metabolism -- Structural requirements for peroxisome proliferation by phenoxyacetic and fatty acid analogues in primary cultures of rat hepatocytes -- Ultrastructural and biochemical aspects of peroxisome proliferation and biogenesis in different mammalian species -- Toxicological studies in primates with three fibrates |
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Structure-, enantiomer- and species-specific effects of fibrate analogues on peroxisome proliferation and increased activity of mitochondrial [alpha]-glycerophosphate dehydrogenase -- Metabolism of di-(2-ethylhexyl)phthalate (DEHP) and di-(2-ethylhexyl)adipate (DEHA) and their relationship to peroxisome proliferation in different species -- Extrahepatic peroxisome proliferation and the extrahepatic effects of peroxisome proliferators -- Biological aspects of peroxisome proliferator-induced liver tumours in the rat -- Genotoxicity studies of peroxisome proliferators -- Production of 8-hydroxydeoxyguanosine in rodent liver by the administration of peroxisome proliferators -- Role of oxidative stress and enhanced cell replication in the hepatocarcinogenicity of peroxisome proliferators -- Hyperplastic responses to peroxisome proliferators |
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(cont) Hepatic changes associated with peroxisome proliferation -- Peroxisome proliferators as initiators and promoters of rodent hepatocarcinogensis -- Are peroxisome proliferators tumour promoters in rat liver? -- Risk assessment of chemicals inducing peroxisome proliferation |
| Summary |
There is currently interest in the effect of peroxisome proliferation, and in proliferators and their modes of action. Peroxisomes (or "microbodies") are single membrane-limited cytoplasmic organelles present in the cells of animals, plants, fungi and protozoa.; This book describes the basic structure and functions of these organelles which are responsible for many cellular functions including an active auxilliary fatty acid B-oxidation system. During treatment with severally clinically used drugs and environmental contaminants, the synthesis of peroxisomes is greatly increased, this proliferation having a number of toxicological consequences particularly in relation to liver cancer |
| Analysis |
Mammals Cells Biochemistry |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Peroxisomes.
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Microbodies
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42.15 cytology, cell biology and cell physiology.
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SCIENCE -- Life Sciences -- Cell Biology.
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Peroxisomes
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Peroxysomen.
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| Form |
Electronic book
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| Author |
Gibson, G. Gordon
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Lake, Brian, 1948-
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| ISBN |
0203481518 |
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9780203481516 |
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1280405430 |
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9781280405433 |
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