Title Radiopharmaceutical chemistry / Jason S. Lewis, Albert D. Windhorst, Brian M. Zeglis, editors

Published Cham, Switzerland : Springer, [2019]

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Description 1 online resource Contents Why Nuclear Imaging and Radiotherapy -- A Short History of Nuclear Medicine -- The Basics of Nuclear Chemistry and Radiochemistry: and Introduction to Nuclear Transformations and Radioactive Emissions -- Methods for the Production of Radionuclidies for Medicine -- An Overview of Targeted Radiotherapy -- An Overview of Nuclear Imaging -- Small Molecules as Radiopharmaceutical Vectors -- Peptides as Radiopharmaceutical Vectors -- Immunoglobulins as Radiopharmaceutical Vectors -- Nanoparticals as Radiopharmaceutical Vectors -- The Radiopharmaceutical Chemistry of Carbon-11: Basic Principles -- The Radiopharmaceutical Chemistry of Carbon-11: Tracers and Applications -- The Radiopharmaceutical Chemistry of Nitrogen-13 and Oxygen-15 -- The Radiopharmaceutical Chemistry of the Radionuclides of Gallium and Indium -- The Radiopharmaceutical Chemistry of Fluorine-18: Nucleophilic Fluoriantions -- The Radiopharmaceutical Chemistry of Fluorine-18: Electrophilic Fluorinations -- The Radiopharmaceutical Chemistry of Fluroine-18: Next-Generation Fluorinations -- The Radiopharmaceutical Chemistry of Technetium-99m -- The Radiopharmaceutical Chemistry of the Radioisotopes of Copper -- The Radiopharmaceutical Chemistry of the Radioisotopes of Lutetium and Yttrium -- The Radiopharmaceutical Chemistry of Zirconium-89 -- The Radiopharmaceutical Chemistry of the Radioisotopes of Iodine -- The Radiopharmaceutical Chemistry of Alpha-Emitting Radionuclides -- The Radiopharmaceutical Chemistry of Seldom-Used Radionuclides in Nuclear Medicine -- Bioconjugation Methods for Radiopharmacutical Chemistry -- Click Chemistry in Radiophamaceutical Chemistry -- Equipment and Instrumentation for Radiopharmaceutical Chemistry -- Kinetic Modeling and Radiotracers -- An introduction to Radiation Protection -- An Introduction to Biostatistics -- Choosing a Target for Nuclear Imaging or Targeted Radiotherapy -- Target Identification, Lead Discovery, and Optimization -- Preclinical Experimentation in Oncology -- Preclinical Experimentation in Neurology -- The Clinical Translation Process in Europe -- The Clincial Translation process ion the United States -- Setting up a Successful Radiopharmaceutical Production Facility 880-01 Intro; Foreword; Preface; Contents; Editors and Contributors; Part I: First Principles; Why Nuclear Imaging and Radiotherapy?; Fundamentals; What Is Nuclear Medicine?; Why Nuclear Imaging?; Why Nuclear Radiotherapy?; Why Nuclear Medicine Vis-a-Vis Alternatives?; Details; Clinical Applications for Nuclear Imaging; Clinical Applications of Nuclear Radiotherapy; Tricks of the Trade; What Tools Do We Need?; Controversial Issues; Will Other Imaging and Therapeutic Approaches Replace Nuclear Approaches?; The Future; What Does the Future of Nuclear Medicine Look Like?; The Bottom Line; References 880-01/(S The Basics of Nuclear Chemistry and Radiochemistry: An Introduction to Nuclear Transformations and Radioactive EmissionsProcesses of Transformations: Overview; Composition and Mass of an Atomic Nucleus; Mass and Mass Defect; Binding Energy; Models; From Stable to Unstable Nuclei; Transformation, non "Decay"; β-Transformations; Three Pathways: β--Process, β+-Process, and Electron Capture (ε); Quarks: The Elementary Particles Behind the Nucleons; Energetics of β-Transformations: Values of ΔE and Q; Kinetic Energetics of β-Transformation Products; Quantum Theory of β-Transformation Phenomena A Short History of Nuclear MedicineThe Discovery of Radiation and Radioactivity; The Discovery of the Neutron; The Discovery of Artificial Radioactivity and the Tracer Principle; The Discovery and Use of the Radionuclides of Iodine; Early Studies with Radionuclides of Carbon; Post-World War II Nuclear Medicine; The 99Mo/99mTc Generator and 99mTc-Labeled Radiopharmaceuticals; Development of Imaging Instrumentation; The Production of Radionuclides; The Discovery and Applications of FDG; The Bottom Line; References Summary This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry, heavy element radiochemistry, or solely on the clinical applications of radiopharmaceuticals. This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic. The first section is a general overview covering fundamental and broad issues like "The Production of Radionuclides" and "Basics of Radiochemistry". The second section is the main focus of the book. In this section, each chapter's author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a "Best of the Rest" chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including "Bioconjugation Methods," "Click Chemistry in Radiochemistry", and "Radiochemical Instrumentation."-- Provided by publisher Bibliography Includes bibliographical references and index Notes Extraction Online resource; title from digital title page (viewed on April 18, 2019) Subject Radiopharmaceuticals. Pharmaceutical chemistry. Radiopharmaceuticals Chemistry, Pharmaceutical Pharmaceutical chemistry Radiopharmaceuticals Form Electronic book Author Lewis, Jason (Jason S.), editor. Windhorst, Albert D., editor. Zeglis, Brian Matthew, editor. ISBN 3319989472 9783319989488 3319989480 9783319989471

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