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Book Cover
E-book
Author Hirschfield, Gideon M

Title The liver in systemic disease : a clinician's guide to abnormal liver tests
Published Newark : John Wiley & Sons, Incorporated, 2023
©2023

Copies

Description 1 online resource (285 pages)
Contents Cover -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Preface -- Section 1 Introduction -- Chapter 1 Liver Tests -- Introduction -- The Reference Range -- The Standard Liver Function Tests -- Albumin -- Aspartate and Alanine Amino Transferase -- Alkaline Phosphatase -- Gamma-Glutamyl Transferase -- Bilirubin -- Prothrombin Time -- Other Analytes in Liver Disease -- Kidney Blood Tests -- Hematologic Analytes -- Markers of Malignancy -- Hepatitis Viral Markers -- Assessment of Hepatic Fibrosis -- Imaging -- Assessment of Liver Fat -- Assessment of Alcohol Use -- Functional Tests of Liver Function -- Liver Biopsy -- Models Assessing Prognosis in Liver Disease -- References -- Further Reading -- Section 2 Take-Home Primers: Managing Unexplained Abnormal Liver Tests -- Chapter 2 Primary Care -- Introduction -- Liver Disease in the UK -- Isolated Raised Liver Transaminase in a Healthy Individuals -- Non-alcoholic Fatty Liver Disease -- Alcohol and Liver Disease -- Chronic Infections of the Liver -- Hepatitis B Virus -- Hepatitis C Virus -- Hyperbilirubinemia -- Unconjugated Hyperbilirubinemia -- Conjugated Hyperbilirubinemia -- Neonatal Jaundice -- Physiological and Prolonged Jaundice -- Pathological Jaundice -- References -- Chapter 3 Global Perspective -- Introduction -- Indian Perspective -- Patterns of Specific Liver Disorders in the Indian Context -- Viral Hepatitis -- Hepatitis A Infection -- Hepatitis B Infection -- Hepatitis C -- Hepatitis D -- Hepatitis E -- Alcohol-Related Liver Disease -- Non-alcoholic Fatty Liver Disease -- Autoimmune Hepatitis -- Primary Biliary Cholangitis -- Wilson's Disease -- Drug-Induced Liver Injury -- Other Cholestatic Diseases -- Hemochromatosis -- Gilbert's Syndrome -- Non-hepatic Causes of Liver Enzymes Elevation -- Isolated Raised Alkaline Phosphatase -- Conclusions -- Far East Perspective
Africa Perspective -- Why Liver Disease in Primary Care? -- Liver Enzymes -- Common Causes of Raised Enzymes -- What to Do When a Patient Has Unexplained Liver Enzymes -- Clinical Features -- Relevant Investigations -- When to Refer -- Infections -- Liver Cirrhosis -- Drugs -- Issues to Note in Africa -- Conclusion/Take Home Message -- References -- Section 3 Take-Home Primers: Managing Unexplained Abnormal Serum Liver Tests in Secondary Care -- Chapter 4 Intensive Care -- Classification and Prevalence -- Patterns of Liver Test Abnormalities -- Hepatocellular Pattern of Liver Injury -- Principal Causes of Hepatocellular Liver Injury -- Cholestatic Pattern of Liver Injury -- Assessment of Severity of Liver Injury -- International Normalized Ratio -- Lactate -- Ammonia -- Albumin -- Sequential Clinical Assessment -- Approach to Supportive Care -- Discussion with a Specialist Liver Unit -- References -- Chapter 5 Infections Affecting the Liver in the Immunosuppressed -- Introduction -- Viral Infections -- Hepatitis A -- Hepatitis E -- Hepatitis B -- Hepatitis C -- Yellow Fever -- Dengue -- Epstein-Barr Virus -- Cytomegalovirus -- Herpes Simplex Virus -- Other Viral Infections -- Bacterial and Parasitic Infections -- Enteric Fever -- Brucellosis -- Leptospirosis -- Syphilis -- Lyme Disease, Q Fever, Rocky Mountain Spotted Fever -- Tuberculosis -- Schistosomiasis -- Malaria -- Fungal Infections -- Candida -- Aspergillosis -- Histoplasmosis -- Blastomycosis -- Cryptococcosis -- Conclusion -- Reference -- Further Reading -- Chapter 6 The Postoperative Patient -- Introduction -- Common Liver Problems Associated with the Postoperative Patient -- Common Postoperative Causes of a Predominant Hepatocellular Injury -- Common Postoperative Causes of a Predominantly Cholestatic Injury -- Unmasking Underlying Chronic Liver Conditions
Approach to Abnormal Liver Function Tests in the Postoperative Patient -- Imaging the Liver When Liver Function Tests are Deranged Postoperatively -- When Postoperative Abnormal Liver Function Tests are Unrelated to a Primary Liver Pathology -- References -- Chapter 7 Pregnancy -- Introduction -- Normal Pregnancy -- History -- Investigations -- Alkaline Phosphatase in Normal Pregnancy -- Abnormal Liver Tests Attributable to Pregnancy-Related Disease -- Hyperemesis Gravidarum -- Acute Fatty Liver of Pregnancy -- Hypertensive Disorders of Pregnancy -- HELLP Syndrome -- Distinguishing HELLP from Acute Fatty Liver of Pregnancy -- Intrahepatic Cholestasis of Pregnancy -- Ischemic Hepatitis -- Pre-existing Liver Disease -- Non-alcoholic Fatty Liver Disease -- Cirrhosis -- Liver Transplant -- Gall Bladder Disease -- Primary Biliary Cholangitis -- Primary Sclerosing Cholangitis -- Hereditary Hemochromatosis -- Wilson's Disease -- Acquired Non-Pregnancy-Related Disease -- Budd-Chiari Syndrome -- Drug-Induced Liver Injury -- Autoimmune Hepatitis -- Viral Hepatitis -- References -- Further Reading -- Chapter 8 Endocrinology and Metabolic Diseases (Including Diabetes) -- Introduction -- The Liver: Crossroads of Nutrient Homeostasis -- When Will the Endocrinologist See Unexplained Abnormal Liver Function Tests? -- Workup for Excluding Alternative Causes -- Abnormal Liver Function Tests in Patients with Known Endocrinology Disease -- Type 2 Diabetes Mellitus -- Thyroid Diseases -- Dyslipidemia -- Adrenal Diseases and the Liver -- When to Refer to a Liver Specialist -- References -- Further Reading -- Chapter 9 Abnormal Serum Liver Tests in Cardiac Disease -- Introduction -- Liver Disease Causing Heart Disease -- Cirrhotic Cardiomyopathy -- Heart Disease Causing Liver Disease -- Right-Sided Heart Failure and Hepatic Congestion -- Acute Heart Failure
Atrial Fibrillation -- Left-Ventricular Assist Devices and Cardiac Support Devices -- Liver Disease in Congenital Heart Disease -- Heart and Liver Disease Caused by a Common Disorder -- Infections -- Inflammatory Diseases -- Metabolic Diseases -- Liver Disease Unrelated to Heart Disease -- Drug-Induced Liver Injury -- References -- Further Reading -- Chapter 10 Respiratory Disease -- Lung Problems Due to Unexpected Liver Issues -- Arterial Hypoxemia -- Pulmonary Hypertension -- Pleural Effusions -- Liver-Lung Problems as Part of a "Systemic" Presentation -- Genetic Lung Abnormalities with Associated Abnormal Liver Tests -- Immunologic/Inflammatory Lung Disorders with Liver Manifestations -- References -- Chapter 11 Gastroenterology -- Abnormal Liver Tests in Gastroenterological Disease -- Pancreatobiliary Conditions -- Luminal Conditions -- Liver Diseases that may Mimic Gastroenterological Diseases -- Primary Sclerosing Cholangitis -- Liver Diseases Associated with Gastroenterological Diseases -- When to Refer -- Primary Sclerosing Cholangitis: Inflammatory Bowel Disease -- Secondary Sclerosing Cholangitis/Secondary Biliary Cirrhosis -- Take-Home Messages -- Unexplained Abnormal Liver Tests in Patients with Known Gastroenterological Diseases -- Take-Home Messages -- Monitoring Liver Blood Tests in Gastroenterology -- Liver Screen -- Further Reading -- Chapter 12 Renal Medicine -- Introduction -- Renal Impairment in Patients with Liver Disease -- Measurement of Renal Function in Patients with Cirrhosis -- Acute Kidney Injury in Patients with Liver Cirrhosis -- Chronic Kidney Disease in Patients with Liver Cirrhosis -- Renal Impairment in Patients with Acute Liver Failure -- Renal Impairment in Liver Transplant Recipients -- Abnormal Liver Enzymes in Patients with Kidney Disease -- Abnormal Liver Enzymes in Patients with Acute Kidney Injury
Abnormal Liver Enzymes in Patients with Chronic Kidney Disease -- Dialysis -- Liver Disease in Kidney Transplant Recipients -- Viral Hepatitis in Kidney Transplant Recipients -- References -- Chapter 13 Dermatology -- Introduction -- Dermatological Drugs and Liver Function Tests -- Methotrexate -- Retinoids -- Azathioprine -- Cyclosporin -- Antifungal Medication -- Chinese Herbal Medication -- When is Further Investigation Required? -- Liver Disease that Mimics Dermatological Diseases -- Primary Biliary Cholangitis -- Alcohol-Related Liver Disease -- Hepatitis C -- Hemochromatosis -- Liver Disease Associated with Dermatological Disease -- Psoriasis -- Sarcoidosis -- Lichen Planus -- Dermatitis Herpetiformis -- Mastocytosis -- Dermatological Malignancies -- Neurofibromatosis -- Other Dermatology Conditions -- Unexplained Abnormal Liver Function Tests in Patients with Known Dermatological Disease -- References -- Chapter 14 Oncology -- Liver Diseases That May Mimic Oncologic Diseases -- Liver Diseases Associated with Oncologic Diseases -- Liver Enzyme Elevations -- Chemotherapy-Associated Steatohepatitis -- Hepatic Sinusoidal Injury -- Nodular Regenerative Hyperplasia -- Immune-Mediated Hepatitis -- Radiation-Associated Liver Injury -- Hepatitis B Virus Reactivation -- Unexplained Abnormal Liver Tests in Patients with Known Oncologic Disease -- At Diagnosis -- During Therapy -- After Therapy -- Summary -- References -- Chapter 15 Hematology -- Introduction -- Unexplained Abnormal Liver Tests in Patients with Known Hematologic Disease -- References -- Chapter 16 Mental Health and Neurology -- Introduction -- Unexplained Abnormal Liver Function Tests in Mental Health and Neurology Settings -- Antidepressants -- Antipsychotics -- Liver Diseases that May Mimic Psychiatric Conditions -- Liver Diseases Associated with Psychiatric Disease
Notes Unexplained Abnormal Liver Function Tests in Patients with Known Psychiatric Disease
Description based on publisher supplied metadata and other sources
Form Electronic book
Author Gill, Paramjit
Neuberger, James
ISBN 1119802180
9781119802181
1119802164
9781119802167