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1 online resource (0 p.) |
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Issn Ser
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| Contents |
Intro -- Genes and Endocrine Signalling in Development and Homeostasis -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Ecdysteroid signalling in insects-From biosynthesis to gene expression regulation -- 1. Introduction -- 2. Pleiotropic functions of ecdysteroids during the insect life cycle -- 2.1. Cuticle formation and morphogenesis during embryogenesis -- 2.2. Moulting during post-embryonic development -- 2.3. Tissue degradation, remodelling, and morphogenesis during metamorphosis -- 2.4. Reproduction and stress responses during the adult stage -- 2.5. Polyphenism |
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3. Six steps of ecdysteroid signalling and their regulation -- 3.1. Biosynthesis -- 3.1.1. Ecdysteroidogenesis during embryonic development -- 3.1.2. Ecdysteroidogenesis during post-embryonic development -- 3.1.3. Ecdysteroidogenesis in the adult stage -- 3.2. Secretion -- 3.3. Circulation -- 3.4. Transport -- 3.5. Modification -- 3.6. Gene expression regulation -- 4. Concluding remarks -- Acknowledgements -- References -- Chapter Two: A decade with the juvenile hormone receptor -- 1. Introduction -- 2. From JH effects to discovering a JH receptor |
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2.1. Developmental action of JH: A take-home message from one paper -- 2.2. Mutual benefits of Drosophila and complementary insect models -- 3. Functional attributes defining Met/Gce as a JHR -- 3.1. Loss-of-function phenotypes consistent with JH deficiency -- 3.1.1. Metamorphosis -- 3.1.2. Female reproduction -- 3.2. Transcriptional regulation of JH-response genes -- 3.2.1. JHRs are bHLH-PAS protein complexes containing Met/Gce -- 3.2.2. Immediate target genes are driven by JH-response elements -- 3.3. Binding JHs as agonist ligands -- 3.3.1. Validation of JH binding through independent assays |
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3.3.2. Ligand selectivity and stereoselectivity -- 3.3.3. Delineating the JH-binding pocket -- 3.3.4. JH binding by Met/Gce is required for insect development -- 3.3.5. Insect Met and Tai confer JH responsiveness to mammalian cells -- 4. Molecular architecture and function of JHR -- 4.1. Functional parallels between Met/Gce and AhR -- 4.1.1. The canonical AhR pathway -- 4.1.2. Interactions with bHLH-PAS partners -- 4.1.3. The role of Hsp90/Hsp83 -- 4.1.4. Ligand-binding pockets and rich agonist repertoires -- 4.2. Nuclear import -- 4.3. Phosphorylation of JHR proteins |
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5. JHR as a target of insecticide action -- 5.1. Juvenoid IGRs are agonist ligands of JHR -- 5.2. Search for novel agonists and antagonists of JHR -- 5.2.1. Activators discovered via high-throughput and virtual screening -- 5.2.2. Inhibitors -- 6. Conclusion -- Acknowledgements -- References -- Chapter Three: The epitracheal endocrine system and associated signalling cascades in development, reproduction, and beha ... -- 1. Introduction -- 2. Epitracheal glands, inka cells, and ETH signalling -- 2.1. Inka cell peptides -- 2.2. Steroid regulation of inka cells -- 2.3. ETH receptors |
| Notes |
Description based upon print version of record |
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3. Initiation and scheduling of the ecdysis sequence |
| Subject |
Insects -- Physiology.
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Insects -- Physiology.
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| Form |
Electronic book
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| ISBN |
9780323854269 |
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0323854265 |
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