| Description |
1 online resource (309 pages) : illustrations |
| Contents |
Annual Review of Gerontology and Geriatrics, Volume 34, 2014; Half-Title Page; Editors; Title Page; Copyright; Contents; About the Volume Editor; Contributors; Previous Volumes in the Series; Forthcoming Volume in the Series; Preface; CHAPTER 1: Longevity Pathways in Mammalian Stem Cells; ABSTRACT; INTRODUCTION; LONGEVITY PATHWAYS; Insulin/IGF1-FOXO Pathway; Mechanistic Target of Rapamycin (mTOR) Pathway; AMP-Activated Protein Kinase; Sirtuins; LONGEVITY PATHWAYS IN ADULT STEM CELLS IN MAMMALS; Role of FOXO Transcription Factors in Mammalian Adult Stem Cells |
|
MTOR Pathway in Mammalian Adult Stem CellsAMPK in Mammalian Adult Stem Cells; Sirtuins in Mammalian Adult Stem Cells; LONGEVITY PATHWAYS IN MAMMALIAN EMBRYONICSTEM CELLS; FOXO Transcription Factors in Embryonic Stem Cells; mTOR Pathway in ESCs; AMPK and Sirtuins in ESCs; LONGEVITY PATHWAYS AND REPROGRAMMING TO iPSCs; Insulin/IGF1-FOXO Pathway in Reprogramming; mTOR Pathway in Reprogramming; AMPK in Reprogramming; Sirtuins in Reprogramming; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 2: Essential Genes and Lifespan; ABSTRACT; DEVELOPMENTAL ARREST AS A SURROGATE FOR LONGEVITY MUTANTS |
|
RNAi DRIVES THE DISCOVERY OF ESSENTIAL LONGEVITY GENESTARGETING ESSENTIAL PATHWAYS IN NATURE; THE DISPENSABILITY OF ESSENTIAL GENE PARADOX; PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 3: Oxygen and Aging; ABSTRACT; INTRODUCTION; OXYGEN AVAILABILITY MODULATES AGING; Hyperoxia; Hypoxia; THE ROLE OF THE HYPOXIC RESPONSE IN AGING; HIF-1 and Aging in C. elegans; Mammalian HIFs in Aging and Disease; INTERACTIONS BETWEEN OXYGEN, THE HYPOXIC RESPONSE, AND KNOWN LONGEVITY PATHWAYS; Dietary Restriction; mTOR; Sirtuins and HIF Proteins; CONCLUSIONS; REFERENCES |
|
CHAPTER 4: Aging, Disease, and Longevity in MiceABSTRACT; EVALUATION OF SURVIVAL DATA; BUILDING A CASE THAT AN INTERVENTION SLOWS AGING; MOUSE LONGEVITY MODELS; Early, Transient CR Extends Mouse Longevity; Inhibition of mTORC1 Signaling Extends Mouse Lifespan; Many Mouse Strains With Reduced Activity of GH and/or IGF1 Show Extended Longevity; Checkpoint Controls and Longevity; Increased Telomerase Dosage Extends Murine Lifespan; Longevity Associated With Mitochondrial Defects; Uncertainties Regarding Longevity of the p66 shc Mutant |
|
BubR1 Links Improved Maintenance of Euploidy With Increased LongevityAdenylyl Cyclase 5 Deficiency Promotes Cardiac Stress Resistance and Longevity; MODELS WITH IMPROVED HEALTHSPAN BUT NOT LIFESPAN; Reactive Oxygen Species: Complex Relationships With Aging and Age-Associated Disease; Sirtuins: Complex Relationships With Health and Lifespan; Proteostasis Promotes Maintenance of Organ Function With Age; Resveratrol Protects Against Sequelae of High Fat Feeding; FUTURE AVENUES; LONGEVITY WITHOUT GOOD HEALTH: TITHONIAN PARANOIA; ACKNOWLEDGMENTS; REFERENCES |
| Summary |
Enormous advances in our knowledge of genetic contributions to aging and disease, and in our understanding of the potential for manipulation of the aging process, have taken place during the past twenty years. This is the first volume in decades to consolidate this research in one place. It provides a broad and current overview of the most promising advances in genetic research on aging, current understanding of genetic contributions to the basic processes of aging, and age-related disease. The Review focuses on the aging process from lower organisms to man, and is organized in ascending order |
| Bibliography |
Includes bibliographical references at the end of each chapters and index |
| Notes |
Online resource; title from PDF title page (ebrary, viewed March 18, 2014) |
| Subject |
Geriatrics.
|
|
Gerontology.
|
|
Aging.
|
|
Geriatrics
|
|
Aging
|
|
gerontology.
|
|
MEDICAL -- Gynecology & Obstetrics.
|
|
Aging
|
|
Geriatrics
|
|
Gerontology
|
| Form |
Electronic book
|
| Author |
Sprott, Richard L., editor
|
|
Antonucci, Toni C., editor
|
| ISBN |
9780826199669 |
|
0826199666 |
|
