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Book Cover
E-book
Author Zhao, Yutong

Title Lung Biology and Pathophysiology
Published Milton : Taylor & Francis Group, 2024

Copies

Description 1 online resource (291 p.)
Series Methods in Signal Transduction Series
Methods in signal transduction.
Contents Cover -- Half Title -- Series -- Title -- Copyright -- Contents -- Preface -- Acknowledgments -- Contributors -- Part I Lung Health and Pulmonary Diseases -- Chapter 1 Antimicrobial Peptides in Lung Health and Pulmonary Diseases -- 1.1 Introduction -- 1.2 Overview of Infectious Pulmonary Disease -- 1.2.1 Burden of Respiratory Infections -- 1.2.2 Pathogenesis of Lung Infections -- 1.2.3 Roles of Lung Infections on Exacerbations -- 1.3 Introduction to AMPs -- 1.4 AMPs in the Lung Environment -- 1.5 AMPs and Host Defense -- 1.5.1 AMP Modes of Action -- 1.5.2 AMPs against Bacterial Pathogens
1.5.3 AMPs against Viral Pathogens -- 1.6 AMPs and Immunomodulation -- 1.7 Bacterial Resistance Mechanisms to AMPs -- 1.7.1 Production of Proteases and "Trapping" Molecules -- 1.7.2 Capsule Production -- 1.7.3 Cell Membrane Charge Neutralization -- 1.7.4 Cell Membrane Fluidity -- 1.7.5 Efflux Pumps -- 1.7.6 Biofilm Formation -- 1.8 Future Directions for AMP Development -- 1.8.1 AMPs as Novel Drug Therapies for Pulmonary Diseases -- 1.8.2 Anticancer Activity of AMPs -- 1.8.3 AMPs and Cancer Immunotherapy -- 1.9 Conclusions -- Abbreviations -- Chapter 2 Alveolar Epithelium in Lung Injury and Repair
2.1 Introduction -- 2.2 Alveolar Epithelial Cells during Development and Repair after Injury -- 2.2.1 Embryonic Lung Development-Branching Morphogenesis -- 2.2.2 Postnatal Alveolar Development -- 2.2.3 Alveolar Repair after Injury -- 2.3 Airway Epithelial Cells during Alveolar Repair after Injury -- 2.3.1 Airway Epithelial Cells Engaging in Airway Homeostasis and Repair -- 2.3.2 Airway Epithelial Cells Engaging in Alveolar Repair -- 2.3.3 Novel Distal Airway Cell Populations in Human Lungs -- 2.4 Emerging Mechanisms of Alveolar Epithelial Differentiation and Therapeutic Implications
2.4.1 The Integrated Stress Response and Mitochondrial Dysfunction -- 2.4.2 Wnt Signaling -- 2.4.3 Cell Senescence -- 2.4.4 Changes in the Extracellular Matrix and Biophysical Force: YAP/TAZ Signaling -- 2.4.5 Interactions with Mesenchymal Cells and Immune Cells -- 2.5 Conclusions -- Chapter 3 Environmental Toxicants in Lung Diseases -- 3.1 Introduction -- 3.2 Environmental Lung Diseases and Associated Pathologies -- 3.2.1 Lung Cancer -- 3.2.2 Asthma -- 3.2.3 Chronic Obstructive Pulmonary Disease -- 3.2.4 Interstitial Lung Disease -- 3.3 Environmental Toxicants: Sources and Modes of Action
3.3.1 Gaseous Phase -- 3.3.2 Volatile Organic Compounds -- 3.3.3 Respirable Particulate Matter -- 3.4 The Future of Environmental Toxicants in Lung Disease -- 3.4.1 Climate Changes -- 3.4.2 Regulation -- 3.5 Conclusions -- Abbreviations -- Chapter 4 Epigenetic Modifications of Histone in Lung Fibrosis -- 4.1 Introduction -- 4.1.1 Overview of Histone Acetylation -- 4.1.2 Overview of Histone Methylation -- 4.2 Environmental Causes of Histone Modifications -- 4.3 Histone Acetylation in Lung Fibrosis -- 4.3.1 HDACs -- 4.3.2 HATs and Histone Acetylation
Notes Description based upon print version of record
4.4 Histone Methylation and Other Histone Modification in Lung Fibrosis
Form Electronic book
ISBN 9781003833284
1003833284