| Description |
1 online resource (246 p.) |
| Contents |
Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface -- Editors -- Contributors -- Chapter 1 Alternative Splicing -- 1.1 Introduction -- 1.2 Gene Structure, Transcription and Protein Synthesis -- 1.3 Pre-mRNA Processing -- 1.3.1 The Spliceosome -- 1.3.2 RNA Editing -- 1.4 Alternative Splicing in Physiology -- 1.4.1 Species- or Tissue-Specific Splicing -- 1.4.2 Developmental Splicing -- 1.4.3 Activity- and Hormone-Dependent Splicing -- 1.4.4 Circadian Regulation of Splicing -- 1.4.5 Splicing and Disease -- 1.5 Summary -- Suggested Readings |
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Chapter 2 Calmodulin Regulation of Ion Channels -- 2.1 Introduction -- 2.2 General Principles -- 2.3 CaV Channels -- 2.3.1 CaM as the Ca2+ Sensor for CDI -- 2.3.2 Functional Bipartition of Calmodulin and Selectivity for Local/Global Calcium Sources -- 2.3.3 Molecular Basis of CaM Regulation -- 2.3.4 Biological Consequences and Prospects for New Disease Therapies -- 2.4 NaV Channels -- 2.4.1 Ca2+-Dependent Regulation -- 2.4.2 Ca2+-Independent Regulation -- 2.5 TRP Channels -- 2.6 CaM Regulation of Potassium Channels -- 2.6.1 EAG -- 2.6.2 SK Channels -- 2.6.3 KCNQ (KV7) |
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2.7 Ryanodine Receptor (RyR) -- 2.8 NMDA Receptor -- 2.9 Disrupted Ca2+/CaM Regulation in Disease -- Suggested Readings -- Chapter 3 Regulation of G Protein-Gated Inwardly Rectifying K+ Channel Activity -- 3.1 Vagal Inhibition of Heart Rate -- 3.2 Molecular Components of KACh/GIRK Channel Regulation -- 3.2.1 GTP-Binding (G) Proteins and Their Signaling to KACh -- 3.2.2 GIRK Channel Cloning, Expression and Assembly -- 3.2.3 GIRK Channel Gating -- 3.3 Regulation of Activity by Posttranslational Modifications and Drugs -- 3.3.1 GIRK Channels as Drug Targets -- 3.4 Structural Insights |
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3.5 Future Questions -- Acknowledgments -- Suggested Readings -- Chapter 4 Regulation of Ion Channels by Membrane Lipids -- 4.1 Introduction -- 4.2 Composition of Biological Membranes -- 4.3 Glycerophospholipids -- 4.3.1 Neutral Phospholipids: PC and PE -- 4.3.2 Phosphatidylserine -- 4.3.3 PI and Phosphoinositides -- 4.3.3.1 PI(4,5)P2, the Master Regulator of Plasma Membrane Ion Channels, and Its Precursor PI(4)P -- 4.3.3.2 PI(3,4,5)P3 and PI(3,4)P2, the Products of PI3-Kinases in the Plasma Membrane -- 4.3.3.3 PI(3,5)P2, a Specific Cofactor for Intracellular Ion Channels |
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4.3.4 PG, Cardiolipin and Bacterial Ion Channels -- 4.4 Cholesterol -- 4.5 Sphingolipids -- 4.6 Conclusions and Future Perspective -- Suggested Readings -- Chapter 5 Ion Channels of the Heart -- 5.1 Generation of the Cardiac Action Potential and Excitation-Contraction Coupling -- 5.2 Cardiac Na Channel Physiology and Pathophysiology -- 5.2.1 Channel Structure and Function -- 5.2.2 Inherited and Acquired Cardiac Diseases -- 5.3 Cardiac L-Type Ca2+ Channel Physiology and Pathophysiology -- 5.4 Cardiac Ryanodine Receptors -- 5.4.1 Channel Function and Regulation |
| Summary |
This three-volume textbook provides a wide-ranging reference source on ion channels for students, instructors, and researchers. Volume III covers key ion channel regulators, the role of ion channels in selected physiological systems, and examples of mutations and dysfunction in selected diseases |
| Notes |
Description based upon print version of record |
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5.4.2 Inherited and Acquired Cardiac Diseases and RyR2 Function |
| Form |
Electronic book
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| Author |
Trudeau, Matthew C
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| ISBN |
9781000857849 |
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1000857840 |
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