| Description |
1 online resource (271 p.) |
| Series |
Oxidative Stress and Disease Ser. ; v.50 |
|
Oxidative Stress and Disease Ser
|
| Contents |
Cover -- Half Title -- Series Page -- Title Page -- Copyright Page -- Table of Contents -- Series Preface -- Preface -- Acknowledgements -- Editor -- Contributors -- Abbreviations -- 1 MOLECULAR MECHANISMS OF BRAIN INSULIN SIGNALING -- Interaction between Metabolism and Insulin -- Insulin and Insulin Growth Factor 1 Receptor -- Insulin Signaling Cascade in the Brain -- Downstream Signaling from the Insulin and Insulin Growth Factor 1 Receptor -- Insulin Signaling through the AKT Pathway -- Extracellular Signal-Regulated Protein Kinases Isoforms |
|
Negative Modulation of the Insulin Signaling Pathway -- Genetic Mutations Associated with Insulin Resistance -- Dephosphorylation of Proteins and Metabolites Involved in the Insulin Signaling Pathway -- Inhibitory Phosphorylations of Proteins in the Insulin Signaling Pathway -- Insulin and Insulin Growth Factor 1 Receptor -- IR Expression in the Brain -- Insulin Growth Factor 1 Receptor -- Insulin and Insulin Growth Factor 1 Receptor Heterodimers -- Insulin Receptor Substrate 1 Expression in the Brain -- Insulin Receptor Substrate 2 Expression in the Brain |
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Insulin Receptor Substrate 4 Expression in the Brain -- AKT Isoforms and Their Expression in the Brain -- Extracellular Signal-Regulated Protein Kinases Isoforms and Their Expression in the Brain -- Concluding Remarks -- Acknowledgments -- References -- 2 INSULI/IGF SIGNALING IN EARLY BRAIN DEVELOPMENT -- Effects on the Developing Central Nervous System -- First Steps in Central Nervous System Development: Neurulation -- Expanding Central Nervous System Cells: Neurogenesis -- Neuronal Survival and Development -- Cellular Differentiation -- Brain Region Specific Effects in Development |
|
The Cortex -- The Hippocampus -- The Hypothalamus -- Insulin Dependent Diseases and Brain Development Effects -- Gestational Diabetes and Decreased Maternal Insulin Sensitivity -- Malnutrition and Maternal Undernutrition -- Polycystic Ovarian Syndrome (PCOS) -- Concluding Remarks -- References -- 3 INSULIN SIGNALING MODULATES NEURONAL METABOLISM -- Introduction -- Overview of Neuronal Metabolism and Bioenergetics -- Insulin Regulates Neuronal Glucose Metabolism -- Insulin Signaling and Astrocyte-Neuron Lactate Shuttling -- Insulin Signaling and Ketone Body Metabolism in Neurons |
|
Insulin and Glycogen Metabolism in Neurons -- Insulin and Lipid Metabolism in Neurons -- Insulin Signaling Contributes to Mitochondrial Function and Homeostasis in Neurons -- Insulin Signaling Regulates Mitochondrial Bioenergetic Capacity -- Insulin Signaling Regulates Mitochondrial Mass by Supporting Mitochondrial Biogenesis -- Insulin Signaling Modulates Mitochondrial Stress Response Network -- Potential Link between Impaired Insulin/IGF-1 Signaling and Mitochondrial Dysfunction in Neurodegenerative Diseases -- Insulin Signaling Contributes to Intracellular Ca[sup(2+)] Homeostasis in Neurons |
| Notes |
Description based upon print version of record |
|
Concluding Remarks |
| Form |
Electronic book
|
| ISBN |
9781000643183 |
|
1000643182 |
|
