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Title IL-17, IL-22 and their producing cells : role in inflammation and autoimmunity / Valérie Quesniaux, Bernhard Ryffel, Franco Di Padova, editors
Edition 2nd ed
Published Basel ; New York : Springer, ©2013


Description 1 online resource (ix, 354 pages) : illustrations (some color)
Series Progress in Inflammation Research
PIR (Series)
Contents pt. I. Discovery and basic aspects of IL-17 -- IL-17A Family, Receptors, Proinflammatory Effects, and Production / Franco Di Padova, Bernhard Ryffel, Valerie Quesniaux -- IL-22 and IL-17: An Overview / Robert Sabat, Ellen Witte, Katrin Witte, Kerstin Wolk -- IL-17 Receptor Family: Structure, Signal Transduction, and Function / Fang Shen -- Contributions of IL-22 to TH17 Responses: Repairing and Protecting Peripheral Tissues / Jean-Christophe Renauld, Laure Dumoutier -- Central Role of Th17 Cells in Adaptive Immune Responses / Franco Di Padova, Bernhard Ryffel, Valerie Quesniaux -- Regulatory T cells Versus Th17: Differentiation of Th17 Versus Treg, Are They Mutually Exclusive? / Song Guo Zheng -- Other Sources of IL-17: iNKT Cells / Marie-Laure Michel, Maria C. Leite-de-Moraes -- Retinoic Acid in Mucosal Immune Regulation / Daniel Mucida, Hilde Cheroutre
pt. II. Experimental models of disease -- Critical Role of IL-17 in Experimental Arthritis / Marije I. Koenders, Wim B. van den Berg -- Dual Role of Th17 Cytokines, IL-17A, F, and IL-22 in Allergic Asthma / Bruno Schnyder, Silvia Schnyder-Candrian -- Inflammasome: IL-1/IL-17 Response in Lung Inflammation / Isabelle Couillin, Dieudonnée Togbe, Mamdouh Sedhom, Marc Le Bert, Hana Čipčić Paljetak, Francois Erard, René Moser, Bernhard Ryffel -- The Role of IL-17 in Experimental Autoimmune Myocarditis / Urs Eriksson -- Th17 Cells in Transplantation: Actors or Innocent Bystanders? / Louis-Marie Charbonnier, Benoit Vokaer, Philippe Lemaître, Dr. Alain Le Moine
pt. III. Role of IL-23-1L-17 in infection and tumor control -- Is IL-17 Required to Control Tuberculosis? / Andrea M. Cooper -- IL-17 and Mucosal Host Defense / Shabaana A. Khader, Jay K. Kolls -- Role of IL-17 and IL-17 Family Cytokines on Tumor Development / Frédérique Végran, Hélène Berger, Dr. Lionel Apetoh
pt. IV. IL-17 in clinical autoimmune disease -- IL-17 and Th17 Cells in Rheumatoid Arthritis and Other Inflammatory Conditions / Pierre Miossec -- Targeting Th17 Cells for Therapy of Multiple Sclerosis / Aaron J. Martin, Stephen D. Miller -- Involvement of Interleukin-17 Cytokines in Human Asthma / Anders Lindén -- IL17 and/or IL22 as Potential Target(s) for Crohn's Disease / Isabelle Wolowczuk, Benjamin Pariente, Matthieu Allez, Mathias Chamaillard -- Role of IL-23, IL-17, and IL-22 in Psoriasis / Robert Sabat, Kerstin Wolk -- Contribution of IL-22 to Experimental Skin Inflammation / Jean-Claude Lecron, Isabelle Paris, François-Xavier Bernard, Franck Morel
pt. V. Novel tools and therapeutic avenues -- Genetic Mouse Models to Investigate IL-17 Responses / Andrew L. Croxford, Thorsten Buch -- IL-17A as a Therapeutic Target for Autoimmune Diseases / Franco Di Padova, Jose Carballido
Summary The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Interleukins.
Interleukin-17 -- immunology
Immunity, Cellular -- physiology
Inflammation -- physiopathology
Interleukins -- immunology
MEDICAL -- Immunology.
Form Electronic book
Author Quesniaux, Valérie, editor
Ryffel, Bernhard, editor
Di Padova, Franco, editor
ISBN 9783034805223