| Description |
1 online resource (446 p.) |
| Contents |
Front Cover -- Insulin -- Copyright Page -- Contents -- List of contributors -- Foreword -- Preface -- 1 Normal physiology: insulin secretion and insulin action -- 1 Insulin biosynthesis and release in health and disease -- Insulin biosynthesis -- The insulin gene-comparative physiology -- Transcriptional regulation of insulin gene expression -- Metabolic regulation of insulin gene expression -- Regulation of preproinsulin transcript stability -- Regulation of translation of the preproinsulin transcript -- Regulation of the processing of the preproinsulin peptide -- Insulin release |
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Concluding remarks -- References -- 2 Classic metabolic actions of insulin in humans: from physiology to disease and novel pharmacotherapeutics -- Introduction -- Insulin structure and synthesis -- Physiological actions of action -- Insulin transport and the insulin receptor -- Cellular insulin signaling -- Metabolic actions of insulin in classic target tissues -- Carbohydrate metabolism -- Lipid metabolism -- Protein metabolism -- Insulin dose-response considerations -- Carbohydrate metabolism -- Regulation of the postabsorptive metabolic state |
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Response to oral glucose ingestion or mixed meals -- Lipid metabolism -- Fasting state -- Postprandial state -- Nonclassic roles of adipocytes: implications for insulin action and cardiometabolic disease -- Brown adipose tissue -- Amino acid and protein metabolism -- Clinical states of acute metabolic decompensation associated with insulin deficiency -- Diabetic ketoacidosis -- Hyperglycemic hyperosmolar state -- References -- 3 Nonclassic effects of insulin: physiological actions on the vascular tissues and pathophysiological contributions to athe... -- Introduction |
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Overview of insulin and cardiovascular disease -- Effects of insulin on the vascular tissues and atherogenesis -- Insulin receptor structure and signaling in vascular cells -- Effects on insulin on blood flow and the vascular wall -- Effects on endothelial cells and selective insulin resistance -- Effects on vascular smooth muscle cells -- Effects on mitogenesis, basement membrane thickening, and extracellular matrix expansion -- Effects on thrombosis -- Summary -- Acknowledgments -- References -- 2 Role of insulin in human disease |
| Notes |
Description based upon print version of record |
|
Epidemiology and environmental triggers of type 1 diabetes |
| Form |
Electronic book
|
| ISBN |
9780323985697 |
|
0323985696 |
|
