| Description |
1 online resource |
| Contents |
Front Cover -- Cellular Senescence in Disease -- Cellular Senescence in Disease -- Copyright -- Contents -- Contributors -- Foreword -- REFERENCES -- 1 -- Fundamentals -- 1 -- Cellular senescence: from old to new testament -- Old testament-genesis of senescence -- New testament-from mechanisms and roles of senescence to therapies -- Replicative senescence and telomeres -- Oncogene-induced senescence and tumor suppression -- Damage-induced senescence -- Hallmarks of cellular senescence -- SASP -- Senescence in physiology, repair, and embryonic development -- Senescence in aging and age-related disorders -- Prosenescent and antisenescent therapies -- Clinical trials -- References -- 2 -- Cellular senescence in disease states -- 2 -- Premalignant lesions and cellular senescence -- Introduction -- Cellular senescence in premalignant lesions: evidence in various organs -- Skin -- Head and neck -- Lungs -- Gastrointestinal tract -- Liver -- Pancreas -- Mammary gland -- Prostate gland -- Cervix -- Thyroid -- Future perspectives -- References -- Further reading -- 3 -- Lung aging and senescence in health and disease -- Introduction -- Normal lung development and aging -- A brief introduction to COPD and IPF -- Abnormal hallmarks of lung aging in COPD and IPF -- Cellular senescence -- Mitochondrial dysfunction -- Stem cell dysfunction -- Telomere dysfunction -- Epigenetic changes and miRNAs -- Loss of protein homeostasis (proteostasis) -- Deregulated nutrient sensing -- Extracellular matrix (ECM) dysregulation -- Future treatment targeting lung senescence -- Conclusions -- Supported -- Abbreviations -- References -- 4 -- Cell senescence in pulmonary hypertension -- Introduction -- Pulmonary hypertension, a non-aging-related proliferative vascular disorder at the crossroads of vascular disease and cancer |
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General considerations about aging of the systemic and pulmonary vascular systems -- Considerations about constitutive cells of pulmonary vessels and the specificity of the pulmonary vasculature -- Potential mechanisms accounting for cell senescence in PH and PAH -- DNA damage is associated with PH -- Pulmonary artery smooth muscle cells (PASMCs) -- Pulmonary vascular endothelial cells (PECs) -- Genetic and environmental factors responsible for DNA damage in PAH -- The link between DNA damage, cell senescence, and PAH pathogenesis -- Alteration in the BMPR2/TGF beta pathway -- Hypoxia -- Drugs -- Telomere dysfunction -- Shear stress -- HIV infection -- Role for senescent cells in PH and PAH -- General considerations -- Induction of lung cell senescence: effect on PH -- Treatment with nutlin -- Telomerase inactivation -- Induction of cell senescence by activation of signaling pathways involved in chronic lung diseases -- Prevention or protection against lung cell senescence: effect on PH -- Inactivation of p53, p21, p16 -- Elimination of senescent cells in experimental PAH -- Conclusion -- References -- 5 -- Liver diseases fibrosis and cirrhosis -- Liver structure and function -- Cellular senescence -- Liver diseases-epidemiology and clinical aspects -- Senescence during aging of the healthy liver -- Senescence in acute liver injury -- Senescence in chronic liver disease -- Role of senescence in hepatic dysfunction -- Evolutionary role of senescence in the liver -- Senescence during hepatic carcinogenesis -- Summary and closing comments -- References -- 6 -- Cellular senescence during aging and chronic liver diseases: mechanisms and therapeutic opportunities -- Introduction -- Cellular senescence in the liver -- Mechanisms contributing to cellular senescence in liver -- Telomere dysfunction -- Autophagy impairment -- Mitochondrial dysfunction |
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Fatty acids -- Oxidative stress -- Telomere shortening -- Growth hormone axis -- mTOR activity -- Altered microbiome -- Threshold theory of senescent cell burden -- Implications of senescence in obesity: downstream effects -- Inflammation -- Inhibition of adipogenesis and ectopic lipid deposition -- NAD+ depletion due to CD38+ macrophage attraction -- Obesity-induced neurocognitive defects -- Paracrine effects on neighboring cells -- Promotion of cancer development -- Reduced regenerative potential -- Strategies to target obesity-related senescent cells -- Exercise and weight loss -- Senolytics -- SASP inhibitors or senomorphics -- Administration schedule of senescence-targeting therapies -- References -- 12 -- A framework for addressing senescent cell burden in the osteoarthritic knee: therapeutics, immune signaling, a ... -- Introduction -- Main -- Knee tissues degenerate in osteoarthritis -- Chronic presence of senescent cells in the knee accelerates osteoarthritic erosion -- Killing senescent cells in the knee can reduce OA-associated dysfunction -- Translating antisenescent therapies to the clinic for OA treatment -- Conclusion -- Competing interests -- References -- 13 -- Osteoporosis and bone loss -- Osteoporosis as a public health problem -- The hallmarks of aging in bone -- The role of cellular senescence in mediating age-related bone loss -- Identification of senescent cells in the bone microenvironment -- Causal role for cellular senescence in mediating age-related bone loss -- Role of cellular senescence in mediating age-related frailty -- Estrogen deficiency and cellular senescence -- The role of cellular senescence in the effects of diabetes mellitus on bone -- Cellular senescence and radiation- and chemotherapy-induced bone loss |
| Subject |
Pathology, Cellular.
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Age factors in disease.
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Cells -- Aging.
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Age Factors
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Cellular Senescence
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Age factors in disease
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Cells -- Aging
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Pathology, Cellular
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| Form |
Electronic book
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| Author |
Serrano, Manuel
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Muñoz-Espin, Daniel.
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| ISBN |
9780128225158 |
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0128225157 |
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