| Description |
1 online resource |
| Series |
Advances in Chromatography Ser. ; v. 57 |
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Advances in Chromatography Ser
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| Contents |
Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface -- In Memoriam -- Editors -- List of Contributors -- Chapter 1 Mobile Phase Effects in Reversed-Phase and Hydrophilic Interaction Liquid Chromatography -- 1.1 Introduction -- 1.2 Stationary Phases in Liquid Chromatography -- 1.2.1 Sample Distribution in Liquid Chromatography -- 1.2.2 Stationary and Mobile Phase Volumes in Column Liquid Chromatography -- 1.2.2.1 Fully Porous Packing Particles -- 1.2.2.2 Core-Shell Columns -- 1.2.2.3 Monolithic Columns -- 1.2.2.4 Micro-Pillar Array Columns |
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1.3 Phase Systems and Separation Modes in HPLC -- 1.3.1 Organic Solvent Normal-Phase (Adsorption) Chromatography -- 1.3.2 Reversed-Phase Chromatography -- 1.3.3 Hydrophilic Interaction Liquid Chromatography (HILIC) -- 1.4 Mobile Phase Effects on Retention -- 1.4.1 Solvent Adsorption in the Stationary Phase -- 1.4.2 The Mobile Phase-Retention Models -- 1.4.3 Modeling Gradient-Elution Liquid Chromatography -- 1.4.4 Structural Retention Correlations -- 1.4.5 Combined-Retention-Mechanism LC Systems -- 1.4.5.1 Mixed-Mode and Zwitterionic Stationary Phases -- 1.4.5.2 Serially Coupled HILIC/RP Columns |
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1.4.5.3 Dual-Mode Retention Mechanism on a Single Column -- 1.5 Conclusions, Further Perspectives -- References -- Chapter 2 Temperature Effects in Reversed-Phase Liquid Chromatography: Use in Focusing, Temperature-Stable Stationary Phases, Effect on Retention, and Viscous Dissipation -- 2.1 Introduction -- 2.2 On-Column Solute Focusing -- 2.2.1 Overview -- 2.2.2 Solute Band Focusing Theory -- 2.2.3 Capillary-Scale TASF -- 2.2.3.1 Overview -- 2.2.3.2 Multiplicative TASF -- 2.2.4 Analytical Scale TASF -- 2.2.4.1 The Effect of Column Diameter -- 2.2.4.2 Precolumn Design |
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2.2.4.3 Experimental Results -- 2.3 Stable Stationary Phases -- 2.3.1 Overview -- 2.3.2 Silica Supports -- 2.3.2.1 Sterically Protected Stationary Phases -- 2.3.2.2 Polymer Modified Silica -- 2.3.2.3 Robust Silica Particles -- 2.3.3 Other Stationary Phase Supports -- 2.3.4 Stationary Phases Based on the Thiol-yne Reaction -- 2.4 The Influence of Temperature on Retention -- 2.4.1 Neutral Analytes -- 2.4.1.1 Background on Retention Models for Neutral Analytes -- 2.4.1.2 Comparing Retention Models for Neutral Analytes -- 2.4.2 Ionizable Analytes -- 2.4.2.1 Overview |
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2.4.2.2 Effect of Buffer Ionization Enthalpy -- 2.4.2.3 What Is the pH of a Mobile Phase? -- 2.4.2.4 Retention Prediction -- 2.4.2.5 Conclusion -- 2.4.3 Temperature-Dependent Changes in Stationary Phases -- 2.5 The Effects of Viscous Dissipation -- 2.5.1 Overview -- 2.5.2 Temperature Profiles within a Column -- 2.5.3 Counteracting Band Broadening Caused by Viscous Dissipation -- 2.5.4 Adiabatic Columns -- Acknowledgments -- References -- Chapter 3 Kosmotropic Chromatography of Proteins: Theory and Practice -- 3.1 Introduction -- 3.2 Kosmotropicity in Chromatography |
| Summary |
For more than five decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to date information on a wide range of developments in chromatographic methods and applications. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill. This volume considers the achievements and legacy of Lloyd R. Snider in separation science and analytical chemistry. Key Features: Provides a historical perspective of the evolution of SMB technology together with a theoretical analysis of the most relevant underlying phenomena Presents a brief survey of the polar columns suitable for HILIC separations and pays special attention to the role of the mobile phase in RP and HILIC modes Describes recent strategies of method development in Kosmotropic chromatography Surveys the many approaches to avert the effects of temperature in reversed-phase liquid chromatographic separations Reviews separation of isotopic compounds by HPLC in relation to the advances of columns and stationary phases |
| Bibliography |
Includes bibliographical references |
| Notes |
Dr. Nelu Grinberg retired in 2016 as a Distinguished Research Fellow in the Chemical Development Department at Boehringer Ingelheim Pharmaceuticals in Ridgefield, CT. Prior to this, he worked for sixteen years in the Analytical Department at Merck Research Laboratories in Rahway, NJ, where he was a Senior Research Fellow. He has authored and coauthored over 118 publications, including articles and book chapters. He is currently Editor and Chief of the Journal of Liquid Chromatography and Related Techniques, Editor of the book series Chromatographic Science Series, and Co-editor of the Advances in Chromatography series. He is also the President of the Connecticut Separation Science Council and a Koltoff fellow of the Hebrew University of Jerusalem. Dr. Grinberg obtained his Ph. D. in Chemistry from the Technical University of lasi in Romania. He conducted postdoctoral research with Professor Barry Karger at Northeastern University in Boston, Massachusetts, and with Professor Emanuel Gil-Av at The Weizmann Institute of Science in Rehovot, Israel. Peter Carr received his B.S. in Chemistry (1965) from the Polytechnic Institute of Brooklyn where he worked with Professor Louis Meites, and a Ph. D. in Analytical Chemistry at Pennsylvania State University (1969) under the guidance of Professor Joseph Jordan. Following appointments at Brookhaven National Laboratory, Stanford University Medical School and the University of Georgia (Athens), in 1977, Dr. Carr joined the faculty at the University of Minnesota where he became Professor of Chemistry in 1981. He has been a consultant to Leeds and Northrup Co., Hewlett-Packard and the 3M Company, and was the founder and first President of ZirChrom Separations Inc. In 1986, he became an Associate Director of the Institute for Advanced Studies in Biological Process Technology at the University of Minnesota. He has been President of the Symposium on Analytical Chemistry in the Environment (1976), founder and first President of the Minnesota Chromatography Forum, and Chairman of the Subdivision of Chromatography and Separation Science of the Analytical Chemistry Division of the American Chemical Society (1988-1989). Prof. Carr has served on the Editorial Advisory Boards of Analytical Chemistry, Talanta, The Microchemical Journal, LC/GC, Journal of Chromatography, Chromatographia and Separation Science and Technology |
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Online resource; title from digital title page (viewed on July 30, 2020) |
| Subject |
Chromatographic analysis.
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Chromatography
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chromatography.
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SCIENCE -- Chemistry -- Analytic.
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SCIENCE -- Chemistry -- Industrial & Technical.
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Chromatographic analysis
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| Form |
Electronic book
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| Author |
Grinberg, Nelu, 1950- editor.
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Carr, Peter W., editor.
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| ISBN |
9781000062014 |
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1000062015 |
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9781003024385 |
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1003024386 |
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9781000061987 |
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1000061981 |
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9781000061956 |
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1000061957 |
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