| Description |
1 online resource (0 p.) |
| Series |
Neurobiology of Addiction Ser. ; v.Volume 3 |
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Neurobiology of Addiction Ser
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| Contents |
Front Cover -- ALCOHOL -- Alcohol -- Volume 3 of Neurobiology of Addiction series: -- ALCOHOL -- Copyright -- Dedication -- CONTENTS -- Preface -- References -- Acknowledgments -- List of abbreviations -- Volume Three. Alcohol -- 1. Definitions -- 2. History of alcohol use, misuse, and addiction -- 3. Behavioral effects of alcohol -- 4. Pharmacokinetics -- 5. Misuse and addiction potential -- 5.1 Alcohol use disorder -- 5.2 Alcohol withdrawal -- 5.3 Alcohol tolerance -- 5.4 Alcohol toxicity -- 5.4.1 Epidemiology -- 5.4.2 Sexual dysfunction -- 5.4.3 Liver, heart, and cancer toxicity |
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5.4.4 Neurological disorders -- 5.5 Fetal alcohol spectrum disorder -- 6. Behavioral mechanism of action -- 7. Neurobiological effects -- 7.1 Binge/intoxication stage: acute reinforcing and anxiolytic effects -- 7.1.1 Neurobiological effects of low-dose alcohol on the brain -- 7.1.2 Neurobiological mechanism: neurocircuitry of acute reinforcing effects -- 7.1.2.1 GABA -- 7.1.2.2 Opioid peptides -- 7.1.2.3 Endocannabinoids -- 7.1.2.4 Dopamine -- 7.1.2.5 Acetylcholine -- 7.1.2.6 Serotonin -- 7.1.2.7 Norepinephrine -- 7.1.2.8 Glycine -- 7.1.2.9 Acetaldehyde and acetate |
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7.1.2.10 Other neuromodulatory systems -- 7.1.2.11 Neuroinflammatory signaling -- 7.1.2.12 Brain extracellular matrix -- 7.1.3 Neurobiological mechanism: neurocircuitry of incentive salience -- 7.1.4 Neurobiological mechanism: neurocircuitry of pathological habits -- 7.1.5 Neurocircuitry of binge/intoxication stage: brain imaging -- 7.1.6 Neurodevelopmental vulnerability: binge/intoxication stage -- 7.1.7 Neurobiology of sleep in the binge/intoxication stage -- 7.1.8 Neurobiological mechanism: cellular -- 7.1.8.1 Cellular mechanisms in the ventral tegmental area |
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7.1.8.2 Cellular mechanisms in the basal ganglia -- 7.1.8.3 Cellular mechanisms in the extended amygdala -- 7.1.8.4 Pathological habits: nucleus accumbens, dorsomedial striatum, and dorsolateral striatum -- 7.1.8.5 Neurogenesis -- 7.1.9 Neurobiological mechanism: molecular -- 7.1.9.1 Alcohol allosteric modulation of receptors -- 7.1.9.1.1 Ligand-gated ionotropic receptors -- 7.1.9.1.2 Ethanol-receptive elements: molecular structural studies -- 7.1.9.1.3 Second-messenger systems -- 7.1.9.2 Molecular genetic approaches using quantitative trait loci analysis |
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7.1.9.3 Candidate genes: binge/intoxication -- 7.1.10 Sex differences: binge/intoxication stage -- 7.1.11 Summary: binge/intoxication stage -- 7.2 Withdrawal/negative affect stage: tolerance, withdrawal, and dependence -- 7.2.1 Neurobiological mechanism: neurocircuitry -- 7.2.1.1 Theoretical framework -- 7.2.1.2 Hyperkatifeia versus physical withdrawal -- 7.2.1.3 Tolerance -- 7.2.1.3.1 Early studies -- 7.2.1.3.2 Within/between-system neuroadaptations -- 7.2.1.3.2.1 Within-system neuroadaptations -- 7.2.1.3.2.2 Between-system neuroadaptations -- 7.2.1.3.2.3 Low sensitivity in humans |
| Notes |
Description based upon print version of record |
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7.2.1.4 Alcohol withdrawal and dependence |
| Form |
Electronic book
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| Author |
Arends, Michael A
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McCracken, Mandy
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Le Moal, Michel
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| ISBN |
9780128167946 |
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0128167947 |
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