| Description |
1 online resource (xvii, 460 pages) : illustrations (some color) |
| Contents |
Front Cover -- BASIC AND APPLIED BONE BIOLOGY -- BASIC AND APPLIED BONE BIOLOGY -- Copyright -- Dedication -- Contents -- List of Contributors -- Biographies -- Preface (First Edition) -- Preface (Second Edition) -- I -- BASIC BONE BIOLOGY AND PHYSIOLOGY -- 1 -- Bone Morphology and Organization -- THE FUNCTIONS OF BONE -- BONE IS ORGANIZED AS A MULTISCALE MATERIAL -- BONE COMPOSITION -- THE NANOSCALE ORGANIZATION OF BONE -- Collagen -- Enzymatically Mediated Collagen Cross-Linking -- Nonenzymatically Mediated Collagen Cross-Linking -- Collagen Orientation -- Bone Mineral |
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Noncollagenous Extracellular Matrix Proteins -- Proteoglycans and Glycosaminoglycans -- Glycoproteins -- SIBLING Proteins -- Osteocalcin -- Osteonectin -- THE MICROSTRUCTURAL ORGANIZATION OF BONE -- Woven Bone -- Primary Bone -- Primary Lamellar Bone -- Plexiform Bone -- Primary Osteons -- Secondary Bone -- Interstitial Bone -- THE MACROSCOPIC ORGANIZATION OF BONE -- Cortical Bone -- Skeletal Envelopes -- THE BLOOD SUPPLY AND INNERVATION OF BONE -- Blood Supply -- Innervation of Bone -- BONE FLUID COMPARTMENTS -- BONE MASS AND BONE QUALITY -- Rate of Bone Turnover -- Bone Trabecular Architecture |
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Tissue Material (Intrinsic) Properties -- Microdamage Accumulation -- Suggested Readings -- 2 -- Bone Marrow and the Stem Cell Niche -- NICHES IN DEVELOPMENT -- IMAGING OF NICHES -- BONE MARROW NICHE CELLS -- Nonhematopoietic -- Osteoblastic Cells -- Mesenchymal Stromal/Stem Cell Populations -- Adipocytes -- Endothelial Cells -- Hematopoietic -- Megakaryocytes -- Macrophages -- Neutrophils -- Osteoclasts -- NEURONAL REGULATION OF THE HEMATOPOIETIC STEM CELL NICHE -- HORMONAL REGULATION OF THE HEMATOPOIETIC STEM CELL NICHE -- NICHES AND MALIGNANCIES -- AGING AND THE BONE MARROW MICROENVIRONMENT |
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THE FUTURE -- Suggested Readings -- 3 -- Bone Cells -- OSTEOCLASTS -- Osteoclast Morphology and Function -- Osteoclast Differentiation and Fusion -- Osteoclast Apoptosis -- Regulation of Osteoclast Generation and Survival -- OSTEOBLASTS -- Osteoblast Morphology and Function -- Osteoblast Formation and Differentiation -- Osteoblast Apoptosis -- Regulation of Osteoblast Generation and Survival -- Bone Lining Cells -- OSTEOCYTES -- Osteocyte Morphology and Functions -- Osteocytogenesis and Osteocyte Maturation -- Osteocyte Apoptosis: Consequences and Regulation |
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Preservation of Osteocyte Viability by Mechanical Stimuli -- Aging and Osteocyte Apoptosis -- Hormonal Regulation of Osteocyte Life Span -- Regulation of Bone Formation by Osteocytes: The Sclerostin Paradigm -- Regulation of Bone Resorption by Osteocytes: RANKL and OPG -- Regulation of Bone Mineralization by Osteocytes -- Suggested Readings -- 4 -- Local Regulation of Bone Cell Function -- OVERVIEW OF CYTOKINES AND GROWTH FACTORS AND THEIR RECEPTORS -- Definition: Cytokines Versus Growth Factors -- Soluble Ligands -- Membrane-Bound Ligands -- Receptor Classification -- Signal Transduction Cascades |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (ScienceDirect, viewed February 27, 2019) |
| Subject |
Bones.
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Baby bonnets.
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Bone and Bones
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bonnets (hats)
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bone (material)
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Bones
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| Form |
Electronic book
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| Author |
Burr, David B., editor.
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Allen, Matthew R. (Professor of anatomy and cell biology), editor.
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| ISBN |
9780128132609 |
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0128132604 |
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