| Description |
1 online resource |
| Contents |
880-01 Front Cover; BIOLOGY AND ENGINEERING OF STEM CELL NICHES; BIOLOGY AND ENGINEERING OF STEM CELL NICHES; Copyright; Contents; List of Contributors; Foreword; 1 -- Biology of Stem Cell Niches and Molecular Mechanisms; 1 -- The Need to Study, Mimic, and Target Stem Cell Niches; 1. INTRODUCTION; 1.1 The Stem Cell Niche in Health and Disease; 1.2 Components of Stem Cell Niche; 2. BIOLOGY OF THE STEM CELL NICHE; 2.1 Behavior of Stem Cells: Hierarchical Versus Stochastic Model; 2.2 Embryonic and Adult Stem Cell Niches; 3. BIOCHEMICAL AND BIOPHYSICAL REGULATION OF STEM CELL BEHAVIOR |
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880-01/(S 1. INTRODUCTION2. ORGANIZATION OF HEMATOPOIETIC STEM CELL NICHE IN THE BONE MARROW; 3. NICHE SIGNALING; 3.1 Transformation Growth Factor Beta and Bone Morphogenic Pathway Signaling; 3.1.1 Transforming Growth Factor-β Signaling; 3.1.2 BMP Signaling; 3.2 Wnt Signaling; 3.2.1 Canonical Wnt Signaling; 3.2.2 Noncanonical Wnt Signaling; 3.3 Growth Factors, Cytokines, and Chemokines; 3.3.1 c-Kit-Stem Cell Factor Signaling; 3.3.2 CXCL12-Cxcr4/Stromal Cell-Derived Factor 1 Signaling; 3.3.3 Angiopoietin1; 3.3.4 Osteopontin and Thrombopoietin; 3.4 Notch Signaling and Hedgehog Signaling |
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3.1 Extracellular Matrix and Biochemical Cues3.2 Soluble Growth Factors and Ligands; 3.3 Physical Cues and Matrix Mechanics; 3.4 Oxygen and Metabolism; 3.5 Immune Cells, Inflammation, and Immunomodulation; 4. MIMICKING THE STEM CELL NICHE: BIOENGINEERING TOOLS AND TECHNIQUES; 5. BIOENGINEERING SPECIALIZED ARTIFICIAL STEM CELL NICHES FOR CLINICAL THERAPIES; References; 2 -- Harnessing the Biology of Stem Cells' Niche; 1. INTRODUCTION; 2. COMPONENTS OF THE STEM CELL NICHE; 2.1 Cellular Components; 2.2 Noncellular Components; 3. INTEGRATIVE NETWORKS REGULATING THE NICHE |
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4. DISTINCT NICHES FOR DIFFERENT STAGES OF DIFFERENTIATION5. NEOPLASTIC TRANSFORMATION AND DISTURBANCE OF THE TISSUE ECOSYSTEM; 6. CONCLUSION; ABBREVIATIONS AND ACRONYMS; Glossary; References; 3 -- Pluripotent Stem Cell Microenvironment; 1. INTRODUCTION; 2. PLURIPOTENT CELL MICROENVIRONMENT IN THE EARLY MAMMALIAN EMBRYO; 2.1 Lineage Specification in the Preimplantation Embryo; 2.2 Role of Extraembryonic Cells in Development of the Pluripotent Cells; 2.2.1 Interactions Between Inner and Outer Blastomeres During the ICM Versus TE Specification and Associated Signals |
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2.2.2 Cellular Interplay Between the PrE and the Epiblast3. MICROENVIRONMENT OF PLURIPOTENT STEM CELLS IN VITRO; 3.1 Derivation of Embryonic Stem Cells; 3.2 Cellular Heterogeneity in Mouse ESC Cultures; 3.3 Epigenetic Mechanisms Underlying Metastable States of Mouse ESCs; 3.4 Heterogeneity of Human ESC Culture; 3.5 Functional and Epigenetic Distinctions Between Human ESC Subfractions; 3.6 Regulatory Niche in Human ESC Culture; 4. CONCLUSION; ABBREVIATIONS AND ACRONYMS; Glossary; Acknowledgment; References; 4 -- Regulation of Hematopoietic Stem Cell Dynamics by Molecular Niche Signaling |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Vendor-supplied metadata |
| Subject |
Stem cells.
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Stem Cell Niche
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Stem Cells
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SCIENCE -- Life Sciences -- Cell Biology.
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Stem cells
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| Genre/Form |
Electronic books
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| Form |
Electronic book
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| Author |
Vishwakarma, Ajaykumar, editor.
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Karp, Jeffrey, editor.
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| LC no. |
2017302976 |
| ISBN |
9780128027561 |
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0128027568 |
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