| Description |
1 online resource (xxxi, 1526 pages) : illustrations (chiefly color) |
| Contents |
Intro -- Foreword -- Contents -- About the Editor -- Section Editors -- Contributors -- Part I: Cell-Based Therapy Approach: Mesenchymal Stem Cell-Based Therapy -- 1 Human Mesenchymal Stem Cells: The Art to Use Them in the Treatment of Previously Untreatable -- Introduction -- Mesenchymal Stem Cells Current Status: The ̀̀Problems ́́That in Reality Do Not Exist -- Practical Approaches: The Golden Standards, i.e., ̀̀Good Biological Praxis ́́(GBP) Using the Historical Laboratory Experience -- Data Extrapolation from Small Animal Studies to Humans Is Unfounded and Without Relevance |
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Current Research Paradigm: MSCs in Advanced Phases of Clinical Trials Although Understandable Is Far from Personalized Medicine -- A Case of Autologous Versus Allogeneic MSCs, an Unanswered Question -- A Case for Autologous Cells -- Autologous Cells from Patients Are Also ̀̀sick ́́ -- Autologous Cells in Elderly Patients Are Also Aged -- A Case for Allogeneic Cells -- Logistic Advantage of Allogenic MSCs -- Allogenic MSCs Overcome the Limitations of Aging and Sickness of Autologous Cells -- Quality Control of MSCs Preparation: A Prerequisite for Optimal Prognosis -- Conclusion -- References |
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2 Sources and Therapeutic Strategies of Mesenchymal Stem Cells in Regenerative Medicine -- Introduction -- Mesenchymal Stem Cells -- Sources of Mesenchymal Stem Cells -- Bone Marrow-Derived MSCs -- Advantages of BM-Derived MSCs -- Limitations of BM-Derived MSCs -- Adipose Tissue-Derived MSCs -- Advantages of Adipose Tissue-Derived MSCs -- Limitations of Adipose Tissue-Derived MSCs -- Isolation of Adipose Tissue-Derived MSCs -- Clinical Applications of Adipose Tissue-Derived MSCs -- Umbilical Cord-Derived MSCs -- Human Umbilical Cord Structure and Function -- Advantages of WJ-Derived MSCs |
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Limitations of WJ-Derived MSCs -- Isolation Methods of WJ-Derived MSCs -- Clinical Applications of WJ-Derived MSCs -- Therapeutic Strategies of Using MSCs -- Tissue Regeneration -- Immunomodulation of MSCs -- Extracellular Vesicles/Exosomes Derived from MSCs -- MSCs Act as an Efficient Tool for Gene Therapy -- References -- 3 Considerations for Clinical Use of Mesenchymal Stromal Cells -- Introduction -- Biological Characteristics -- Phenotypic Profile -- MSCs ́Proliferation -- Differentiation Capacity -- Cellular Transformation -- Mechanism of Action -- Cell Migration Toward Damaged Tissues |
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Tissue Repair -- Immunomodulatory Potential -- Preclinical Applications -- MSC-Based Therapy for Autoimmune Diseases -- MSCs for Cancer Treatment -- The Anti-tumor Activity of MSCs -- The Pro-tumor Activity of MSCs -- The Imprint of Disease on MSCs -- Considerations for Clinical Applications -- Safety Concerns -- Cell Manufacturing for Clinical Use -- Considerations for Cellular Medicament -- General Considerations -- Attempts to Improve the Therapeutic Outcomes of Cellular Medicament -- Concluding Remarks and Future Perspective -- Cross-References -- References |
| Summary |
The handbook comprehensively reviews the therapeutic potential of stem cells and stem cell secretome-based cell-free strategies in regenerative medicine. The chapters in section I and section II respectively discuss the diverse applications of mesenchymal stem cells and non- mesenchymal stem cells, including skeletal myoblasts, endothelial progenitor cells, adipose tissue-derived stem cells, induced pluripotent stem cells, and neuronal stem cells in myocardial repair, inflammatory bowel disease, cognitive deficits, wound healing, retinal disorders, and COVID-19. The subsequent chapters in section IIIprimarily focused on the fast-emerging cell-free therapy approach in regenerative medicine for tissue repair and regeneration. These chapters review the impact of stem cell-derived secretome on various biological processes such as angiogenesis, neurogenesis, tissue repair, immunomodulation, musculoskeletal pathologies, wound healing, anti-fibrotic, and anti-tumorigenesis for tissue maintenance and regeneration.Lastly, section IV summarizes miscellaneous aspects of cell-based therapy, includingthe treatment advantages, opportunities, and shortcomings in stem cell-based therapy, potentially helping to refine future studies and translate them from experimental to clinical studies. Moreover, this section also has chapters on cancer stem cells as novel targets in cancer therapeutics. This Major Reference Book (MRW) is a valuable resource for researchers involved in stem cell research to understand the multifaceted therapeutic applications of stem cells and their derivative secretome in regenerative medicine |
| Notes |
Includes index |
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Online resource; title from PDF title page (SpringerLink, viewed November 22, 2022) |
| Subject |
Stem cells -- Therapeutic use
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Stem cells -- Transplantation.
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Regenerative medicine.
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Regenerative medicine
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Stem cells -- Transplantation
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Cèl·lules mare.
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| Genre/Form |
Llibres electrònics.
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| Form |
Electronic book
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| Author |
Haider, Khawaja Husnain, editor.
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| ISBN |
9789811926556 |
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9811926557 |
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