| Description |
1 online resource (xii, 284 pages) : illustrations (some color) |
| Series |
Cancer drug discovery and development |
|
Cancer drug discovery and development.
|
| Contents |
Epidemiology of IGF-1 and Cancer -- Aging and Cancer: The IGF-I Connection -- Obesity, Type 2 Diabetes and Cancer -- IGF System and Breast Cancer -- The Role of Insulin-Like Growth Factor Signaling in Prostate Cancer Development and Progression -- IGF-1 Cellular Action and its Relationship to Cancer: Evidence from in Vitro and in Vivo Studies -- Insulin-Like Growth Factor Signaling in Pediatric Sarcomas -- Cancer Genes, Tumor Suppressors, and Regulation of IGF1-R Gene Expression in Cancer -- Mouse Models of IGF-1R and Cancer -- Targeting the Insulin-Like Growth Factor-I Receptor in Cancer Therapy -- Targeting Insulin-Like Growth Factor Receptor 1 (IGF-1R) and Insulin Receptor Signaling by Tyrosine Kinase Inhibitors in Cancer -- Calories and Cancer: The Role of Insulin-Like Growth Factor-1 -- Cancer Cell Metabolism -- Overlaps Between the Insulin and IGF-I Receptor and Cancer |
| Summary |
The insulin-like growth factor system has been shown to play a critical role in cancer development and progression. Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, specifically brings these aspects to the reader. The volume covers the epidemiological aspects of the relationships between circulating insulin and IGF-1 levels and the risk for cancer and cancer-related mortality and in particularly in disease states such as obesity and Type 2 diabetes. It then addresses the basic biology of the system and how the ligands, receptors and IGF-binding proteins affect cancer cell biology and cancer progression. Finally, it discusses the therapeutic potential of inhibiting the receptors using various newly discovered monoclonal antibodies and tyrosine kinase inhibitors that are in preclinical and clinical trials |
| Analysis |
farmacologie |
|
pharmacology |
|
toxicologie |
|
toxicology |
|
biomedische wetenschappen |
|
biomedicine |
|
neoplasms |
|
Medicine (General) |
|
Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Tumors -- Growth.
|
|
Somatomedin.
|
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Cancer -- Endocrine aspects.
|
|
Insulin-like growth factor-binding proteins.
|
|
Somatomedins
|
|
Insulin-Like Growth Factor Binding Proteins
|
|
Neoplasms
|
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HEALTH & FITNESS -- Diseases -- General.
|
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MEDICAL -- Clinical Medicine.
|
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MEDICAL -- Diseases.
|
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MEDICAL -- Evidence-Based Medicine.
|
|
MEDICAL -- Internal Medicine.
|
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Médecine.
|
|
Insulin-like growth factor-binding proteins
|
|
Cancer -- Endocrine aspects
|
|
Somatomedin
|
|
Tumors -- Growth
|
| Form |
Electronic book
|
| Author |
LeRoith, Derek, 1945-
|
| ISBN |
9781461405986 |
|
146140598X |
|
