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Title Molecular mechanisms of spondyloarthropathies / edited by Carlos López-Larrea, Roberto Díaz-Peña
Published New York, N.Y. : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, ©2009


Description 1 online resource (xxv, 314 pages) : illustrations (some color)
Series Advances in experimental medicine and biology ; v. 649
Advances in experimental medicine and biology ; v. 649.
Contents Clinical assessment in the spondyloarthropathies / Ruth Wittoek and Herman Mielants -- Imaging in spondyloarthritis / Walter P. Maksymowych -- Spondyloarthritis, diffuse idiopathic skeletal hyperostosis (DISH) and chondrocalcinosis / Jácome Brügues Armas, Ana Rita Couto, and Bruno Filipe Bettencourt -- The enthesis organ concept and its relevance to the spondyloarthropathies / Michael Benjamin and Dennis McGonagle -- Synovial and mucosal immunopathology in spondyloarthritis / Bernard Vandooren, Paul P. Tak, and Dominique Baeten -- Bone loss in the spondyloarthropathies : role of osteoclast, RANKL, RANK, and OPG in the spondyloarthropathies / Allen P. Anandarajah and Edward M. Schwarz -- RANKL/RANK as key factors for osteoclast development and bone loss in arthropathies / Andreas Leibbrandt and Josef M. Penninger -- Bone formation versus bone resorption in ankylosing spondylitis / Georg Schett
Biomarkers in spondyloarthropathies / Chun-Hsiung Chen, David Tak Yan Yu, and Chung-Tei Chou -- Therapy of spondyloarthritides / Jürgen Braun -- Genomewide screens in ankylosing spondylitis / Matthew A. Brown -- Subtypes of HLA-B27 : history and implications in the pathogenesis of ankylosing spondylitis / John D. Reveille -- Implications of structural and thermodynamic studies of HLA-B27 subtypes exhibiting differential association with ankylosing spondylitis / Andreas Ziegler [and others] -- HLA-B27-bound peptide repertoires : their nature, origin and pathogenetic relevance / José A. López de Castro -- Biochemical features of HLA-B27 and antigen processing / Simon J. Powis, Susana G. Santos and Antony N. Antoniou
HLA-B27 misfolding and spondyloarthropathies / Robert A. Colbert [and others] -- HLA-B27 and host-pathogen interaction / Anna S. Sahlberg, Kaisa Granfors and Markus A. Penttinen -- Animal models of spondyloarthritis / Joel D. Taurog -- T-cell responses against viral and self-epitopes and HLA-B27 subtypes differentially associated with ankylosing spondylitis / Maria T. Fiorillo and Rosa Sorrentino -- Dendritic cell : T-cell interactions in spondyloarthritis / J.S. Hill Gaston [and others] -- The role of B27 heavy chain dimer immune receptor interactions in spondyloarthritis / Simon Kollnberger and Paul Bowness -- KIR genes and their role in spondyloarthropathies / Roberto Díaz-Peña, Miguel Ángel Blanco-Gelaz and Carlos López-Larrea -- Innate immunity of spondyloarthritis : the role of toll-like receptors / Robert D. Inman
Summary It is obvious that over the period an enormous amount of information concerning SpA and HLA-B27 has accumulated, and this has been reflected in the knowledge of molecular mechanism of the spondyloarthropathies. This book aims to synthesize this knowledge and presents the various studies concerning the basic research of SpA
Bibliography Includes bibliographical references and index
In Springer eBooks
Subject Spondyloarthropathies -- Molecular aspects
Spondylarthropathies -- genetics
MEDICAL -- Orthopedics.
HEALTH & FITNESS -- Diseases -- Musculoskeletal.
MEDICAL -- Rheumatology.
Spondylarthropathies -- genetics.
Spondyloarthropathies -- Molecular aspects.
Sciences de la vie.
Form Electronic book
Author López-Larrea, Carlos, 1953-
Díaz-Peña, Roberto, M.A.
ISBN 9781441902979