| Description |
1 online resource (xv, 276 pages) : illustrations |
| Contents |
The role of medicinal chemistry in drug discovery / John A. Lowe III -- Process research: how much? how soon? / Neal G. Anderson -- Aromatase inhibitors for breast cancer : exemestane (Aromasin), anastrozole (Arimidex), and letrozole (Femara) / Jie Jack Li -- Quinolone antibiotics : levofloxacin (Levaquin), moxifloxacin (Avelox), gemifloxacin (Factive), and garenoxacin (T-3811) / Chris Limberakis -- Triazole antifungals : itraconazole (Sporanox), fluconazole (Diflucan), voriconazole (Vfend), and fosfluconazole (Prodif) / Andrew S. Bell -- Non-nucleoside HIV reverse transcriptase inhibitors / Arthur Harms -- Neuraminidase inhibitors for influenza : oseltamivir phosphate (Tamiflu) and zanamivir (Relenza) / Douglas S. Johnson and Jie Jack Li -- Peroxisome proliferator-activated receptor (PPAR) agonists for type 2 diabetes / Jin Li -- Angiotensin AT1 antagonists for hypertension / Larry Yet -- Leading ACE inhibitors for hypertension / Victor J. Cee and Edward J. Olhava -- Dihydropyridine calcium channel blockers for hypertension / Daniel P. Christen -- Second-generation HMG-CoA reductase inhibitors / Jeffrey A. Pfefferkorn -- Cholesterol absorption inhibitors: ezetimibe (zetia) / Stuart B. Rosenblum -- Dual selective serotonin and norepinephrine reuptake inhibitors (SSNRIs) for depression / Marta Piñeiro-Núñez -- GABA receptor agonists for insomnia : zolpidem (Ambien), zaleplon (Sonata), eszopiclone (Estorra, Lunesta), and indiplon / Peter R. Guzzo -- Ligands: neurontin (Gabapentin) and lyrica (Pregabalin) / Po-Wai Yuen -- Approved treatments for attention deficit hyperactivity disorder : amphetamine (Adderall), methylphenidate (Ritalin), and atomoxetine (Straterra) / David L. Gray |
| Summary |
The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis.:.; Edited by prominent scientists working in drug discovery for Pfizer.; Meets |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Drugs -- Design.
|
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Pharmaceutical chemistry.
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Drug Design
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Chemistry, Pharmaceutical -- methods
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Chemistry, Pharmaceutical
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MEDICAL -- Drug Guides.
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MEDICAL -- Pharmacology.
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MEDICAL -- Pharmacy.
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MEDICAL -- Nursing -- Pharmacology.
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Drugs -- Design
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Pharmaceutical chemistry
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| Form |
Electronic book
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| Author |
Johnson, Douglas S. (Douglas Scott), 1968-
|
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Li, Jie Jack.
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| ISBN |
9780470134962 |
|
0470134968 |
|
9780470134979 |
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0470134976 |
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9786610916771 |
|
6610916772 |
|
9781118678466 |
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111867846X |
|
