Title Genetic control of malaria and dengue / edited by Zach N. Adelman

Published London : Academic Press is an imprint of Elsevier, [2015] ©2016

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Description 1 online resource Contents Front Cover -- Genetic Control of Malaria and Dengue -- Copyright Page -- Contents -- List of Contributors -- Biography -- Chapter 1 -- Chapter 2 -- Chapter 3 -- Chapter 4 -- Chapter 5 -- Chapter 6 -- Chapter 7 -- Chapters 8, 13 -- Chapter 9 -- Chapter 10 -- Chapter 11 -- Chapter 12 -- Chapter 14 -- Chapter 15 -- Chapter 16 -- Chapter 17 -- Chapter 18 -- Chapter 19 -- 1 Transgenic Pests and Human Health: A Short Overview of Social, Cultural, and Scientific Considerations -- Introduction -- Current State of GMOs -- Dengue Fever and Malaria -- Dengue Fever -- Malaria -- Dengue and Malaria Control -- Things to Consider Before Implementing GMO Control Methods -- Allocating Resources Between Treatment and Control -- Economic Development -- Community Engagement -- Values and Ethics of Control Measures -- Stewardship -- Animal Welfare -- Justice As Fairness -- Precaution -- An Ethical, Cultural, and Social Framework -- Regulation, Deliberation, and Public Communication of Biotechnology -- Current US Regulation of Biotechnology -- Biotechnology and the Public Sphere -- Models of Public Communication -- Public Opinion of Transgenics -- Conclusions -- Acknowledgments -- References -- 2 Concept and History of Genetic Control -- Introduction -- Agricultural Applications of Genetic Control Lead the Field -- Eradication of the New World Screwworm Fly Cochliomyia hominivorax Using the Sterile Insect Technique -- Use of Genetic Sexing Strains in Mediterranean Fruit Fly SIT Programs -- The Australian Sheep Blowfly (Lucilia cuprina) Field Female Killing Strains -- The Current State of Using SIT to Control Agricultural Pests -- Attempts to Extend Genetic Control to Mosquitoes -- Progress Without Modern Biotechnology -- Cytoplasmic Incompatibility and Wolbachia Population Replacement -- Classical SIT -- Chromosome Rearrangements Population Replacement Without Transgenesis -- Modern Biotechnology Attempts to Cover the Achilles Heel of Mosquito SIT -- Increasing Suppression Leveraging Larval Competition -- Paratransgenesis Using Transgenic Symbionts -- Population Replacement with Factors Detrimental to Mosquitoes -- Population Replacement with Beneficial Factors -- Acknowledgments -- References -- 3 Considerations for Disrupting Malaria Transmission in Africa Using Genetically Modified Mosquitoes, Ecology of Anopheline... -- Malaria in Africa: Current Situation -- Malaria Vectors in the African Region -- Malaria Parasites and Their Public Health Significance -- Current Approaches for Malaria Vector Control -- Biological and Ecological Considerations for GM Release and Monitoring -- Operational Considerations and Capacity Building in Africa -- References -- 4 Ecology of Malaria Vectors and Current (Nongenetic) Methods of Control in the Asia Region -- Malaria Risk in the South East Asia Region -- Ecology of Common Malaria Vectors -- Anopheles culicifacies -- Anopheles fluviatilis -- Anopheles stephensi -- Anopheles dirus -- Anopheles minimus -- Current (Nongenetic) Methods of Vector Control -- Indoor Residual Spraying -- Long-Lasting Insecticide-Treated Nets -- Source Reduction -- Integrated Vector Management -- Progress of (Nongenetic) Vector Control in the Asia Region -- Evidence of Success -- Evidence of Resistance to Insecticides -- Key Challenges -- Insecticide Resistance Monitoring -- Outdoor Biting -- Behavioral Changes of Vectors -- Conclusions -- References -- 5 Ecology of Anopheles darlingi, the Primary Malaria Vector in the Americas and Current Nongenetic Methods of Vector Control -- Introduction -- Ecology of Anopheles darlingi -- Larvae -- Adult Behavior -- Anopheles albimanus and Anopheles aquasalis: Regionally Important Vectors -- Colonization Coevolution of Anopheles and Plasmodium -- Current Control of Anopheles darlingi -- Adult Stage -- Larval Stage -- Scenarios Post Local Elimination of Anopheles darlingi -- Conclusions -- Acknowledgments -- References -- 6 Considerations for Disrupting Dengue Virus Transmission -- Ecology of Aedes aegypti and Current (Nongenetic) Methods of Control -- Current Burden of Dengue -- Causes of Widespread Dengue Transmission -- Major Dengue Vectors Worldwide -- How Does the Ecology of Aedes aegypti Complicate Control Efforts? -- Domestication -- Density-Dependent Population Regulation -- Spatial Heterogeneity and Super-Producer Aquatic Habitats of Aedes aegypti -- Cryptic Aquatic Habitats -- Egg Quiescence -- Population Dynamics of Aedes aegypti and Dengue -- Main Current Limitations to Control Dengue -- Current Interventions to Control Mosquito Vectors -- Improving Mosquito Control -- Local Aedes Populations Should be Managed in Space and Time Using an Area-Wide Approach -- Effective Control Agent -- Efficient Delivery System of the Control Agent -- Sufficient Coverage -- Evaluation of Impact -- Perspectives of Success Using Genetically Modified Mosquitoes to Control Dengue Vectors -- Self-Limiting Population Suppression -- Self-Sustaining Vector Population Replacement -- References -- 7 The Challenge of Disrupting Vectorial Capacity -- Purpose -- Strategy: How Do We Use the Vector to Achieve Reductions in Parasite Transmission? -- Lessons Learnt? -- Effective Delivery -- Maintenance of the Quality of the Intervention -- Sustaining Effective Delivery -- Polyvalent Intervention -- GM Interventions: How Do We Manage the Expectations and Measure Impact -- Managing Expectation -- Measuring Impact -- References -- 8 Gene Insertion and Deletion in Mosquitoes -- Random Insertion of Genetic Elements -- Transposons -- Docking-Site-Based Integration Other Recombinases -- Site-Specific Nucleases -- Homing Endonucleases -- Chimeric Nucleases (ZFNs and TALENs) -- CRISPR/Cas9 -- Targeted Insertion of Genetic Elements Through Homologous Recombination -- Controlling Transgene Expression -- the Current State of the Mosquito Toolbox -- Promoters -- Identifying New Promoters, a Cautionary Tale -- Bipartite Tet Systems -- Other Bipartite Expression Systems -- Considerations and Outlook -- References -- 9 Gene Drive Strategies for Population Replacement -- Introduction -- Early Inspiration -- Promising New Systems -- Design Criteria -- Gene Drive Systems That Spread Via Target Site Cleavage and Repair -- Transposable Elements -- Homing Endonuclease Genes -- TALENs and ZFNs -- Clustered, Regularly Interspaced, Short Palindromic Repeats -- Toxin-Antidote Gene Drive Systems -- Medea -- Toxin-Antidote-Based Underdominance -- Killer-Rescue -- Other Confineable Toxin-Antidote Systems -- Translocations -- Conclusion -- Gene Drive for Any Situation -- Outstanding Issues and Future Outlook -- Acknowledgments -- References -- 10 Exploring the Sex-Determination Pathway for Control of Mosquito-Borne Infectious Diseases -- Introduction -- Current Genetic Methods and Strategies -- Sterile Insect Technique -- Incompatible Insect Technique -- Release of Insects Carrying a Dominant Lethal Gene -- A Sex Ratio Distorter in Aedes aegypti and a Synthetic Sex Ratio Distorter in Anopheles gambiae -- Sex Separation -- Self-Sustaining Population Replacement Strategies -- Sex Determination in Mosquitoes -- M Locus and the Y Chromosome -- Doublesex (dsx), Fruitless (fru), and the Elusive Transformer (tra) -- Dosage Compensation and Sex Determination -- Toward the Discovery of the M Factor and Tra -- Ways and Considerations to Explore the Sex-Determination Pathway for Control -- Targets and Sex-Specific Reagents Sex Conversion Versus Female Lethality -- Timing of the Transgene Effect -- Conditional Expression -- "Driving Maleness" to Control Mosquito-Borne Infectious Diseases -- Acknowledgments -- References -- 11 Disruption of Mosquito Olfaction -- Introduction -- Anatomy of the Mosquito Olfactory System -- Chemosensory Receptors Detecting Odorants and CO2 in Drosophila and Mosquitoes -- Odorant Receptors -- Ionotropic Receptors -- Gustatory Receptors -- Use of Genome-Editing Technology to Decode Mosquito Attraction to Humans -- Targeted Mutagenesis of OR-Mediated Odorant Reception -- Targeted Mutagenesis of CO2 Reception -- Proposed Genetic Strategies Targeting Mosquito Olfaction -- Next-Generation Chemical Strategies Targeting Mosquito Olfaction -- Conclusions -- Acknowledgments -- References -- 12 Disruption of Mosquito Blood Meal Protein Metabolism -- Introduction: An Overview of Blood Meal Protein Metabolism in Mosquitoes -- Exploring Blood Meal Protein Amino Acid Carbon Skeletons Using Radioactive Isotopes -- Dynamics of Blood Meal Protein Amino Acid Metabolism -- Fate of Blood Meal Amino Acids at the End of the Gonotrophic Cycle and Utilization of Maternal Energy Reserves During a Gon... -- Investigating Blood Meal Protein Amino Acid Nitrogen Using Traditional and Modern Approaches -- Fate of Nitrogen Derived from Deamination of Amino Acids Using Classical Biochemical and Molecular Techniques -- Fate of Nitrogen Derived from Deamination of Amino Acids Using Isotopically-Labeled 15N-Compounds, Mass Spectrometry, and R... -- Fixation and Assimilation of Ammonia -- Excretion of Nitrogen Waste Products -- Conclusions and Future Directions -- Acknowledgments -- References -- 13 Engineering Pathogen Resistance in Mosquitoes -- Malaria and Dengue -- Malaria -- Dengue -- Engineering Resistance to Pathogens -- Pathogen-Derived Resistance (RNAi) Notes Includes index Online resource; title from PDF title page (ScienceDirect, viewed October 28, 2015) Subject Mosquitoes as carriers of disease. Malaria -- Prevention. Dengue -- Prevention Genetic engineering. Mosquitoes. Malaria. Dengue. Insects as carriers of disease. Arbovirus infections. Protozoan diseases. Arthropod vectors. Diptera. Hemorrhagic fever. Parasitic diseases. Insects. Virus diseases. Diseases. Arthropoda. Communicable diseases -- Transmission. Public health. Medical care. Culicidae Malaria Dengue Insect Vectors Arbovirus Infections Protozoan Infections Arthropod Vectors Flavivirus Infections Diptera Hemorrhagic Fevers, Viral Flaviviridae Infections Disease Vectors Parasitic Diseases Insecta Virus Diseases RNA Virus Infections Disease Arthropods Disease Transmission, Infectious Public Health Invertebrates Environment and Public Health Animals Delivery of Health Care Eukaryota Organisms Patient Care disease. illness. public health. Insecta (class) SCIENCE -- Life Sciences -- Anatomy & Physiology. Virus diseases Public health Protozoan diseases Parasitic diseases Mosquitoes Medical care Malaria Insects as carriers of disease Insects Hemorrhagic fever Diseases Diptera Dengue Communicable diseases -- Transmission Arthropoda Arthropod vectors Arbovirus infections Dengue -- Prevention Genetic engineering Malaria -- Prevention Mosquitoes as carriers of disease Form Electronic book Author Adelman, Zach N., editor ISBN 9780128004050 0128004053

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