| Description |
1 online resource (200 pages) |
| Contents |
Front Cover -- Tumor Vascularization -- Copyright Page -- Contents -- List of contributors -- Preface -- 1 Sprouting and nonsprouting angiogenesis in tumors -- Introduction -- The angiogenic switch -- Sprouting tumor angiogenesis -- Intussusceptive microvascular growth angiogenesis -- Glomeruloid vascular proliferation -- Concluding remarks -- References -- 2 Nonangiogenic tumor growth -- Introduction -- Identification of nonangiogenic tumors -- Alveolar growth pattern -- Lepidic growth pattern -- Interstitial growth pattern -- Perivascular (cuffing) growth pattern |
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The biology of nonangiogenic growth -- Hypoxia and angiogenesis -- Inflammation and immune response -- Motility, invasion, and cell-cell adhesion -- Energy metabolism -- What causes tumors to grow in an angiogenic or nonangiogenic, vessel co-opting way? -- Blood vessels change when they are co-opted by malignant cells -- Conclusion -- References -- 3 Vascular co-option -- Vascular co-option in normal and transformed cells -- Vascular co-option in non-cancer cells -- Vascular co-option in cancer cells -- Molecular regulation of vascular co-option |
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Molecular regulation of cell adhesion and proliferation in vascular co-option -- Molecular regulation of migration and invasion linked to vascular co-option -- Molecular regulation of dormancy, latency, and awakening linked to vascular co-option -- Preclinical applications to target vascular co-option: prevention of metastasis -- Acknowledgments -- References -- 4 Pericyte mimicry: an embryogenesis-derived program of extravascular tumor cell migration -- Introduction -- Interactions between tumor cells and blood vessels -- History -- Angiotropism, PM and EVMM -- PM in melanoma -- Histopathology |
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Histological criteria -- Melanoma liver metastases -- Experimental models of PM -- Prognostic significance of angiotropism and PM -- Molecular findings -- Angiotropism, PM, and EVMM in non-melanoma tumors -- Molecular studies -- Laminin and cancer cell migration -- Laminins in melanoma -- Laminins in non-melanoma tumors -- Modulation of laminins in embryogenesis and in cancer progression -- PM and EVMM: Reversion to an embryogenesis-derived program -- Analogies between embryogenesis and cancer development -- Neural crest cell migration: a model for PM/EVMM -- Angiogenesis -- Cell competition |
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PM and EVMM: routes, direction and timing according to an embryogenesis-derived program -- Space, direction, and timing -- Perspectives and therapeutic implications -- Detection of PM and EVMM -- Therapeutic perspectives -- DAN -- YAP signaling -- Laminins -- Concluding remarks -- PM and vascular co-option: complementary embryonic phenomena? -- Acknowledgments -- References -- 5 Vasculogenic mimicry -- Introduction -- Vasculogenic mimicry in prognosis and progress -- Molecular pathway of vasculogenic mimicry -- Hypoxia/hypoxia-inducible factor pathway -- Vascular endothelial-cadherin pathway |
| Notes |
Long noncoding RNAs pathway |
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Includes index |
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Print version record |
| Subject |
Tumors -- Blood-vessels.
|
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Blood-vessels.
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Neoplasms -- blood
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Blood Vessels
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Tumors -- Blood-vessels
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| Form |
Electronic book
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| Author |
Ribatti, Domenico, 1956-
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Pezzella, Francesco.
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| ISBN |
0128220279 |
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9780128220276 |
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