| Description |
1 online resource (xxiii, 406 pages) : illustrations (chiefly color) |
| Contents |
880-01 Overview of the immune system -- Innate immunity -- Adaptive immunity -- Immunogens and antigens -- Antibody structure and function -- Antigen-antobody interactions, immune assays, and experimental systems -- The genetic basis of antibody structure -- Biology of the B lymphocyte -- How T cells recognize antigen : the role of the major histocompatibility complex -- Biology of the T lymphocyte -- Activation and function of T cells -- Cytokines -- Tolerance and autoimmunity -- Complement -- Hypersensitivity : type I -- Hypersensitivity : types II and III -- Hypersensitivity : type IV -- Immunodeficiency disorders and neoplasias of the lymphoid system -- Transplantation -- Tumor immunology -- Resistance and immununization to infectious diseases |
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880-01/(S Contents note continued: CD8+ T-Cell Killing of Target Cells, -- MHC Restriction and CD8+ T Cell Killer Function, -- Memory T Cells, -- Function of Other Subsets of T Cells, -- NKT Cells, -- γδ T Cells, -- Innate Lymphoid Cells, -- References and Bibliography, -- Review Questions, -- Answers to Review Questions, -- Introduction, -- History of Cytokines, -- Pleiotropic and Redundant Properties of Cytokines, -- General Properties of Cytokines, -- Common Functional Properties, -- Common Systemic Activities, -- Common Cell Sources and Cascading Events, -- Functional Categories of Cytokines, -- Cytokines That Facilitate Innate Immune Responses, -- Cytokines That Regulate Adaptive Immune Responses, -- Cytokines That Induce Differentiation of Distinct T-Cell Lineages, -- Cytokines That Inhibit Lineage-Specific T-Cell Differentiation, -- Cytokines That Promote Inflammatory Responses, -- Cytokines That Affect Leukocyte Movement, -- Cytokines That Stimulate Hematopoiesis, -- Cytokine Receptors, -- Cytokine Receptor Families, -- Common Cytokine Receptor Chains, -- Cytokine Receptor-Mediated Signal Transduction, -- Role of Cytokines and Cytokine Receptors in Disease, -- Toxic Shock Syndrome, -- Bacterial Septic Shock, -- Cancers, -- Autoimmunity and Other Immune-Based Diseases, -- Therapeutic Exploitation of Cytokines and Cytokine Receptors, -- Cytokine Inhibitors/Antagonists, -- Reversing Cellular Deficiencies, -- Treatment of Immunodeficiencies, -- Treatment of Patients with Cancer, Transplanted Organs, and Tissues, and Viral Infections, -- Treatment of Allergies and Asthma, -- References and Bibliography, -- Review Questions, -- Answers to Review Questions, -- Introduction, -- Central Tolerance, -- Mechanisms of Central Tolerance: T and B Cells, -- Mechanisms of Central Tolerance: B Cells, -- Peripheral Tolerance, -- Anergy, -- Regulatory T Cells, -- Fas-FasL Interactions, -- Oral Tolerance, -- Immune Privilege, -- Autoimmunity and Disease, -- Genetic Susceptibility, -- Environmental Susceptibility, -- Drug and Hormonal Triggers of Autoimmunity, -- Autoimmune Diseases, -- Autoimmune Diseases in Which Antibodies Play a Predominant Role in Mediating Organ Damage, -- Autoimmune Diseases in Which T Cells Play a Predominant Role in Organ Damage, -- Therapeutic Strategies, -- References and Bibliography, -- Review Questions, -- Answers to Review Questions, -- Introduction, -- Overview of Complement Activation, -- Classical Pathway, -- Lectin Pathway, -- Alternative Pathway, -- Steps Shared by All Pathways: Activation of C3 and C5, -- Terminal Pathway, -- Regulation of Complement Activity, -- Biologic Activities of Complement, -- Production of Opsonins, -- Production of Anaphylatoxins, -- Lysis, -- Other Important Complement Functions, -- Complement Deficiencies, -- References and Bibliography, -- Review Questions, -- Answers to Review Questions, -- Introduction, -- Hypersensitivity, -- Coombs-Gell Hypersensitivity Designations, -- General Characteristics of Allergic Reactions, -- Sensitization Phase, -- TH2 Cell Dependency of IgE Antibody Production, -- Activation Phase, -- Effector Phase, -- Preformed Mediators, -- Newly Synthesized Mediators, -- Late-Phase Reaction, -- Clinical Aspects of Allergic Reactions, -- Allergic Rhinitis, -- Food Allergies, -- Atopic Dermatitis, -- Asthma, -- Clinical Tests for Allergies and Clinical Intervention, -- Detection, -- Intervention, -- Protective Role of IgE, -- References and Bibliography, -- Review Questions, -- Answers to Review Questions, -- Introduction, -- Type II Hypersensitivity, -- Complement-Mediated Reactions, -- Antibody-Dependent Cell-Mediated Cytotoxicity, -- Antibody-Mediated Cellular Dysfunction, -- Examples of Type II Hypersensitivity Reactions, -- Transfusion Reactions, -- Drug-Induced Reactions, -- Rhesus Incompatibility Reactions, -- Reactions Involving Cell Membrane Receptors, -- Reactions Involving Other Cell Membrane Determinants, -- Type III Hypersensitivity, -- Systemic Immune Complex Disease, -- Localized Immune Complex Disease, -- References and Bibliography, -- Review Questions, -- Answers to Review Questions -- Introduction, -- General Characteristics and Pathophysiology of DTH, -- Mechanisms Involved in DTH, -- Examples of DTH, -- Contact Sensitivity, -- Granulomatous Hypersensitivity, -- Tuberculin-Type Hypersensitivity, -- Allograft Rejection, -- Additional Examples of DTH, -- Treatment of DTH, -- References and Bibliography, -- Review Questions, -- Answers to Review Questions, -- Introduction, -- Immunodeficiency Syndromes, -- Primary Immunodeficiency Syndromes, -- Immunodeficiency Disorders Associated with T Cells and Cell-Mediated Immunity, -- B-Cell-Associated or Immunoglobulin-Associated Immunodeficiency Disorders, -- Disorders of T-B Interactions, -- Phagocytic Dysfunctions, -- Natural Killer Cell Deficiency, -- Diseases Caused by Abnormalities in the Complement System, -- Secondary Immunodeficiency Diseases, -- Acquired Immunodeficiency Syndrome, -- Initial Description and Epidemiology, -- Human Immunodeficiency Virus, -- Clinical Course, -- Prevention, Control, Diagnosis, and Therapy of HIV Infection, -- Neoplasms of Lymphoid System, -- B-Cell Neoplasms, -- Mature B-Cell Neoplasms, -- Plasma Cell Neoplasms, -- T-Cell Neoplasms, -- Mature T-Cell Neoplasms, -- Immunotherapy, -- References and Bibliography, -- Review Questions, -- Answers to Review Questions, -- Introduction, -- Relationship between Donor and Recipient, -- Immune Mechanisms Are Responsible for Allograft Rejection, -- Categories of Allograft Rejection, -- Hyperacute Rejection, -- Acute Rejection, -- Chronic Rejection, -- Role of MHC Molecules in Allograft Rejection, -- Mechanisms of Alloantigen Recognition by T Cells, -- Role of T Cell Lineages and Cytokines in Allograft Rejection, -- Laboratory Tests Used in Tissue Typing, -- Prolongation of Allograft Survival: Immunosuppresive Therapy, -- Anti-Inflammatory Agents, -- Cytotoxic Drugs, -- Agents That Interfere with Cytokine Production and Signaling, -- Immunosuppressive Antibody Therapy, -- New Immunosuppressive Strategies and Frontiers, -- Hematopoietic Stem Cell Transplantation, -- Graft-versus-Host Disease, -- Xenogeneic Transplantation, -- Fetus: A Tolerated Allograft, -- References and Bibliography, -- Review Questions, -- Answers to Review Questions, -- Introduction, -- Tumor Antigens, -- Categories of Tumor Antigens, -- Normal Cellular Gene Products, -- Mutant Cellular Gene Products, -- Tumor Antigens Encoded by Oncogenes, -- Immunologic Factors Influencing the Incidence of Cancer, -- Effector Mechanisms in Tumor Immunity, -- B-Cell Responses to Tumors, -- Destruction of Tumor Cells by Opsonization and Phagocytosis, -- Antibody-Mediated Loss of Adhesive Properties of Tumor Cells, -- Cell-Mediated Responses to Tumor Cells, -- Destruction of Tumor Cells by T Lymphocytes, -- Antibody-Dependent Cell-Mediated Cytotoxicity, -- Destruction of Tumor by NK Cells, NIC/T Cells, and Cytokine-Activated Killer Cells, -- Destruction of Tumor Cells by Activated Macrophages and Neutrophils, -- Cytokines, -- Limitations of the Effectiveness of the Immune Response against Tumors, -- Immunodiagnosis, -- Detection of Myeloma Proteins Produced by Plasma Cell Tumors, -- Detection of α-Fetoprotein, -- Carcinoembryonic Antigen, -- Detection of Prostate-Specific Antigen, -- Cancer Antigen-125, -- Tumor Immunoprophylaxis, -- Immunotherapy, -- Other Immunotherapeutic Strategies in Cancer, -- References and Bibliography, -- Review Questions, -- Answers to Review Questions, -- Introduction, -- Host Defense against the Various Classes of Microbial Pathogens, -- Immunity to Viruses, -- Immunity to Bacteria, -- Immunity to Parasites, -- Immunity to Fungi, -- Mechanisms by Which Pathogens Evade the Immune Response, -- Encapsulated Bacteria, -- Toxins, -- Superantigens, -- Antigenic Variation, -- Intracellular Survival, -- Suppression of the Immune System, -- Extracellular Enzymes, -- Expression of Antibody-Binding Proteins, -- Principles of Immunization, -- Objectives of Immunization, -- Active Immunizations, -- Recommended Immunizations, -- Use of Vaccines in Selected Populations, -- Basic Mechanisms of Protection, -- Significance of the Primary and Secondary Responses, -- Age and Timing of Immunizations, -- Vaccine Precautions, -- Site of Administration of Antigen, -- Hazards, -- Recent Approaches to Production of Vaccines, -- Vaccines Produced by Recombinant DNA, -- Conjugated Polysaccharides, -- Synthetic Peptide Vaccines, -- Virus-Carrier Vaccine, -- Bacterium-Carrier Vaccine, -- DNA Vaccines, -- Toxoids, -- Passive Immunization, -- Passive Immunization through Placental Antibody Transfer, -- Passive Immunization via Colostrum, -- Passive Antibody Therapy and Serum Therapy, -- Monoclonal and Polyclonal Preparations, -- Preparation and Properties of Human Immune Serum Globulin, -- Indications for the Use of Immune Globulin, -- Precautions on the Uses of Human Immune Serum Globulin Therapy, -- Colony-Stimulating Factors, -- References and Bibliography, -- Review Questions, -- Answers to Review Questions |
| Summary |
Immunology: A Short Course, Seventh Edition introduces allthe critical topics of modern immunology in a clear and succinct yet comprehensive fashion. The authors offer uniquely-balanced coverage of classical and contemporary approaches and basic and clinical aspects. The strength of Immunology: A Short Course is in providing a complete review of modern immunology without the burden of excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics, illustrated by uniformly drawn, full-color illustrations and photographs |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from resource home page (ebrary, viewed November 24, 2015) |
| Subject |
Immunology.
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Immune system.
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Immunity.
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Immunologic diseases.
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Immune System Phenomena
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Immunity
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Allergy and Immunology
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Immune System Diseases
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Immunologic diseases
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Immunity
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Immune system
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Immunology
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| Form |
Electronic book
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| Author |
Sunshine, Geoffrey, author.
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| LC no. |
2014023773 |
| ISBN |
9781118396902 |
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1118396901 |
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9781118396896 |
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1118396898 |
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