Title Cell Adhesion and Communication Mediated by the CEA Family

Edition 1st ed Published Lisse : CRC Press, 1998 ©2005

Click on the following:
BIOSCIENCEnetBASE

Copies

Description 1 online resource (337 pages) Contents BOOK COVER -- HALF-TITLE -- TITLE -- COPYRIGHT -- CONTENTS -- PREFACE TO THE SERIES -- INTRODUCTION -- CONTRIBUTORS -- 1. THE NATURE AND EXPRESSION OF THEHUMAN CEA FAMILY -- CHROMOSOMAL LOCALIZATION OF THE CEA GENE FAMILY -- NUMBER OF GENES AND GENOME ORGANIZATION OF CEA FAMILY MEMBERS -- EXON-INTRON ORGANIZATION -- PSEUDOGENES -- EVOLUTION OF THE CEA GENE FAMILY -- STRUCTURE OF CEA FAMILY GLYCOPROTEINS -- Carcinoembryonic antigen (CEA) -- Nonspecific crossreacting antigen (NCA) -- Biliary glycoprotein (BGP) -- CEA gene family member 1 (CGM1) -- CEA gene family member 2 (CGM2) -- CEA gene family member 6 (CGM6) -- CEA gene family member 7 (CGM7) -- TRANSCRIPTIONAL REGULATION AND PROMOTER REGIONS -- TISSUE EXPRESSION OF CEA-SUBFAMILY MEMBERS -- Normal human tissues -- Human tumor tissues -- DETAILED ANALYSIS OF THE EXPRESSION OF CEA SUBFAMILY MEMBERS IN NORMAL ADULT COLON AT mRNA AND PROTEIN LEVELS -- Relationship to cellular differentiation of enterocytes -- Presence in "fuzzy coat" (glycocalyx) at apical surface of columnarepithelial cells -- Effect of cytokines on CEA, NCA50/90 and BGP synthesisand release -- POSSIBLE FUNCTIONS OF CEA SUBFAMILY MEMBERS IN NORMAL PHYSIOLOGY -- ACKNOWLEDGMENTS -- REFERENCES -- 2. THE NATURE AND EXPRESSION OF THE RODENT CEA FAMILIES: EVOLUTIONARY CONSIDERATIONS -- DISCOVERY AND NOMENCLATURE OF THE CARCINOEMBRYONIC ANTIGEN (CEA) FAMILY IN RODENTS -- THE MOUSE AND RAT CEA GENE FAMILIES -- Size of the mouse and rat CEA gene families -- Structural Features of Mouse and Rat CEA Family Members -- GENOMIC ORGANIZATION AND CHROMOSOMAL ARRANGEMENT OF THE MURINE CEA GENE FAMILY -- Genomic organization -- Chromosomal Arrangement of the Murine CEA Gene Cluster -- EVOLUTION OF THE CEA GENE FAMILIES -- EXPRESSION PATTERN OF THE RODENT CEA FAMILY -- CEA Subgroup -- Bgp1, C-CAM1 -- Bgp2 -- C-CAM4 -- Cea10 -- Cea5 -- PSG subgroup EVOLUTIONARY CONSIDERATIONS REGARDING THE FUNCTIONS OF THE CEA FAMILIES -- What Does Evolution Tell Us about the Function of the CEA Family? -- Bgp1, C-CAM1 -- Other Murine and Rat CEA Subgroup Members -- PSG -- CONCLUSIONS AND PERSPECTIVES -- REFERENCES -- 3. PROPERTIES OF ADHESION MEDIATED BY THE HUMAN CEA FAMILY -- INTRODUCTION -- MOLECULAR MECHANISMS INVOLVED IN INTERCELLULAR ADHESION -- CEA -- NCA -- BGP -- THE ROLE OF CARBOHYDRATE STRUCTURES -- OTHER LIGANDS -- CEA AS A "REPULSION MOLECULE"? -- CLINICAL SIGNIFICANCE -- ACKNOWLEDGEMENTS -- REFERENCES -- 4. CELL ADHESION AND SIGNALING BY THE RODENT CEA FAMILY -- INTRODUCTION -- CLONING AND MOLECULAR PROPERTIES OF C-CAM AND BGP -- TISSUE PREVALENCE AND SUBCELLULAR LOCATION -- EXPRESSION DURING EMBRYONIC DEVELOPMENT -- REGULATION OF EXPRESSION -- ADHESIVE PROPERTIES AND FUNCTION -- ADDITIONAL FUNCTIONS -- Ecto-ATPase -- Bile Acid Transporter -- Virus Receptor -- Growth Control -- SIGNALING -- Phosphorylation -- Binding Proteins -- Dimerization -- CONCLUSIONS -- ACKNOWLEDGEMENTS -- REFERENCES -- 5. CEA FAMILY MEMBERS EXPRESSED ON HEMATOPOIETIC CELLS AND THEIR POSSIBLE ROLE IN CELL ADHESION AND SIGNALING -- EXPRESSION OF MEMBERS OF THE CEA FAMILY ON CELLS OF THE HEMATOPOIETIC SYSTEM -- Myeloid cells -- Lymphocytic Cells -- ORGANIZATION OF THE CEA FAMILY MEMBERS ON HEMATOPOIETIC CELLS -- Multi-chain Immune Recognition Receptor (MIRR)-like Complex onGranulocytes -- GLYCOSYLATION OF CEA FAMILY MEMBERS ON HEMATOPOIETIC CELLS -- REGULATION AND MECHANISMS OF RELEASE OF THE CEA FAMILY MEMBERS -- FUNCTION OF CEA-FAMILY MEMBERS ON HAEMATOPOIETIC CELLS -- Adhesion -- Signal Transduction -- CD66 IN THE CLINIC -- CONCLUSION -- REFERENCES -- 6. SIGNAL TRANSDUCTION MEDIATED BY THE CEA FAMILY -- INTRODUCTION -- SIGNAL TRANSDUCTION IN GRANULOCYTES -- SIGNAL TRANSDUCTION IN CELL LINES AND TRANSFECTANTS MECHANISMS OF TRANSMEMBRANE SIGNALING MEDIATED VIA GPI-ANCHORED PROTEINS -- FUTURE DIRECTIONS -- REFERENCES -- 7. CONTRIBUTIONS OF THE HUMAN CEA FAMILY TO MALIGNANT TRANSFORMATION -- INTRODUCTION -- ARE THERE CHANGES IN CEA FAMILY EXPRESSION IN CANCER? -- A MODEL FOR CELLULAR TRANSFORMING EFFECTS OF CEA/NCA -- EFFECTS ON SINGLE CELL GROWTH PARAMETERS -- General Observations -- Quantitative Observations -- EFFECTS ON TERMINAL DIFFERENTIATION -- Myogenic Differentiation -- Adipogenic Differentiation -- Colonocyte Differentiation -- EFFECTS OF CEA/NCA ON TRANSFORMATION AND TUMORIGENICITY -- MOLECULAR MECHANISM FOR TRANSFORMING EFFECT OF CEA/NCA -- Requirement for GPI Membrane Linkage -- Requirements for External Domains -- Requirement for Signaling? -- EFFECTS OF CELLULAR CONTEXT -- IMPLICATIONS FOR NORMAL FUNCTION -- A Hypothesis -- Transgenic Studies -- Evolutionary Studies -- CLINICAL SIGNIFICANCE AND FUTURE DIRECTIONS -- ACKNOWLEDGEMENTS -- REFERENCES -- 8. ROLE OF C-CAM AS A TUMOR SUPPRESSOR -- INTRODUCTION -- NOMENCLATURE -- GENOMIC ORGANIZATION, ALLELIC VARIATION AND ALTERNATIVE SPLICING -- C-CAM EXPRESSION IN NORMAL TISSUES -- DOWN-REGULATION OF C-CAM IN TUMORS -- TRANSCRIPTIONAL MECHANISMS AFFECTING C-CAM DOWN-REGULATION -- C-CAM FUNCTIONS AS A TUMOR SUPPRESSOR -- "ALL THAT GLITTERS IS NOT GOLD" -- POSSIBLE MECHANISMS OF C-CAM-DEPENDENT TUMOR GROWTH INHIBITION -- Phosphorylation-dependent mechanisms -- Phosphorylation-independent mechanisms -- CLINICAL PERSPECTIVES AND FUTURE CHALLENGES -- ACKNOWLEDGEMENTS -- REFERENCES -- 9. RODENT CEA-RELATED GLYCOPROTEINS ARE RECEPTORS FOR MURINE CORONAVIRUSES -- CORONAVIRUSES -- IDENTIFICATION OF BGP1a AS A RECEPTOR FOR MURINE CORONAVIRUS MHV-A59 -- ALTERNATIVE MHV RECEPTORS -- Multiple Splice Variants of Bgp1a -- Allelic Bgp1b Glycoproteins -- Bgp2 Glycoproteins -- Mouse Brain PSG -- Rat C-CAM Anchorless BGP1a -- STRUCTURAL CONSIDERATIONS OF BGP INTERACTIONS WITH MHV SPIKE GLYCOPROTEINS -- Mutational Analysis of MHVR -- Effects of Soluble Receptors on Virions -- DETERMINANTS OF SUSCEPTIBILITY TO VIRUS INFECTION -- Localization of Receptor Expression -- Level of Receptor Expression -- Virus Strain -- Host Range Mutants of Virus -- CONCLUSIONS -- ACKNOWLEDGMENT -- REFERENCES -- 10. CEA AND METASTASIS: A FACILITATOR OF SITE-SPECIFIC METASTASIS -- INTRODUCTION -- THE CLINICAL DATA LINKING CEA PRODUCTION WITH VISCERAL METASTASIS -- The Use of Immunodeficient Mice to Study Neoplastic Progression ofHuman Colorectal Carcinoma -- CEA Expression in Patients is Associated with the Tumorigenicity and Metastatic Potential of Human Colorectal Carcinoma in Nude Mice -- The Possible Role of CEA as an Adhesion Molecule in Metastasis -- The Effect of Exogenous CEA on Experimental Metastasis -- CEA Pretreatment Enhances Survival of Colorectal Carcinoma CellsAfter Implantation -- Cell Trafficking Studies Underscore the Importance of OrganAnatomy In Hepatic Metastasis -- The Anatomy of the liver -- The Structure of the Hepatic Sinusoid -- The Interaction of Human Colorectal Carcinoma Cells with the Hepatic Sinusoid after Intrasplenic Injection -- Implications of the Early Sequence of Tumor Cell Implantation in theliver -- METABOLISM OF CARCINOEMBRYONIC ANTIGEN AND PRODUCTION OF CYTOKINES -- Circulatory Clearance -- Role of the liver -- Role of Kupffer Cells -- CEA Binding Sequence -- Kupffer Cell Binding Proteins -- Other Sites of Expression of the 80 kDa CEA Binding Protein -- Function of the Kupffer Cell CEA Binding Protein -- IN SUMMARY -- REFERENCES -- 11. CARCEVOEMBRYONIC ANTIGEN (CEA) AS A MODEL FOR IMMUNOTHERAPY USING RECOMBINANT VACCINES -- INTRODUCTION -- CEA Biology -- CEA as a Target for Active Specific Immunotherapy -- PRECLINICAL STUDIES Recombinant Vaccinia-CEA (rV-CEA) -- Recombinant CEA -- CEA Polynucleotide Immunization -- Anti-Idiotypic Antibodies -- CEA AS A TARGET FOR CANCER VACCINES: CLINICAL STUDIES -- rV-CEA -- Anti-Id Monoclonal Antibody -- Recombinant CEA (rCEA) -- Second Generation CEA Vaccine Strategies -- SUMMARY -- REFERENCES -- 12. NOVEL CLINICAL APPLICATIONS OF CEA IN CANCER IMAGING AND THERAPY WITH RADIOLABELED ANTIBODIES -- INTRODUCTION -- EARLY STUDIES OF ANTIBODY IMAGING -- CEA ANTIBODY IMAGING TODAY -- CANCER RADIOIMMUNOTHERAPY -- ADVERSE REACTIONS TO ANTI-CEA ANTIBODIES -- FUTURE PROSPECTS -- CONCLUDING REMARKS -- ACKNOWLEDGMENTS -- REFERENCES -- 13. MICE TRANSGENIC FOR THE CEA GENE AS A MODEL FOR CANCER IMMUNOTHERAPY AND ANTIBODY TARGETING STUDIES -- INTRODUCTION -- CEA Transgenic Mice -- Preparation -- Generation and Tissue Distribution -- Immune Response -- Tumor Model -- Expression of CEA by Transfected MC-38 Cells -- Growth in vivo -- Tumor Localization -- Vaccines -- OUTLOOK -- ACKNOWLEDGMENT -- REFERENCES -- 14. THE CEA GENE PROMOTER AS A DRIVER OF TUMOR-SPECIFIC GENE EXPRESSION FOR GENE THERAPY -- GENE THERAPY: AN ALTERNATIVE TO ANTIGEN-DIRECTED TUMOR THERAPY? -- THERAPEUTIC GENES -- POTENTIAL VECTORS FOR INTRODUCTION OF THERAPEUTIC GENES INTO SOLID TUMORS -- TUMOR SELECTIVE EXPRESSION OF THERAPEUTIC GENES -- THE CEA GENE PROMOTER -- IN VIVO TESTING OF THE CEA GENE PROMOTER -- GENE THERAPY TRIALS USING THE CEA GENE PROMOTER -- OPTIMIZATION OF THE CEA GENE PROMOTER FOR TUMOR-DIRECTED EXPRESSION -- PROBLEMS WITH CEA PROMOTER-DRIVEN GENE THERAPY AND SUGGESTIONS FOR IMPROVEMENT -- REFERENCES -- INDEX Summary 1. The Nature and Expression of the Human CEA Family 2. Cell Adhesion and Signalling by the Rodent CEA Family 3. Signal Transduction Mediated by the CEA Family 4. Role of C-CAM as a Tumor Suppressor 5. CEA and Metastasis: A Facilitator of Site-Specific Metastasis 6. The CEA Gene Promoter as a Driver of Tumor-Specific Gene Expression for Gene Therapy 7. Novel Clinical Applications of CEA in Cancer Imaging and Therapy with Radiolabelled Antibodies 8. Mice Transgenic for the CEA Gene as a Model for Cancer Immunotherapy and Antibody Targeting Studies Notes Publisher supplied metadata and other sources Subject CEA genes. Cell adhesion. Cell interaction. CEA genes Cell adhesion Cell interaction Form Electronic book ISBN 9780203304211 0203304217

  Permalink