| Description |
1 online resource (920 pages) |
| Contents |
Cover; Related Titles; Title page; Copyright page; Dedication; Preface; List of Contributors; 1.1 Introduction; 1.2 Melanosome Research in the Pre-Seiji Era; 1.3 Melanosome Research in the Seiji Era; 1.4 Melanosome Research in the Post-Seiji Era; 1.5 Other Historical Aspects; Acknowledgments; 1 History of Melanosome Research; 2.1 Definition of Melanogenic Cells; 2.2 Distribution and Function of Melanogenic Cells; 2.3 Embryonic Development of Melanogenic Cells; 2.4 Transfer of Melanin from Classical and Nonclassical Melanocytes; 2 Classical and Nonclassical Melanocytes in Vertebrates |
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3.1 General Biological Significance of o-Quinones3.2 o-Quinone Reactivity; 3.3 Role of o-Quinones in Melanogenesis; 3 Biological Chemistry of o-Quinones; 4.1 Introduction; 4.2 Raper-Mason Pathway; 4.3 Structural and Functional Properties of the Melanogenic Enzymes; 4.4 Regulation of the Melanogenic Pathway; 4.5 Conclusions and Perspectives; Acknowledgments; 4 Biosynthesis of Melanins; 5.1 Introduction; 5.2 Depigmenting Agents; 5.3 Enhancers of Melanogenesis; 5 Inhibitors and Enhancers of Melanogenesis; 6.1 Introduction; 6.2 Classification and General Properties of Melanins |
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6.3 Biosynthetic Studies6.4 Degradative Studies; 6.5 Analysis of Eumelanins and Pheomelanins; 6.6 Conclusions; 6 Structure of Melanins; 7.1 Introduction; 7.2 Biogenesis of Ocular Melanosomes and Melanogenesis; 7.3 Melanin Content in Pigmented Structures of the Eye; 7.4 Structure of Ocular Melanosomes; 7.5 Role of Ocular Melanin as a Broadband Optical Filter; 7.6 Antioxidant Properties of Ocular Melanin; 7.7 Pro-Oxidant Properties of Ocular Melanosomes; 7.8 Other Properties of Ocular Melanosomes and Their Implications; 7.9 Conclusions |
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7 Properties and Functions of Ocular Melanins and Melanosomes8.1 What are Neuromelanins?; 8.2 Phylogenetic Development of Neuromelanin; 8.3 Development and Metabolism of Neuromelanin; 8.4 Structure of Neuromelanin; 8.5 Biological Role of Neuromelanin in the Human Brain; 8.6 Is Neuromelanin Involved in Neurological Disease?; 8.7 Effects of Neuromelanin In Vitro and In Vivo; 8.8 Conclusions; Acknowledgments; 8 Biological Role of Neuromelanin in the Human Brain and Its Importance in Parkinson's Disease; 9.1 Introduction; 9.2 Melanosomes: Intracellular Organelles Specialized in Melanin Synthesis |
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9.3 Endocytic System and Formation of Melanosomes9.4 Melanosome Maturation: Cargo Sorting to Mature Melanosomes; 9.5 Conclusions; Acknowledgments; 9 Biogenesis of Melanosomes; 10.1 Introduction; 10.2 Model Systems to Study Pigment Transport; 10.3 Intracellular Melanosome Transport; 10.4 Melanosome Motility in RPE: The Rab27a-Myrip-Myo7a Tripartite Complex; 10.5 Melanosome Transfer; 10.6 Fate of Melanin in the Keratinocyte; 10.7 Conclusions; Acknowledgments; 10 Transport and Distribution of Melanosomes; 11.1 Introduction |
| Summary |
The surface pigmentation of vertebrates is controlled by specialized cells able to synthesize a variety of pigments collectively known as melanins. Recent research has shown that melanins are produced not only in the skin but also in many other sites such as the eye, inner ear, muscles, etc., - where they are engaged in some unanticipated roles. The details of the synthetic pathway, the complexities of its regulation and biological significance that have been unravelled in recent research comprise a fascinating story and are of key importance in understanding the nature of diseases, includin |
| Notes |
11.2 Genes Involved in Melanoblast Development, Migration, and Specification |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Print version record |
| Subject |
Melanins.
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Melanoma.
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Melanins -- physiology
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Melanosomes -- physiology
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Melanoma -- pathology
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Melanins
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Melanoma
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melanin.
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SCIENCE -- Life Sciences -- Biochemistry.
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Melanins
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Melanoma
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| Form |
Electronic book
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| Author |
Borovansky, Jan
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| LC no. |
2012397479 |
| ISBN |
9783527636143 |
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3527636145 |
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3527328920 |
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9783527328925 |
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3527644555 |
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9783527644551 |
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1283835363 |
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9781283835367 |
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