| Description |
1 online resource : illustrations |
| Contents |
The Cell Biology of Exosomes: Historical and Perspectives / Alessandra Lo Cicero and Graça Raposo -- The Role of Exosomal Shuttle RNA (esRNA) in Cell-to-Cell Communication / Cecilia Lässer, Maria Eldh and Jan Lötvall -- Exosomal Lipids in Cell-Cell Communication / Michel Record -- The Functional Importance of Tetraspanins in Exosomes / Sanyukta Rana and Margot Zöller -- The Effects of Exosomes and Related Vesicles on Cancer Development, Progression, and Dissemination / William E. Grizzle and Huang-Ge Zhang -- Circulating Cell-derived Vesicles Mediate Tumor Progression / Douglas D. Taylor and Gercel-Taylor Cicek -- Immune Modulation of T Cells and Natural Killer Cells by Tumor-Derived Exosomes / Theresa L Whiteside -- The Role of Tumor Exosomes in Tumorigenicity / Huang-Ge Zhang and Johan K.O. Skog -- Microenvironmental Regulation of Metastasis by Exosomes / Haiying Zhang, Guillermo Garcia-Santos, Héctor Peinado and David C. Lyden -- Microvesicles and Their Emerging Role in Cellular Therapies for Organ and Tissue Regeneration / Mariusz Z. Ratajczak, Kasia Mierzejewska, Magda Kucia, Nick Greco and Janina Ratajczak |
| Summary |
Tumor exsome-mediated cell-cell communication has grown increasingly important in cancer research. Recent findings on vesicle-based information transfer by exosomes have changed our view of the tumor microenvironment. Currently, exosomes represent the main extracellular processes implicated in the regulation of multiple physiological processes. Importantly, in cancer, exosomes contribute to the formation of the tumor microenvironment, promoting invasion, angiogenesis, immune regulation and metastasis. Therefore, exosomes could be considered one of the major forces acting locally or systemically to promote the continuous crosstalk between the tumor and its microenvironment, influencing the behavior of different cell types such as stromal, endothelial and bone marrow-derived cells. Given the ability of exosomes to export unneeded endogenous molecules from cells, these structures hold great potential as anticancer therapeutic agents. This volume gives a comprehensive review on current research in this area and also discuss future prospects as prognostic markers for cancer |
| Analysis |
Medicine |
|
Oncology |
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Immunology |
|
Post-translational modification of proteins |
|
Cytology |
|
Cancer Research |
|
Cell Biology |
|
Protein Science |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
| In |
Springer eBooks |
| Subject |
Tumors -- Genetic aspects.
|
|
Cell interaction.
|
|
Tumor proteins.
|
|
Cancer cells.
|
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Biochemistry.
|
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Neoplasms -- genetics
|
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Cell Communication
|
|
Neoplasm Proteins
|
|
Biochemistry
|
|
biochemistry.
|
|
SCIENCE -- Life Sciences -- Anatomy & Physiology.
|
|
Cancer cells
|
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Cell interaction
|
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Tumor proteins
|
|
Tumors -- Genetic aspects
|
| Form |
Electronic book
|
| Author |
Zhang, Huang-Ge
|
| LC no. |
2012948293 |
| ISBN |
9781461436973 |
|
1461436974 |
|
1461436966 |
|
9781461436966 |
|
1283613212 |
|
9781283613217 |
|
9786613925664 |
|
6613925667 |
|
