| Description |
1 online resource |
| Series |
Translational epigenetics ; Volume 31 |
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Translational epigenetics series ; v. 31.
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| Contents |
Intro -- Epigenetics of Stress and Stress Disorders -- Copyright -- Contents -- Contributors -- Foreword -- Acknowledgments -- Chapter 1 The physiology of stress and the human body's response to stress -- Introduction -- Stress as an environmental factor -- The basics of the stress response -- Sympathetic and parasympathetic systems -- Allostasis and allostatic load -- Allostatic load and disease burden -- Allostatic load and the brain -- Cortisol as the primary driver of the chronic stress response -- Glucocorticoids and the brain -- Molecular mechanism of cortisol action -- Intracellular negative feedback and glucocorticoid resistance -- Epigenetics -- Effect of chronic stress on systemic cortisol dynamics -- Effect of chronic stress on neurotransmitter function and behavior -- Conclusion -- Acknowledgments -- References -- Chapter 2 Posttraumatic stress disorder: Diagnosis, measurement, and assessment -- Introduction to PTSD and stress-related disorders -- Proper diagnosis according to DSM-5 -- Risk factors for PTSD -- Comorbidities and complications of PTSD -- Differential diagnosis of PTSD -- PTSD vs acute stress disorder -- Tools for diagnosis -- Life events checklist for DSM 5 (LEC-5) -- PTSD checklist for DSM-5 (PCL-5) -- Clinician-administered PTSD scale 5 (CAPS-5) -- References -- Chapter 3 Nikola Tesla: An autobiographical case study of trauma and resilience -- Introduction a -- Nikola Tesla's mental symptoms and mental experiences -- References -- Chapter 4 Management of posttraumatic stress disorder -- Introduction -- Management algorithm -- Treatment algorithm -- Shared decision making -- The role of PTSD checklist-5 (PCL-5) in management -- Trauma-focused psychotherapies -- Prolonged exposure therapy -- Cognitive processing therapy -- Eye movement desensitization and reprocessing -- Specific cognitive-behavioral therapies for PTSD |
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Brief eclectic psychotherapy -- Narrative exposure therapy -- Written narrative exposure -- Second-line therapies -- Nontrauma-based psychotherapies -- Other psychotherapies -- First-line pharmacotherapies -- Second-line pharmacotherapies -- Medications to avoid in PTSD treatment -- Complementary and alternative techniques -- Internet-based and tele-therapies -- Management of PTSD comorbidities -- Summary -- References -- Chapter 5 Depression and epigenetics: Epidemiology, pathophysiology, diagnosis, and assessment -- Epidemiology -- Neurobiology and pathophysiology -- Genetic predisposition -- Environmental factors and gene-environment interactions -- Epigenetic mechanisms -- Pathophysiology -- Monoamine dysfunction -- Glutamate dysfunction -- Hypothalamic-pituitary-adrenal (HPA) axis dysfunction -- Immune system dysregulation -- Dysfunction of neuroplasticity and neurogenesis -- Circadian rhythm dysregulation -- Dysregulation of opioid and endocannabinoid systems -- Diagnosis and assessment -- Diagnostic criteria, classification, and symptomatology -- Major depressive disorder -- MDD subtypes and specifiers -- Comorbidities -- Suicide risk -- Screening, diagnosis, and measurement-based care -- Screening and diagnosis -- Measurement-based care -- References -- Chapter 6 Depression management and pharmacoepigenetics -- Principles of depression management -- General principles -- Treatment phases -- Measurement-based and evidence-informed care -- Stepped care and chronic disease management model -- Depression management strategies -- Suicide risk management -- Treatment selection -- Pharmacotherapy -- Antidepressant selection: Clinical factors -- Antidepressant selection: Nonclinical factors -- Management of partial or lack of response -- Monitoring and management of adverse reactions -- Psychotherapy -- Neurostimulation |
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Depression management in special populations -- Pharmacoepigenetics -- References -- Chapter 7 Psychotherapy for stress disorders: A military perspective -- Overview of behavioral health in the military health system -- Posttraumatic stress disorder -- Pretraumatic factors -- Peritraumatic factors -- Posttraumatic factors -- Treatment -- Psychotherapy for PTSD -- Prolonged exposure -- Cognitive processing therapy -- Eye movement desensitization and reprocessing -- Conclusion -- Depression -- Treatment -- Epigenetics and psychotherapy -- Conclusion -- References -- Further reading -- Chapter 8 How stress affects gene expression through epigenetic modifications -- Introduction-Biology of stress -- Epigenetics -- DNA methylation -- Histone modification and noncoding RNA -- Gene expression -- Stress-induced epigenetic and gene expression changes in animal models -- Stress-induced epigenetic modifications and gene expression changes in humans -- DNA methylation and gene expression changes of candidate genes -- Genome-wide studies of DNA methylation and gene expression changes -- Timing of stress is important-epigenetic modifications and gene expression changes at different times during life -- Epigenetic effects of stress in early life -- Epigenetic effects of stress in childhood -- Effects of stress in adulthood -- Transgenerational transmission of stress-induced epigenetic marks -- Limitations and future directions -- References -- Chapter 9 Proposed effect of epigenetic alterations on stress-related disorders -- Introduction -- Genetic background and mechanisms of stress-related disorders -- Genetic background of depressive disorders -- Genetic background of posttraumatic stress disorder -- From genetics to epigenetics -- Epigenetic mechanisms in the process of stress-related disorders -- The influences of psychosocial stress on an epigenetic level |
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Epigenetic correlates of stress-reducing interventions and psychotherapies -- Conclusion -- References -- Chapter 10 PTSD and physiology: The long-term effects of PTSD and relation to epigenetics, physical health, and chronic dis... -- Introduction -- PTSD and adverse physical health -- Epigenetic studies of PTSD and implications for physical health -- EWAS of PTSD -- Comparing EWAS study characteristics -- Replicated findings -- EWAS results and implications for physical health -- Nervous system-related genes -- Inflammation and immune-related genes -- Endocrine-related genes -- Cardiovascular-related genes -- Metabolic disease-related genes -- Summary -- PTSD and epigenetic aging -- Summary -- Future directions -- Conclusions -- References -- Chapter 11 Epigenomic biomarkers of posttraumatic stress disorder -- Introduction -- Genetics of PTSD -- Epigenetics of PTSD -- DNA methylation -- Accelerated epigenetic aging and PTSD -- Histone modifications -- Noncoding RNAs -- Toward the development of PTSD multiomics biomarkers -- Gaps, challenges, and future directions -- Acknowledgments -- References -- Chapter 12 Adversity across time: Do sensitive periods across the life span determine adversity-induced epigenetic changes? -- Introduction -- Studies by timing of stress exposure -- Prenatal -- Postnatal to preadolescence (0-12 years old) -- Adolescence (12-20 years old) -- Adulthood ( > -- 20 years old) -- Intergenerational -- Methodological considerations -- Summary and concluding remarks -- Funding -- References -- Chapter 13 PTSD, telomeres, and aging -- Introduction -- Methods -- Results -- Kang et al. 24 -- Kim et al. 25 -- Avetyan et al. 27 -- Connolly et al. 29 -- Roberts et al. 30 -- Bersani et al. 28 -- Boks et al. 26 -- Shalev et al. 31 -- Zhang et al. 22 -- Jergović et al. 19 -- Ladwig et al. 23 -- O'Donovan et al. 21 -- Malan et al. 20 |
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Discussion -- References -- Chapter 14 Accelerated aging in mood disorders -- Introduction -- Mood disorders -- Major depressive disorder -- Bipolar disorder -- Clinical evidence of accelerated aging in mood disorders -- Major depressive disorder -- Bipolar disorder -- Pathophysiology of accelerated aging in mood disorders -- Biological clock findings in mood disorders -- Major depressive disorder -- Bipolar disorder -- Antiaging effects of antidepressants and mood stabilizers -- Conclusions -- References -- Chapter 15 Epigenetics, stress, and depression -- Introduction -- Materials and methods -- Results -- Chan et al. 5 -- Hüls et al. 6 -- Humphreys et al. 7 -- Starnawska et al. 8 -- Zhu et al. 9 -- Boström et al. 10 -- Ciuculete et al. 11 -- Kuan et al. 12 -- Bustamante et al. 13 -- Kaut et al. 14 -- Dell'Osso et al. 15 -- Davies et al. 16 -- Weder et al. 17 -- Melas et al. 18 -- Numata et al. 19 -- Discussion -- References -- Chapter 16 Capturing the epigenome: Differences among blood, saliva, and brain samples -- Introduction -- Early days of research on neuropsychiatric epigenetics in animals and humans -- Comparison of DNA methylation among blood, saliva, and buccal samples -- Salivary DNA methylation analyses -- Salivary DNA methylation studies of PTSD and trauma -- Studies on correlations between brain and peripheral tissue DNA methylation and its databases -- Conclusion -- References -- Chapter 17 Posttraumatic stress disorder, major depressive disorder, and noncoding RNAs -- Introduction -- Posttraumatic stress disorder -- Major depressive disorder -- MicroRNAs -- Long noncoding RNAs -- MicroRNA and posttraumatic stress disorder -- MicroRNAs and major depressive disorder -- Long noncoding RNAs and posttraumatic stress disorder -- Long noncoding RNAs and major depressie disorder |
| Summary |
Epigenetics of Stress and Stress Disorders, Volume 31 in the Translational Epigenetics series, examines the epigenetic mechanisms involved in modifying DNA or gene expression following prolonged stress and/or trauma. Sections introduce both genetic and psychiatric foundations, including modes of epigenetic modification and gene expression that result from stress, as well as the medical knowledge required to understand stress related disorders and resilience. From here, chapters discuss epigenetic research techniques applied in recent studies, including epigenome-wide association studies (EWAS) of PTSD and resilience, the possible effects of prolonged stress on telomere shortening, and the long-term physical effects of PSTD. The book concludes by examining the possible effects of transgenerational stress-induced epigenetic alterations on the resilience of future offspring, the potential for epigenetic therapeutics, and public health implications. Examines the epigenetics of stress, trauma and related stress disorders Includes methods (e.g. EWAS), protocols and directions for further studies Connects new research to clinical practice and highlights implications for patient care, drug discovery and public health |
| Notes |
Online resource; title from PDF title page (ScienceDirect platform, viewed June 22, 2022) |
| Subject |
Stress (Physiology)
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Epigenetics.
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Epigenetics
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Stress (Physiology)
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| Form |
Electronic book
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| Author |
Youssef, Nagy A., editor
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| ISBN |
9780128230626 |
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0128230622 |
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