Title Immunogenetics : methods and applications in clinical practice / edited by Frank T. Christiansen, Brian D. Tait

Published New York : Humana Press, ©2012

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Description 1 online resource (xvi, 689 pages) : illustrations (some color) Series Methods in molecular biology, 1940-6029 ; 882 Methods in molecular biology (Clifton, N.J.) ; v. 882. 1064-3745 Contents Major histocompatibility complex : a paradigm for studies of the human genome / Richard J.N. Allcock -- HLA typing by SSO and SSP methods / Heather Dunckley -- Methods for diagnostic HLA typing in disease association and drug hypersensitivity / Michael D. Varney, Alison S.L. Castley, Katri Haimila, and Päivi Saavalainen -- HLA typing using bead-based methods / Daniel Trajanoski and Samantha J. Fidler -- HLA Typing by Direct DNA Sequencing / Linda K. Smith -- Data analysis of HLA sequencing using assign-SBT v3.6+ from conexio / Carla Wirtz and David Sayer -- Simple methods for the detection of HLA-G variants in coding and non-coding regions / Holger Nückel, Erick C. Castelli, Philippe Moreau, Crista Ochsenfarth, Peter A. Horn, and Vera Rebmann -- Molecular typing of HLA-E / Nina Lauterbach, Christina E.M. Voorter, and Marcel G.J. Tilanus -- Molecular analysis of complement component C4 gene copy number / Alison S.L. Castley and O. Patricia Martinez -- Genotyping of single nucleotide polymorphisms by 5' nuclease allelic discrimination / Mari Malkki and Effie W. Petersdorf -- High resolution MICA genotyping by sequence-based typing (SBT) / Yizhou Zou and Peter Stastny -- Standard methods for the management of immunogenetic data / Pierre-Antoine Gourraud, Jill A. Hollenbach, Thomas Barnetche, Richard M. Single, and Steven J. Mack -- Analytical methods for immunogenetic population data / Steven J. Mack, Pierre-Antoine Gourraud, Richard M. Single, Glenys Thomson, and Jill A. Hollenbach -- Analytical methods for disease association studies with immunogenetic data / Jill A. Hollenbach, Steven J. Mack, Glenys Thomson, and Pierre-Antoine Gourraud -- Impact of HLA matching and HLA antibodies in organ transplantation : a collaborative transplant study view / Caner Süsal and Gerhard Opelz -- Screening for antibodies against MICA by luminex flow cytometry / Yizhou Zou and Peter Stastny -- HLA antibody detection and characterization by solid phase immunoassays : methods and pitfalls / Andrea A. Zachary, Renato M. Vega, Donna P. Lucas, and Mary S. Leffell -- Detection and characterisation of alloreactive T cells / Mandvi Bharadwaj, Nicole A. Mifsud, and James McCluskey -- Detection of allo-HLA cross-reactivity by virus-specific memory T-cell clones using single HLA-transfected K562 cells / Lloyd J. D'Orsogna, Ellen M.W. van der Meer-Prins, Yvonne M. Zoet, Dave L. Roelen, Ilias I.N. Doxiadis, and Frans H.J. Claas -- Separation and cryopreservation of lymphocytes from spleen and lymph node / Gabriella Tassone and Samantha J. Fidler -- Crossmatching by Complement-Dependent Lymphocytotoxicity / Samantha J. Fidler -- Lymphocyte crossmatch by flow cytometry for Kidney Transplantation / Jonathan Downing -- Overview of the killer cell immunoglobulin-like receptor system / Raja Rajalingam -- KIR typing by non-sequencing methods : polymerase-chain reaction with sequence-specific primers / David Ordóñez, Manuela Moraru, Natalia Gómez-Lozano, Elisa Cisneros, and Carlos Vilches -- Killer cell immunoglobulin-like receptors (KIR) typing by DNA sequencing / Lihua Hou, Minghua Chen, Noriko Steiner, Kanthi Kariyawasam, Jennifer Ng, and Carolyn K. Hurley -- Overview of methods required to evaluate donor NK cell alloreactivity for haploidentical haemopoietic stem cell transplantation / Andrea Velardi -- Detection of NK cell alloreactivity by flow cytometric CD107a assay / Dianne De Santis, Bree Foley, Campbell S. Witt, and Frank T. Christiansen -- Clinical production and therapeutic applications of alloreactive natural killer cells / David H. McKenna, Diane M. Kadidlo, Sarah Cooley, and Jeffrey S. Miller -- Minor histocompatibility antigen typing by DNA sequencing for clinical practice in hematopoietic stem-cell transplantation / Eric Spierings and Els Goulmy -- Donor registries and search strategies / Carolyn K. Hurley, Machteld Oudshoorn, and Michelle Setterholm -- Cytokine gene polymorphisms : methods of detection and biological significance / Gurvinder Kaur and Narinder Mehra -- IMGT® tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations : IMGT/V-QUEST and IMGT/HighV-QUEST for NGS / Eltaf Alamyar, Patrice Duroux, Marie-Paule Lefranc, and Véronique Giudicelli -- IMGT/DomainGapAlign : the IMGT® tool for the analysis of IG, TR, MH, IgSF, and MhSF domain amino acid polymorphism / François Ehrenmann and Marie-Paule Lefranc -- Human Gm, Km, and Am allotypes and their molecular characterization : a remarkable demonstration of polymorphism / Marie-Paule Lefranc and Gérard Lefranc Summary The HLA molecules are important regulators of the immune response through mediating antigen presentation and interaction between key immune mediating cells. They are also the major histocompatibilty barriers to transplantation, which is the clinical paradigm of the self versus non self concept. It is now recognized that this diverse range of gene systems involved in the control of the immune response have been shown to be important in many aspects of clinical practice. As a result many new molecular and cellular methods have been developed for identifying these genes and their polymorphisms, and immunogenetic laboratories specializing in these methods have developed to support transplantation and other clinical programs. Immunogenetics: Methods and Applications in Clinical Practice focuses on methods for human clinical practice. The emphasis rests on those assays which are of established or potential clinical utility and are likely to be included in the repertoire of tests provided by a routine diagnostic and service laboratory. This volume also contains several review chapters of the MHC complex, the KIR complex, the human immunoglobulin allotypes, as well as reviews of the methods for the detection of alloreactive NK cells and the detection of HLA antibodies by solid phase assays. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Immunogenetics: Methods and Applications in Clinical Practice seeks to serve both the immunogenetics community and the wider scientific community with a collection of detailed information and helpful tips attained by many years of experience in the field Analysis Medicine Human genetics Immunology Biomedicine biomedische wetenschappen immunologie humane genetica Medicine (General) Geneeskunde (algemeen) Bibliography Includes bibliographical references and index Notes English Online resource; title from PDF title page (Springer Protocols, viewed Oct. 12, 2012) Subject Immunogenetics -- Laboratory manuals Immune system. Biology. Transplantation immunology. Life sciences. Physical sciences. Immunogenetics. Histocompatibility. Methodology. Immunity. Investigative Techniques Immune System Phenomena Biology Publication Formats Transplantation Immunology Phenomena and Processes Biological Science Disciplines Publication Characteristics Analytical, Diagnostic and Therapeutic Techniques and Equipment Natural Science Disciplines Disciplines and Occupations Genetics Immunogenetic Phenomena Immunologic Techniques Immunogenetics Histocompatibility Methods Laboratory Manuals Immunity Immune System biology. biological sciences. physical sciences. methodology. Transplantation immunology Physical sciences Methodology Life sciences Immunity Immune system Histocompatibility Biology Immunogenetics Genre/Form Laboratory manuals Laboratory manuals. Manuels de laboratoire. Form Electronic book Author Christiansen, Frank T Tait, Brian D ISBN 9781617798429 1617798428 161779841X 9781617798412

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