| Description |
1 online resource (xv, 486 pages) : illustrations (some color) |
| Contents |
Foreword: Contemporary Liver Immunology and Immunopathology: Obstacles and Opportunities / Ian R. Mackay -- Part I: Introduction. A Short Primer on Fundamental Immunology / Cliona O'Farrelly and Derek G. Doherty ; Role and Function of Liver Sinusoidal Endothelial Cells / Percy A. Knolle ; Innate Immune Mechanisms in the Liver / Cliona O'Farrelly and Derek G. Doherty ; Antigen Processing and Presentation in the Liver / Masanori Abe and Angus W. Thomson ; Adaptive Immunity in the Liver / James D. Gorham ; Hepatic NK, NKT, and T Cells / Golo Ahlenstiel and Barbara Rehermann ; Cytokines in Liver Health and Disease / Pietro Invernizzi, Ilaria Bianchi, Massimo Locati, Raffaella Bonecchi, and Carlo Selmi ; Prevalence and Significance of Autoantibodies in Acute and Chronic Liver Diseases and Hepatocellular Carcinoma / Christian P. Strassburg and Michael P. Manns ; The Role of Inflammation and Immunity in the Pathogenesis of Liver Fibrosis / Wajahat Z. Mehal and Scott L. Friedman ; Clinical Use of Immunopathology Techniques in Liver Diseases / Chen Liu and James M. Crawford ; Tumor Immunology: Hepatocellular Carcinoma, Cholangiocarcinoma, and Metastatic Neoplasms / Christopher L. Bowlus -- Part II: Bacterial, Parasitic, and Viral Infections of the Liver. Innate and Adaptive Immune Responses to Bacterial and Parasite Infections: Clinicopathological Consequences / Valentina Medici, Lorenzo Rossaro, Sripriya Balasubramanian, and Stuart H. Cohen ; Immune Response to Hepatitis A and E Viruses: Role in Disease Pathogenesis and Viral Elimination / Johannes Hadem and Michael P. Manns ; Role of the Immune Response in Hepatitis B: Determinants of Severity, Chronicity, and Response to Antiviral Therapy / Antonio Bertoletti, Patrick Kennedy, and Adam J. Gehring ; Immune Responses in Acute and Chronic Hepatitis C: Implications for Prognosis and Therapy / Heiner Wedemeyer, Markus Cornberg, and Michael P. Manns ; Immunopathogenesis of Extrahepatic Manifestations in HAV, HBV, and HCV Infections: Importance of Recognition and Therapy / Sven Pischke, Arndt Vogel, Elmar Jaeckel, and Michael P. Manns -- Part III. Autoimmune Liver Diseases. Immunogenetics of Autoimmune Liver Disease: Risk Factors for Susceptibility and Progression / Peter Tickell Donaldson ; Primary Biliary Cirrhosis and Autoimmune Cholangitis / Carlo Selmi, Ana Lleo, Pietro Invernizzi, and M. Eric Gershwin ; Sclerosing Cholangitis: Primary and Secondary / Sue Cullen and Roger Chapman ; Autoimmune Hepatitis / Diego Vergani and Giorgina Mieli-Vergani ; Unique Aspects of Autoimmune Hepatitis in Children / Giorgina Mieli-Vergani and Diego Vergani ; Overlap Syndromes of Autoimmune Hepatitis With Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis / Ulrich Beuers and Christian Rust ; Animal Models of Autoimmune Liver Diseases / Markus Biburger and Gisa Tiegs -- Part IV: Alcoholic and Nonalcoholic Fatty Liver Diseases. The Immune Response in the Pathogenesis of Alcoholic Liver Disease / Lynell W. Klassen and Geoffrey M. Thiele ; Immunomodulation Therapy for Alcoholic Hepatitis: Rationale and Efficacy / Robert O'Shea and Arthur J. McCullough ; Role of Immune Response in Nonalcoholic Fatty Liver Disease: Evidence in Human and Animal Studies / Liu Yang and Anna Mae Diehl -- Part V: Acute Liver Failure. Mechanisms of Acute Liver Failure / Christian Trautwein and Alexander Koch -- Part VI: Hepatotoxicity of Medications. Immune Mechanisms in Drug-Induced Hepatotoxicity: Therapeutic Implications / Zhang-Xu Liu and Neil Kaplowitz ; Acute and Chronic Liver Diseases Induced by Drugs or Xenobiotics / Frank N.A.M. van Pelt, Michelle A. Carey, and John B. Carey -- Part VII: Transplantation. Clinical Use of Immunosuppressive Drugs to Control the Immune Response / John M. Vierling ; Hepatic Complications of Hematopoietic Cell Transplantation / Howard M. Shulman and George B. McDonald ; Acute and Chronic Rejection of the Liver Allograft / James Neuberger ; Immunological Tolerance in Allo- and Xenografts / Aftab A. Ansari and Kovit Pattanapanyasat ; Autoimmune Diseases in Transplanted Livers / Hiromi Ishibashi, Shinji Shimoda, Minoru Nakamura, and M. Eric Gershwin ; Immunopathogenesis and Outcomes of Recurrent Hepatitis C / James R. Burton, Jr., Lucy Golden-Mason, and Hugo R. Rosen |
| Summary |
Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, allograft rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has various applications in several disciplines of science, and as such is further divided. Liver Immunology: Principles and Practice covers bacterial, parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and nonalcoholic fatty liver diseases, and transplantation in an easy-to-read and thorough format. Authors also address the key issues that have arisen in this field in recent years, including physiological roles of hepatocytes, sinusoidal lining cells, activated macrophages (Kupffer cells), cholangiocytes and stellate cells, and their modulation of T cells, natural killer (NK) cells and NKT cells. This volume will become a must-read for clinicians, investigators and students, novice and expert alike |
| Bibliography |
Includes bibliographical references and index |
| In |
Springer eBooks |
| Subject |
Liver -- Diseases -- Immunological aspects
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Liver -- Immunology
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Liver -- immunology
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Liver -- pathology
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Autoimmunity -- immunology
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Liver Diseases -- immunology
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MEDICAL -- Hepatology.
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Liver -- Immunology.
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Liver -- pathology.
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Autoimmunity -- immunology.
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Liver diseases -- Immunology.
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Liver -- Diseases -- Immunological aspects.
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Liver -- Diseases -- Immunological aspects
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Liver -- Immunology
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| Form |
Electronic book
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| Author |
Gershwin, M. Eric, 1946-
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Vierling, John M.
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Manns, Michael P. (Michael Peter)
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| LC no. |
2006038697 |
| ISBN |
9781588298188 |
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1588298183 |
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9781597455183 |
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1597455180 |
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1281136921 |
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9781281136923 |
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