| Description |
1 online resource (665 pages) |
| Contents |
Front cover; Foreword; Preface to the Third Edition; Preface to the Second Edition; Preface to the First Edition; Contents; Contributors; 1 The Pathophysiology of Graft-vs.-Host Disease; I. ACUTE GVHD PATHIOPHYSIOLOGY: A THREE-STEP MODEL; A. Step 1: Effects of SCT Conditioning; B. Step 2: Donor T-Cell Activation and Cytokine Secretion; C. Step 3: Cellular and Inflammatory Effectors; II. GVHD PREVENTION AND TREATMENT: TRANSLATION TO CLINICAL SCT; A. Step 1: Reduced Intensity Conditioning Regimens; B. Step 2: Modulation of Donor T Cells |
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C. Step 3: Blockade of Inflammatory Stimulation and EffectorsIII. SYNGENEIC GRAFT-VS.-HOST DISEASE; IV. CONCLUSIONS; REFERENCES; 2 Animal Models of Graft-vs.-Host Disease; I. INTRODUCTION; II. HOST RESISTANCE TO DONOR CELL ENGRAFTMENT; III. GVHD DIRECTED TO MHC ANTIGENS; A. GVHD to MHC Class I Antigens; B. CD8-Mediated GVHD with Donor Marrow; C. CD8-Mediated GVHD with Host Marrow; D. Effect of CD4; E. GVHD to MHC Class II Antigens; F. CD4-Mediated GVHD with Donor Marrow; G. CD4-Mediated GVHD with Host Marrow; H. High Doses of Donor CD4; IV. GVHD IN NONIRRADIATED HOSTS |
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V. GVHD TO MINOR HISTOCOMPATIBILITY ANTIGENSA. MiHA Target Antigens; B. Features of Anti-miHA GVHD; C. Role of CD8+ Cells; D. Role of CD4+ Cells; VI. STRATEGIES TO SEPARATE GVHD FROM GVL EFFECTS; VII. IMMUNOPATHOLOGY; VII. SUMMARY; REFERENCES; 3 Graft-vs.-Host Disease as a Th1-Type Process: Regulation by Th2-Type Cells; I. INTRODUCTION; II. Th1/Th2 BIOLOGY; III. Th1/Th2 BIOLOGY IN VIVO IN HEALTH AND DISEASE; IV. PATHOGENESIS OF GVHD AS A Th1-TYPE PROCESS; V. Th2-TYPE MODULATION OF GVHD; VI. CO-STIMULATED Th2 CELLS: CLINICAL EVALUATION; VII. Th1/Th2 MODULATION OF GVHD: FUTURE DIRECTIONS |
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H. The PD-1/PD-L1,-2 PathwayI. Tolerance Induction by Ex Vivo Approaches; IV. REGULATORY CELLS AND ALLOGENEIC IMMUNE RESPONSES A. Overview; B. NKT Cells; C. Regulatory T(CD41/CD251) Cells; V. CONCLUSION; ACKNOWLEDGMENT; REFERENCES; 5 Chemokines and Graft-vs.-Host Disease; I. INTRODUCTION; II. THE CHANGING PARADIGM OF GVHD AND ITS STUDY; III. CHEMOKINES AND THE PATHOGENESIS OF ACUTE GVHD A. GVHD Pathophysiology; B. Chemokine Biology; IV. CHEMOKINES AND LEUKOCYTE TRAFFICKING DURING GVHD A. Stem Cell Homing; B. Antigen Presentation and T-Cell Activation |
| Summary |
With detailed contributions from more than 40 leading authorities on the topic, this Third Edition comprehensively explores the immunobiology, pathophysiology, and clinical manifestations of graft-versus-host disease (GVHD)-offering sections revealing the most up-to-date research on immune activation and dysregulation, the pathophysiology of target organ damage, and GVHD prevention and treatment |
| Bibliography |
REFERENCES4 Role of T-Cell Costimulation and Regulatory Cells in Allogeneic Hematopoietic Cell Transplantation; I. TOLERANCE INDUCTION BY REGULATING ANTIGEN-SPECIFIC T-CELL RESPONSES; II. OVERVIEW OF IMMUNE RESPONSE REGULATION; III. COSTIMULATORY PATHWAYS AND MODULATION OF ALLOGENEIC T-CELL RESPONSES A. The CD28/CTLA-4 (CD152) : B7-1 (CD80) /B7-2 (CD86) Pathway; B. The CD40L (CD154) : CD40 Pathway; C. The 4-1BB (CD137) : 4-1BBL (CD137L) Pathway; D. The OX40 (CD134) : OX40L (CD134L) Pathway; E. The Inducible Costimulator (ICOS) /ICOSL Pathway; F. The LIGHT-HVEM Pathway; G. The CD30/CD30L Pathway |
| Notes |
C. Cellular Recruitment to GVHD Target Organs |
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Print version record |
| Subject |
Graft versus host disease.
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Graft vs Host Disease
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Graft versus host disease
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| Form |
Electronic book
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| Author |
Cooke, Kenneth
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Deeg, H. Joachim
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| ISBN |
9781420030808 |
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1420030809 |
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