| Description |
1 online resource (139 pages) |
| Contents |
1.4.3.3 PCR-Single Stranded Conformation Polymorphism (PCR-SSCP) -- 1.4.3.4 PCR-Restriction Fragment Length Polymorphism (PCR-RFLP) -- 1.4.3.5 PCR-Amplification Created Restriction Digestion Polymorphism (PCR-ACRS) -- 1.4.3.6 Allele Specific-Polymerase Chain Reaction (AS-PCR) -- References -- Chapter 2: A1/A2 Milk Hypothesis -- 2.1 Foundation of A1/A2 Milk Hypothesis -- 2.2 Genetics of A1/A2 Milk Hypothesis -- 2.3 Scientific Evidence Behind A1 Milk Hypothesis -- 2.3.1 Ecological Correlations -- 2.3.2 Animal Trials -- 2.3.3 Case Control Studies |
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5.3.1 Ecological Studies -- 5.3.2 Animal Studies -- 5.3.3 Case Controls -- 5.3.4 Sibling Studies -- 5.4 Critique of the A1 Milk Hypothesis and T1D -- 5.5 European Food Safety Authority (EFSA) Report -- 5.6 Possible Mechanism -- 5.7 Present Status of A1 Milk Hypothesis -- 5.8 Conclusions -- 5.9 Future Perspectives of A1 Milk Hypothesis -- References -- Chapter 6: A1 Milk and Heart Diseases -- 6.1 Cow Milk Peptides and Cardiovascular Health -- 6.2 A1 Milk and Heart Diseases -- 6.3 LDL Oxidation -- 6.4 Evidences in Favour of A1 Milk Hypothesis and Heart Diseases -- 6.4.1 Animal Trials |
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2.3.4 Biochemsitry (?-Casomorphin Release from A1 ?-Casein) -- 2.3.5 Pharmacology (Opioid Nature of BCM Peptides) -- 2.3.6 Subjective Experiences -- 2.3.7 Milk Intolerances -- 2.3.8 Mild Allergies -- 2.4 Commercialization of A2 Milk -- References -- Chapter 3: ?-Casomorphin I -- 3.1 Structure of Bovine ?-Casomorphins -- 3.2 Classification of Bovine ?-Casomorphins -- 3.3 Production of ?-Casomorphins -- 3.3.1 Cow Milk (Whole) -- 3.3.2 Fermented Milk -- 3.3.3 Cheese -- 3.3.4 Infant Formulas -- 3.4 BCM Release During SGID -- 3.5 Processing of Cow Milk and BCM Release -- References |
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Chapter 4: ?-Casomorphin II -- 4.1 ?-Casomorphins and Gastrointestinal Regulation -- 4.2 Respiratory Effects -- 4.3 Analgesic Effects -- 4.4 Tolerance and Dependence -- 4.5 Cardiovascular Effects -- 4.6 Immunological Perspective of BCMs -- 4.6.1 Production of Mucins and Innate Immunity -- 4.6.2 Proliferation of Lymphocytes and Cellular Immunity -- 4.6.3 Milk Allergy -- 4.6.4 Milk Intolerances -- References -- Chapter 5: A1 Milk and Type 1 Diabetes (T1D) -- 5.1 A1 Milk and Health Concerns -- 5.2 A1 Milk and Type 1 Diabetes Mellitus (T1D) -- 5.3 Evidences in Favour of A1/A2 Milk Hypothesis |
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Intro -- Preface -- Acknowledgments -- About the Book -- Contents -- About the Author -- Abbreviations -- Chapter 1: Cow Milk -- 1.1 Introduction to Cow Milk -- 1.1.1 Milk Production -- 1.1.2 Milk Processing -- 1.1.3 Milk Products -- 1.2 Cow Milk Proteins -- 1.3 Cow Milk Caseins -- 1.4 ?-Casein Variants -- 1.4.1 Worldwide Distribution of A1/A2 ?-Casein Allele Frequency in Cows -- 1.4.2 Distribution of A1/A2 ?-Casein Alleles in Indian Cows -- 1.4.3 Methods of Screening ?-Casein (A1/A2) Variants -- 1.4.3.1 Paper Electrophoresis -- 1.4.3.2 Acid-Urea Polyacrylamide Gel Electrophoresis |
| Summary |
This book compiles the latest research on the A1 and A2 forms of cow milk, and attempts to show a correlation between the type of cow milk consumption and reported incidence of certain diseases (type 1 diabetes mellitus, cardiovascular diseases, sudden infant death syndrome and neurological disorders). Cow milk generally contains two types of [beta]-casein, A1 or A2. The book describes the A1/A2 hypothesis, its foundation and the genetics behind it. It discusses the two forms of milk and why one is considered more harmful than the other. Seeking to provide a balanced view of the milk types, the book's initial chapters highlight the structure, function and physiological activity of [beta]-casomorphins. Subsequent sections describe the health concerns associated with A1 milk, and the various case studies and research surrounding it. In turn, the arguments against the hypothesis put forward by EFSA, American Nutritionists and Truswell are also highlighted. The book does not make any recommendations for dairy consumers; rather, it is a collection of essential data both in favour and against the hypothesis. Further mechanistic studies involving well-designed animal and human trials at the cellular, molecular, biochemical and immunological levels will be needed in order to draw sound conclusions. Overall, the hypothesis is fascinating, and possibly significant. However, verified and authenticated research with reproducible results is needed to make final consumer recommendations. This timely book offers a valuable resource for researchers and students of dairy science, as well as industry experts |
| Notes |
Print version record |
| Subject |
Casein.
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Casein -- Health aspects
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Milk.
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Milk proteins.
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Caseins
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Milk
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Milk Proteins
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Peptide Fragments
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Immune System -- physiology
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milk.
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Milk proteins
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Milk
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Casein
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| Form |
Electronic book
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| ISBN |
9789811534577 |
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9811534578 |
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