Title Handbook on mass spectrometry : instrumentation, data and analysis, and applications / J.K. Lang, editor

Published New York : Nova Science Publishers, [2009] ©2009

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Description 1 online resource (xviii, 525 pages) : illustrations Series Advances in chemistry research series Advances in chemistry research series Contents ""HANDBOOK ON MASS SPECTROMETRY:INSTRUMENTATION, DATAAND ANALYSIS, AND APPLICATIONS""; ""CONTENTS""; ""PREFACE""; ""MASS SPECTROMETRIC CHARACTERIZATIONOF ORGANOMETALLIC COMPOUNDS""; ""ABSTRACT""; ""1. INTRODUCTION""; ""2. IONIZATION TECHNIQUES""; ""3. MASS ANALYZERS""; ""4. BASIC IONIZATION MECHANISMS OF ORGANOMETALLICS""; ""5. MASS SPECTROMETRY OF INDIVIDUAL ORGANOMETALLICCLASSES""; ""5.1. Main Group Organometallic Compounds""; ""Simple main group organometallic compounds""; ""Organotin compounds""; ""Organolead compounds""; ""Organogermanium compounds"" ""1.1. Characteristics of Global Analyses and Diagnostic Availability ofBiomarkers""""1.2. Advantages of Proteomic Analysis in the Search for DiagnosticBiomarkers""; ""1.3. Specimen""; ""2. SEPARATION TECHNOLOGIES IN PROTEOMIC ANALYSIS""; ""2.1. 2D-DIGE""; ""2.2. ProteinChip Array®""; ""2.3. ClinProt®""; ""2.4. Shotgun Proteomics Using LC""; ""3. MASS SPECTROMETRY""; ""3.1. Fundamentals of MS""; ""3.2. Ionization Methods""; ""3.3. Mass Analyzers""; ""3.4. Types of MS Used in Proteomic Analysis""; ""4. IDENTIFICATION OF PROTEINS/PEPTIDES USING MS"" ""2.6.1.2. Feature/peak detection""""2.6.1.3. Alignment""; ""2.6.1.4. Normalisation""; ""2.6.2. Data analysis""; ""2.6.2.1. Principal component analysis (PCA) ""; ""2.6.2.2 Partial least-squares projections to latens structures (PLS)""; ""2.6.2.3. O-PLS""; ""2.7. Metabolite Identification""; ""3. CONCLUSION""; ""REFERENCES""; ""BIOMARKER DISCOVERY FOR CANCERDIAGNOSIS USING SERUM PROTEOMIC ANALYSIS:FROM BASIC RESEARCH TO CLINICAL APPLICATION""; ""ABSTRACT""; ""INTRODUCTION""; ""1. PROTEOMIC ANALYSIS OF SERUM/PLASMA IS EFFECTIVETO SEARCH FOR CANCER DIAGNOSTIC MARKERS"" ""ABSTRACT""""1. METABOLOMICS?""; ""1.1. The Positioning of Metabolomics in Research""; ""1.2. Challenges in Metabolomics Approaches""; ""1.3. Mass Spectrometry in Metabolomics Research""; ""2. STAGES IN AN LC-MS BASED METABOLOMICS ANALYSIS""; ""2.1. Sample Collection and Sample Storage""; ""2.2. Sample Homogenisation/Extraction/Deproteinisation""; ""2.3. Liquid Chromatography (LC)""; ""2.4. The Ionisation Process as an Interface between LC and MS: Focus onMatrix Effect""; ""2.5. Mass Spectrometry""; ""2.6. Data Handling""; ""2.6.1. Data processing""; ""2.6.1.1. Filtering"" ""Organoarsenic, organoantimony and organobismuth compounds""""Organoboron compounds""; ""Organoaluminum, organogallium and organoindium compounds""; ""Organoselenium and organotellurium compounds""; ""Organosilicon compounds""; ""5.2. Transition Metal Organometallic Compounds""; ""Metallocenes and related compounds""; ""Transition metal organometallic compounds containing covalent carbon-metal bond""; ""Heteropolymetallic complexes""; ""5.3. Organometallics Compounds Containing Lanthanoids""; ""6. CONCLUSION""; ""ACKNOWLEDGMENTS""; ""7. REFERENCES""; ""LC-MS BASED METABOLOMICS"" Bibliography Includes bibliographical references and index Notes Print version record Subject Chemistry, Analytic. Mass spectrometry. Form Electronic book Author Lang, J. K. LC no. 2009029337 ISBN 1612096921 (electronic bk.) 9781612096926 (electronic bk.)

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