Title Immunology of nude mice / author, Miroslav Holub

Published Boca Raton, FL : CRC Press, 2019

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Description 1 online resource Series Routledge revivals Routledge revivals. Contents Intro -- Title Page -- Copyright Page -- Preface -- The Author -- Table of Contents -- Chapter 1 Introduction: The Contradictory Mouse -- Chapter 2 The Nude Mutation -- Chapter 3 The Thymic Defect -- I. Introduction -- II. The Derivation of the Epithelial Stroma -- III. Thymic Cysts and Brown Fat -- IV. The Mesenchymal Component -- V. The Essential Defect in the Nude Mouse Thymus -- VI. The Lymphatic Rudiment and the Lymphoid Infiltraton in the Polycystic Organ -- VII. The Thymus of the nu/ + Hybrid -- VIII. Thymic Hormones -- References -- Chapter 4 T Cells I. T-Cell Differentiation and Function -- II. The Specificity Pattern of T Cells -- III. Natural Killer and Cytotoxic Cells -- References -- Chapter 5 B Cells and Immunoglobulins -- I. Introduction -- II. B-Cell Turnover and Differentiation -- III. Antibody Formation -- IV. Tolerance -- V. Polyclonal Activators and Background Immunoglobulins -- References -- Chapter 6 Stem Cells and Connective Tissues -- I. Bone Marrow Stem Cell Potential and Leukocyte Numbers -- II. Connective Tissues -- III. Mast Cells -- References -- Chapter 7 Phagocytic System and Native Resistance I. Phagocytic Cells in Ontogeny -- II. Phagocytic Cells in Adult Nude Mice -- References -- Chapter 8 Lymphatic Tissues and Cellular Immune Reactions -- I. Lymphatic Tissues -- II. Cell-Mediated Immune Reactions -- References -- Chapter 9 Hairlessness and Metabolic Compensations -- I. The Skin -- II. Metabolic Rates and Deviations -- References -- Chapter 10 Neuronendocrine Regulations -- I. Endocrine Organs and Functions -- II. Thermogenesis and Neurotransmitters -- III. Central Nervous System and Behavior -- References -- Chapter 11 Nude Gene Transfers and Remutation -- Chapter 12 Conclusions Summary First published in 1989, Immunology of Nude Mice presents a discussion of the nature of this viable laboratory mutant. This new volume updates all immunological information contained in the sparse literature concerning nude mice. It comprehensively explores some of the fre-quent questions associated with nude mice, such as if the mutant is really athymic or if the thymic defect causes all of the other deviations from brain to gonads. The practical consequences of hairlessness of the mutant are also consid-ered. Illustrated with original photographs and tables doc-umenting novel facts in immunology and physiology of nude mice, this publication is valuable for investigators and stu-dents entering the field Bibliography Includes bibliographical references Notes Miroslav Holub, M.D., Ph. D., is a senior scientific worker at the Institute for Clinical and Experimental Medicine in Prague, Czechoslovakia. He heads the experimental unit of the Institute's Immunological Department. Dr. Holub graduated and received the M.D. degree from the Charles IV. University, Prague, in 1953 and worked as a clinical pathologist. In 1954, he joined the newly formed immunological laboratory in the Biological (later Microbiological) Institute of the Czechoslovak Academy of Sciences and obtained the scientific degree, about equivalent to Ph. D. in 1958. He was engaged in the studies of cytological aspects of antibody formation and of the key role of the lymphocyte. During 1965 to 1967, he worked in the immunological laboratory of the Public Health Research Institute of New York City and in 1968 to 1969 at the Max Planck Institute for Immunobiology in Freiburg, W. Germany. He was introduced to the nude mouse club by the late Dr. Berenice Kindred, and has stayed on as a faithful member for all years thereafter, with the main interest focused on the nature of thymic dysgenesis. In 1972, he was transferred from the Academy to the Institute for Clinical and Experimental Medicine. He has published, so far, 130 scientific papers in immunology, one monograph (Structure of the Immune System, Prague 1979) and chapters in the Modern Trends in Immunology 2, London 1967 and in the Grundriss der Immunbiologie, Leipzig 1978 and 1988. During 1968 to 1970 Dr. Holub was a member of the presidium of the Union of Czechoslovak Scientific Workers. He is also a known writer translated in most European countries, the U.S., India, China, and Japan. In 1985, he obtained an honorary degree from Oberlin College, Oberlin, Ohio, and is a member of the Bavarian Academy of Arts Subject Nude mouse -- Immunology Immunology -- Animal models. HEALTH & FITNESS -- Herbal Medications. MEDICAL -- Research. Immunology -- Animal models Form Electronic book ISBN 9780429281792 042928179X 9781000085471 1000085473 9781000086973 1000086976 9781000083484 1000083489

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