| Description |
1 online resource (280 p.) |
| Contents |
Front cover -- Half title -- Title -- Copyright -- Contents -- Contributors -- Chapter 1 Epidemiology and clinical features of celiac disease in adults -- 1.1 Introduction -- 1.2 Initial epidemiological studies based on clinical symptoms -- 1.3 Modern epidemiological study based on the serological test -- 1.4 Global prevalence of CeD -- 1.5 Global seroprevalence of CeD -- 1.6 Global prevalence of biopsy-confirmed CeD -- 1.7 Prevalence of CeD by gender and age -- 1.8 Continent wise prevalence of CeD -- 1.8.1 CeD in Europe -- 1.8.2 Celiac disease in America (North and South America) |
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1.8.3 Prevalence of CeD in Oceania -- 1.8.4 Prevalence of CeD in Africa -- 1.8.5 Prevalence of CeD in Asia -- 1.8.6 Increase in the global prevalence of CeD over time -- 1.8.7 Increase in the incidence of CeD -- 1.8.8 Spectrum of clinical manifestations of CeD -- 1.8.9 Gastrointestinal manifestations (Classical CeD) -- 1.9 Extra-intestinal manifestations of CeD (Table 1.2 and Table 1.3) -- 1.9.1 Hematological manifestations -- 1.9.2 Endocrinological manifestations -- 1.9.3 Skeletal manifestations (osteopenia and osteoporosis) -- 1.9.4 Hepatic manifestations -- 1.9.5 Metabolic manifestations |
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1.9.6 Dermatological manifestations -- 1.9.7 Reproductive manifestations -- 1.9.8 Neuropsychiatric manifestations -- 1.9.9 Oral cavity and dental manifestations -- 1.10 Mortality in celiac disease -- References -- Chapter 2 Pediatric coeliac disease -- 2.1 Introduction: Distinct features of pediatric coeliac disease -- 2.2 Clinical presentation -- 2.3 Diagnosis -- 2.4 Screening of children for coeliac disease -- 2.5 Treatment and monitoring of paediatric coeliac disease -- 2.6 Toward primary prevention of coeliac disease? -- 2.7 Summary -- References |
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Chapter 3 Pathogenesis of coeliac disease -- a disorder driven by gluten-specific CD4+ T cells -- 3.1 Inductive and effector sites within the gut immune system -- 3.2 Induction of adaptive immune response to gluten -- 3.2.1 Involvement HLA II molecules -- 3.2.2 Transglutaminase 2 in CeD -- 3.2.3 Gluten: The driver of T-cell response -- 3.2.4 Gluten trafficking from lumen to lamina propria -- 3.2.5 Antigen presenting cells in the lamina propria presenting gluten -- 3.3 Gluten-specific CD4+ T cells -- 3.3.1 HLA-DQ:gluten tetramers -- 3.3.2 TCR recognition of gluten |
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3.3.3 Molecular mimicry between gluten T-cell epitopes and bacterial peptides -- 3.4 Functional role of gluten-specific CD4+ T cells -- 3.4.1 Phenotype of gluten-specific CD4+ T cells -- 3.4.2 Cytokine production -- 3.4.3 T cell and B cell interaction: Antibody production and T-cell clonal expansion -- 3.4.4 CD4+ T-cell help to intraepithelial lymphocytes (IELs) -- 3.4.5 Mechanisms underlying villous blunting in CeD -- 3.5 Concluding remarks -- References -- Chapter 4 Seronegative villous atrophy -- 4.1 Introduction -- 4.2 Seronegative coeliac disease |
| Notes |
Description based upon print version of record |
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4.3 Immunomediated non-coeliac enteropathies |
| Form |
Electronic book
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| Author |
Sanders, David S
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| ISBN |
9780128215722 |
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0128215720 |
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