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Book Cover
E-book
Author Brooks, Susan

Title Functional and Molecular Glycobiology
Published Milton : CRC Press LLC, 2002

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Description 1 online resource (359 p.)
Contents Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Acknowledgements -- Abbreviations -- Glossary of Terms -- Foreword -- Preface -- Plate 1 -- 1: An Introduction to Carbohydrate Chemistry -- Introduction -- What are Carbohydrates? -- Monosaccharides are Aldoses and Ketoses -- A Carbon Atom may be Asymmetric -- The Concept of Chirality -- Monosaccharide 'Family Trees' -- D-Forms and L-Forms of Carbohydrates -- Numbering the Carbon Atoms in a Monosaccharide Molecule -- (+) and (-) Forms of Carbohydrates -- The Concept of Epimerization
The Complex Carbohydrate Structure Database (CCSD) -- Further Reading -- 2: Enzymes of Glycosylation -- The Glycosyltransferases -- Introduction -- Enzymes of Glycosylation -- Glycosidases and Glycosyltransferases -- Nomenclature of Glycosyltransferases -- Initiation of Glycosylation by Glycosyltransferases -- Building Oligosaccharides -- Transglycosylation Reactions -- Sugar Donors -- The 'One Enzyme-One Linkage' Rule -- and Exceptions to It -- Cation and pH Requirements of Glycosyltransferases -- Localization of Glycosyltransferases along the Secretory Pathway
Substrate Recognition by Glycosyltransferases -- Glycosyltransferase 'Families' -- The Molecular Structure and Organization of Glycosyltransferases -- Cell-Surface and Secreted Forms of Glycosyltransferases -- Regulation of Glycosyltransferase Expression and Activity -- Evidence for the Function of Glycans Derived from Glycosyltransferase Mutants -- Further Reading -- 3: Polysaccharides -- Introduction -- How are Polysaccharides Defined? -- Structural Polysaccharides -- Gums, Mucilages and Other Plant Polysaccharides -- Storage Polysaccharides -- Further Reading -- 4: N-Linked Glycoproteins
What are N-Linked Glycoproteins? -- Biosynthesis of N-Linked Oligosaccharides -- Common Structural Features of N-Linked Oligosaccharides and the Generation of Structural Diversity -- Functions of N-Linked Oligosaccharides -- Further Reading -- 5: O-Linked (Mucin-Type) Glycoproteins -- What are O-Linked Glycoproteins? -- The Relationship between N-Linked and O-Linked Glycoproteins -- Types of O-Linked Glycoproteins -- Structure of O-Linked Mucin-Type Glycoproteins -- An Overview of the Biosynthesis of O-Linked Glycoproteins -- Synthesis of O-Linked Glycans
Notes Description based upon print version of record
Glycosyltransferase Enzymes Involved in O-Linked Oligosaccharide Synthesis
Form Electronic book
Author Dwek, M
Schumacher, Udo
ISBN 9781000943740
1000943747