| Description |
1 online resource (vii, 128 pages .) |
| Series |
Pediatric and adolescent medicine, 1017-5989 ; vol. 18 |
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Pediatric and adolescent medicine ; v. 18. 1017-5989
|
| Contents |
Influence of maturation and growth on drug metabolism from fetal to neonatal to adult life / Lindemalm, S.; van den Anker, J.N. -- How to translate pharmacokinetic data into dosing recommendations / Krekels, E.H.J.; Knibbe, C.A.J.; Pokorna, P.; Tibboel, D. -- Pharmacovigilance in neonatal intensive care / Turner, M.A.; Hill, H. -- Neonatal formulations and additives / Allegaert, K.; Turner, M.A.; van den Anker, J.N. -- Modelling and simulation to support neonatal clinical trials / Khalil, F.M.N.; Loër, S. -- A systematic review of paracetamol and closure of patent ductus arteriosus : are we ready for prime time? / Hammerman, C.; Mimouni, F.B.; Bin-Nun, A. -- Formulation of preterm formula : what's in it, and why? / Mimouni, F.B. Aviv; Mandel, D.; Lubetzky, R. -- Neonatal pharmacotherapy : legal and regulatory issues / Bax, R.; Tomasi, P |
| Summary |
In order to provide safe and effective drug therapy to neonates, it is necessary to know about and understand the impact their development has on the pharmacokinetics and pharmacodynamics of drugs. The fact that children are different and neonates very different from adults means that, in neonates, it would be unwise to dose medications by scaling down adult doses proportionately, simply attempting to match their smaller weight and/or body surface area. When one makes decisions about neonatal drug therapy, one must not only take into consideration the available data but also critically assess and interpret this information within the context of fetal development and maturational processes as well as within the context of diseases that might affect a drug's biodisposition. This book includes the latest information on the regulation and scientific basis of drug development and also provides a rationale for formula development for preterm infants. It offers guidance on how to translate pharmacokinetic data into dosing recommendations and also covers legal and regulatory issues relating to neonatal pharmacotherapy |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
Print version record |
| Subject |
Newborn infants -- Effect of drugs on.
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Newborn infants -- Nutrition.
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Infant formulas.
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Drugs -- Dosage.
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Infant, Newborn -- metabolism
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Pharmacological Phenomena
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Infant Formula
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Infant, Newborn, Diseases -- drug therapy
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Pharmaceutical Preparations -- administration & dosage
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MEDICAL -- Gynecology & Obstetrics.
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Infant formulas
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Drugs -- Dosage
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Newborn infants -- Effect of drugs on
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Newborn infants -- Nutrition
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| Form |
Electronic book
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| Author |
Mimouni, Francis, editor.
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Van den Anker, John N., editor.
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| ISBN |
9783318027365 |
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3318027367 |
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9781322454023 |
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1322454027 |
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