| Description |
1 online resource |
| Contents |
Front Cover -- Autophagy -- Copyright Page -- Dedication -- Mitophagy and Biogenesis -- Autophagy and Cancer -- Some Thoughts on Autophagy and Immunity -- Autophagy: Friend or Foe? -- Autophagy: If and When -- What Happened When Autophagy Didn't -- Sugar Isn't Always Sweet -- Mitochondrial Mysteries -- A Photo Is Static, An Instant in Time -- Autophagy Subversion -- Contents -- Foreword by Roberta A. Gottlieb -- Foreword by Eeva-Liisa Eskelinen -- Preface -- Contributors -- Autophagy: Volume 1 -- Contributions -- Autophagy: Volume 2 -- Contributions -- Autophagy: Volume 3 -- Contributions -- Autophagy: Volume 4 -- Contributions -- Autophagy: Volume 5 -- Contributions -- Autophagy: Volume 6 -- Contributions -- Autophagy: Volume 7 -- Contributions -- Autophagy: Volume 8 -- Contributions -- I. MOLECULAR MECHANISMS -- 1 Overview of Autophagy -- Specific Functions of Autophagy (A Summary) -- Autophagy in Normal Mammalian Cells -- Endoplasmic Reticulum -- Endoplasmic Reticulum Stress -- Major Types of Autophagies -- Macroautophagy (Autophagy) -- Microautophagy -- Chaperone-Mediated Autophagy -- Autophagosome Formation -- Autophagic Lysosome Reformation -- Protein Synthesis -- Methods -- Abnormal Proteins -- Molecular Chaperones -- The Endoplasmic Reticulum -- Endoplasmic Reticulum and Apoptosis -- Autophagic Proteins -- Protein Degradation Systems -- Beclin-1 -- Nonautophagic Functions of Autophagy-Related Proteins -- Microtubule-Associated Protein Light Chain 3 -- Aggrephagy -- Aggresome, Ubiquitin Proteasome, and Autophagic Systems -- Monitoring Autophagy -- Reactive Oxygen Species (ROS) -- Mammalian Target of Rapamycin (mTOR) -- Role of Autophagy in Tumorigenesis and Cancer -- Role of Autophagy in Immunity -- Autophagy and Senescence -- Role of Autophagy in Viral Defense and Replication -- Role of Autophagy in Intracellular Bacterial Infection |
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Role of Autophagy in Heart Disease -- Role of Autophagy in Neurodegenerative Diseases -- Cross-Talk Between Autophagy and Apoptosis -- Autophagy and Ubiquitination -- Autophagy and Necroptosis -- Mitochondrial Fusion and Fission -- Selective Autophagy -- Allophagy -- Axonophagy (Neuronal Autophagy) -- Chromatophagy -- Ciliophagy -- Crinophagy -- Exophagy -- Glycophagy -- Lipophagy -- Lysophagy -- Mitophagy -- Nucleophagy -- Pexophagy -- Role of Pexophagy in Yeast -- Reticulophagy -- Ribophagy -- Xenophagy -- Zymophagy -- References -- 2 Autophagic Structures in Yeast -- Introduction -- Autophagic Bodies -- Autophagosomes -- Cvt Vesicles and Cvt Bodies -- Pre-Autophagosomal Structure and Isolation Membranes -- Pre-Autophagosomal Structure -- PAS for Selective and Nonselective Autophagy -- Isolation Membranes -- Membrane Structures Involved in Pexophagy in P. pastoris -- Atg9 Vesicles -- Atg9 is an Integral Membrane Protein that Traffics through the Secretory Pathway -- Atg9 Trafficking in Mutants of the Transport Protein Particle III Complex -- Atg9 Trafficking in Mutants Defective in Golgi Functions -- Atg9 Trafficking in Mutants Defective in Exocytic Secretion -- PtdIns Phosphates in Atg9 Trafficking -- Membrane Contact Sites Involved in Autophagy -- Concluding Remarks -- Acknowledgments -- References -- 3 Mitophagy: Sensors, Regulators, and Effectors -- Introduction -- PINK1-Parkin Mitophagy Pathway: A Partnership between Sensor and Regulator Proteins -- Mitophagy Effectors -- FUNDC1 -- NIX/BNIP3L -- BNIP3 -- SMURF1 -- Conclusions -- Acknowledgments -- References -- 4 Regulation of Autophagy by Actin-Associated Signaling Pathways -- Introduction -- Roles for Actin in Autophagy: Evidence From Yeast -- ROCK Regulation of Autophagosome Formation -- ROCK Regulation of Beclin 1 for Autophagy Induction -- Activation of Beclin 1 at the Actin Cytoskeleton |
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A Role for Myosin II During Early Stages of Autophagy -- Role for Myosin VI During Late Stages of Autophagy Maturation -- Role for Myosin VI During Early Autophagosome Formation -- WASH Regulation of Endosome Trafficking -- WASH Regulation of Ubiquitination -- Convergence of WASH and Ambra1 Pathways -- Conclusions -- References -- 5 G2019S Mutation of LRRK2 Increases Autophagy via MEK/ERK Pathway -- Introduction -- Role of Autophagy in Parkinson's Disease -- Genetic and Environmental Factors in PD -- Leucine-Rich Repeat Kinase 2 (LRRK2) -- Protein Structure and Function of LRRK2 -- Pathogenic LRRK2 Mutations -- LRRK2 G2019S -- Role of LRRK2 in Autophagy -- Autophagy Dysregulation in G2019S LRRK2 -- Susceptibility of G2019S LRRK2 Fibroblasts to MPP+ -- Acknowledgments -- References -- 6 Cargo Proteins Facilitate the Formation of Transport Vesicles, but not Autophagosomes -- Introduction -- Cargo Proteins of the Cvt Pathway -- Receptors for the Cvt Pathway -- Mechanism of APE1 Targeting to the PAS -- Cargo-Dependent Organization of the PAS and Formation of Transport Vesicles -- Regulation of the Cvt Vesicle Formation -- Conclusions -- Acknowledgments -- References -- 7 Absence of Bax and Bak: Implications for Autophagy and Alternative Mitochondrial Functions -- Introduction -- Mitochondria and Mitochondrial Pore Opening in Apoptosis -- Function of Bax and Bak Proteins -- Bax and Bak in Skeletal Muscle -- Novel Mitochondrial Roles for Bax and Bak -- Acknowledgments -- References -- 8 The Antiapoptotic Protein BCL-2 Has Also an Antiautophagy Role Through Beclin 1 Inhibition -- Discovery of the Beclin 1-BCL-2 Interaction -- Role and Regulation of the Beclin-1-BCL-2 Interaction in Autophagosome Formation -- Regulation of the Beclin 1-BCL-2 Interaction by Extracellular Cues and Subsequent Posttranslational Modifications |
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Role of BCL-2 Intracellular Localization -- The Beclin 1-BCL-2 Interaction Is Affected by Their Many Partners -- Role of the Beclin-1-BCL-2 Interaction in Physiopathology -- Cell Death -- Exercise -- Immunity/Virology -- Neurodegeneration -- Cancer -- Conclusion -- Acknowledgments -- References -- 9 Organic Pollutant Perfluorooctane Sulfonate-Induced Lysosomal Membrane Permeabilization Blocks Autophagy Flux in Human He ... -- Introduction -- PFOS Blocked Autophagosome Degradation in HepG2 Cells -- PFOS Caused Autophagosome Accumulation in HepG2 Cells -- PFOS Increased the Expression of LC3-II and P62 in HepG2 Cells -- Chloroquine Did Not Further Increased the Expression of LC3-II in LC3 Turnover Assay -- PFOS Induced LMP in HepG2 Cells -- PFOS Caused Autophagic Cell Death in HepG2 Cells -- Discussion -- Acknowledgments -- References -- II. AUTOPHAGY AND CANCER -- 10 Mutant p53 Located in the Cytoplasm Inhibits Autophagy -- Introduction -- Overview of the Autophagic Pathway -- Mechanisms of Autophagy Regulation -- Autophagy and Cancer Development -- The Tumor Suppressor p53 -- p53 and Autophagy -- Nuclear p53 and Autophagy Regulation -- Cytoplasmic p53 and Autophagy Regulation -- Conclusion -- Acknowledgments -- References -- 11 Role of Autophagy in Regulation Survival or Death of Cancer Cells -- Introduction -- Common Oncogenic Signals of Autophagy -- TP53 -- Death-Associated Protein Kinase Family -- ARF Isoforms -- PI3K/Akt/mTOR Pathway -- Stress Mediators: ROS, Ca2+, Mitochondrial, and ER Stress -- Autophagy Regulates Survival of Cancer Cells -- Activation of Autophagy in the Regulation of Cancer Cell Survival -- Inhibition of Autophagy in Regulation of Cancer Cell Survival -- Autophagic Cell Death in Cancer Cells -- Autophagy Regulates Cancer Development -- Anticancer Therapeutic Application of Autophagy -- Discussion -- References |
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12 Regulation of Autophagy in Chronic Lymphocytic Leukemia: The Role of Histone Deacetylase Inhibitors -- Introduction -- Chronic Lymphocytic Leukemia: An Overview -- Autophagy at a Glance -- Basal Autophagy in CLL -- The Role of PI3K/AKT/mTOR Pathway -- The Role of CXCL12/CXCR4 Signaling -- The Role of the Antiapoptotic BCL-2 Family Proteins -- The Role of p53 -- The Role of microRNAs -- Evidence for Basal Autophagy as an Active Pro-Survival Process -- Pharmacological Modulation of Autophagy in CLL -- Activation of Autophagy as a Pro-Survival Mechanism in Primary CLL Cells -- Activation of Autophagy as a Pro-Death Mechanism in Primary CLL Cells -- Overview of HDAC Inhibitors and Their Anticancer Effects -- Histone Acetylation and Deacetylation in Cancer -- Classification of HDACs -- Classification of HDAC Inhibitors -- HDAC Inhibitors in Clinic and Clinical Trials for Anticancer Therapy -- Anticancer Activity of HDAC Inhibitors -- HDAC Inhibitors and Autophagy -- Mechanisms of HDAC Inhibitor-Mediated Autophagy -- The Pro-Death and Pro-Survival Effects of HDAC Inhibitor-Elicited Autophagy -- HDAC Inhibitors as Autophagy Suppressors -- Conclusions and Perspectives -- References -- 13 Improving the Survival of Mesenchymal Stromal Cells Against Oxidative Stress in Transplantation: Role of Autophag ... -- Introduction -- Autophagy -- Mesenchymal Stromal Cells -- Stem Cell and Autophagy -- Role of Autophagy Induction in MSCs Under Oxidative Stress -- Dynamic Autophagic Flux in BMSCs Under Oxidative Stress -- Prolonged Oxidative Exposure Enhances Apoptosis in BMSCs -- Autophagy Manipulation Regulates the Cell Survival of BMSCs -- Discussion -- Conclusions -- Acknowledgments -- References -- III. AUTOPHAGY AND INFECTION -- 14 Low-Density Lipoprotein Receptor-Related Protein-1 Mediates Vacuolating Cytotoxin-Induced Autophagy and Apoptosi ... -- Introduction |
| Notes |
Includes index |
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Online resource; title from PDF title page (ScienceDirect, viewed June 30, 2016) |
| Subject |
Autophagic vacuoles.
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Cell death.
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SCIENCE -- Life Sciences -- Anatomy & Physiology.
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Autophagic vacuoles
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Cell death
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| Form |
Electronic book
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| Author |
Hayat, M. A., 1940- editor.
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| ISBN |
9780128094280 |
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0128094281 |
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