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Book Cover

Title Pediatric inflammatory bowel disease / Petar Mamula, Judith R. Kelsen, Andrew B. Grossman, Robert N. Baldassano, Jonathan E. Markowitz, editors
Edition 4th ed
Published Cham : Springer, 2023


Description 1 online resource (847 p.)
Contents Intro -- Foreword -- Preface -- Contents -- Contributors -- Part I: Etiology and Pathogenesis -- 1: Genetics of Inflammatory Bowel Diseases -- Introduction -- Genetic Epidemiology -- Ethnic and Racial Variations of Disease -- Family Studies -- Twin Studies -- NOD2 Gene and Crohn Disease -- Epidemiology of NOD2 Mutations -- Human Leukocyte Antigens in Ulcerative Colitis -- Genome-Wide Association Studies in IBD -- IL23R Polymorphisms in Crohn Disease and Ulcerative Colitis -- Association of the ATG16L1 Autophagy Gene with Crohn Disease -- Non-Coding Variation -- Meta-Analysis
GWAS Meta-Analysis in Ulcerative Colitis -- Association of TNFRSF6B and IL27 with Pediatric Age of Onset IBD -- Impact of the Immunochip -- Trans-ancestry Association Studies -- Next-Generation Sequencing -- Sequencing in High-Risk Individuals and Families -- Next-Generation Sequencing in Research -- Risk Prediction -- Genotype-Phenotype Correlations in Pediatric IBD -- Genetic Sharing Between Pediatric Age of Onset IBD and Other Autoimmune Diseases -- Summary -- References -- 2: Immunologic Regulation of Health and Inflammation in the Intestine -- Introduction
The Anatomy of the Intestinal Immune System -- The Intestinal Epithelium: Structure and Functional Subsets -- Epithelial Cell Function: Interlinked Connection with Microbiome and Dysfunction in IBD -- Gut-Associated Lymphoid Tissues -- Compartmentalized Gut Lymph Node Drainage -- Innate Immune Cell-Dependent Regulation of Intestinal Health -- Dendritic Cells -- Macrophages -- Granulocytes: Neutrophils, Eosinophils, Basophils, and Mast Cells -- Adaptive Immunity and Their Contribution to Intestinal Health and Inflammation -- T-cells -- B-cells
Essential Immunologic Pathways that Regulate Intestinal Health -- Innate Lymphoid Cell-Dependent Regulation of Intestinal Health -- Causes and Immunologic Drivers of Intestinal Inflammation in Humans -- Understanding Intestinal Immunity and IBD in Children -- Summary -- References -- 3: Cytokines and Inflammatory Bowel Disease -- Introduction -- Pro-Inflammatory Cytokines -- Tumor Necrosis Factor-Alpha -- Interferon-gamma -- Interleukin-1 -- Interleukin-2 -- Interleukin-6 -- Interleukin-12 -- Interleukin-17 -- Interleukin-23 -- Interleukin-18 -- Interleukin-13 -- Interleukin-33 -- Interleukin-37
Interleukin-9 -- Tumor Necrosis Factor-Like Ligand (Tl1a) -- Anti-Inflammatory Cytokines -- Transforming Growth Factor-Beta -- Interleukin-4 -- Interleukin-10 -- Interleukin-22 -- Summary -- References -- 4: The Gut Microbiota and Inflammatory Bowel Disease -- Introduction -- Characteristics of the Gut Microbiome -- Characteristics of the Gut Metabolome -- Diet and the Gut Microbiome -- Gut Microbiota-Host Interactions at the Mucosal Interface -- The Innate Immune System -- The Adaptive Immune System -- The Intestinal Epithelium -- IBD and the Human Gut Microbiome
Summary The latest edition of this essential text provides a comprehensive overview of the unique pediatric issues of inflammatory bowel disease. Through new and thoroughly revised chapters, the volume features updates on all aspects of etiology, diagnosis, and treatment, with an emphasis on recent understanding of pharmacokinetics and the utilization of cutting edge therapeutic monitoring to maximize efficacy of medical management. The new edition also highlights newer, recently approved drugs, emerging therapies, and the most recent recommendations regarding post-operative management for patients who ultimately require surgery. Written by experts in the field, Pediatric Inflammatory Bowel Disease, Fourth Edition is a valuable resource for both pediatric and adult gastroenterologists involved in the care of children with inflammatory bowel disease.
Notes Diet, IBD, and the Gut Microbiome
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerLink, viewed March 15, 2023)
Subject Inflammatory bowel diseases.
Pediatric gastroenterology.
Inflammatory Bowel Diseases
Inflammatory bowel diseases
Pediatric gastroenterology
Form Electronic book
Author Mamula, Petar.
Kelsen, Judith R
Grossman, Andrew B
Baldassano, Robert N.
Markowitz, Jonathan E.
ISBN 9783031147449