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Book Cover
Author Wostmann, Bernard S

Title Germfree and gnotobiotic animal models : background and applications / Bernard S. Wostmann
Published Boca Raton : CRC Press, ©1996


Description 1 online resource
Contents Cover -- Title Page -- Copyright Page -- Foreword -- The Author -- Table of Contents -- Chapter I: Introduction -- Chapter II: Early Growth, Body Weight, Reproduction, and Life Span -- General Aspects -- Growth -- Body Weight of the Mature Animal -- Reproduction -- Life Span -- Conclusions -- Chapter III: Anatomy, Morphology, and Function of the Gastrointestinal System -- General Aspects -- Stomach -- Small Intestine -- Cecum -- Large Intestine -- Conclusions -- Chapter IV: Morphology and Physiology, Endocrinology and Biochemistry -- General Aspects -- Energy Metabolism -- Liver Function
Cholesterol and Bile Acid Metabolism -- Rats and Mice -- Gerbils -- Dogs and Pigs -- Other Indicators of Function -- Water Balance and Kidney Function -- Mineral Metabolism -- Endocrine System -- Conclusions -- Chapter V: Nutrition -- General Aspects -- Early Rat and Mouse Diets -- Hand-Feeding of the Cesarian-Derived Newborn -- Solid Diets -- Further Development of Rat and Mouse Diets -- Sterilization of Solid Diets -- Metabolic Requirements of Germfree Rats and Germfree Mice -- Contributions of the Microflora -- Dietary Energy Requirements -- Proteins and Amino Acids
Vitamin B Complex -- Microflora Production -- Fat-Soluble Vitamins -- Minerals -- Inositol, Ubiquinone, and Queuine -- Chapter VI: The Chemically Defined Diet -- General Aspects -- Development of the Chemically Defined Diet -- Procedures -- Present Status -- Dietary Antigenicity and Immune Potential -- Chapter VII: Immunology, Including Radiobiology and Transplantation -- General Aspects -- Early Studies: Immune Potential of Germfree Rats and Mice Maintained on Solid Diets -- Antibody-Forming Potential -- Phagocytosis -- B Cells, T Cells, and NK Cells -- Immune Globulins -- Natural Antibody
Cytokinins -- Radiation Biology and Bone Marrow Transplantation -- Immunological Evaluation of GF Mice Maintained on a Chemically Defined, Low Molecular Weight Antigen-free Diet -- Conclusions -- Chapter VIII: Parasitology -- General Aspects -- Effects of the Microflora Via Nutrient Availability and the Immune System -- Protozoa -- Nematodes -- Helminths -- Schistosomiasis and Chagas Disease -- Cestodes -- Chapter IX: Pathology Over the Life Span of the Germfree Rat and the Germfree Mouse -- General Aspects -- Tumors and Tumor-Related Viruses -- Conclusions
Chapter X: Applications: Past, Present, and Future. Part I -- Introduction -- Microbial Action and Interaction in Gnotobiotic Systems. Colonization Resistance and Translocation Studies -- Controlled Microbial Association -- Monoassociation -- Microbial Interaction -- Bacteria-Yeast Interaction -- Colonization Resistance -- Materials With Antimicrobial Action -- Translocation Studies -- Chapter XI: Applications: Past, Present, and Future. Part II. Use of the Gnotobiote in the Study of Disease -- The Aging Syndrome -- Endpoint Studies -- Lobund Aging Study -- Cancer Research
Summary The germfree animal is reared in the laboratory to be bacteria free; its counterpart, the gnotobiotic animal, is exposed to select microorganisms. The need for such an animal model for use in biomedical studies was first expressed by Pasteur in the late 1800s. Subsequent development of germfree and gnotobiotic animals led to an explosion of studies on the effects of microflora and its components on the physiology and metabolism of the host. Germfree and Gnotobiotic Animal Models brings together the most notable points of early and recent studies and gives reference to the most pertinent literature
Bibliography Includes bibliographical references and index
Notes Bernard S. Wostmann (University of Notre Dame) (Author)
Subject Laboratory animals.
Germfree animals.
Diseases -- Animal models.
Germfree life.
Germ-Free Life
Animals, Laboratory
Disease Models, Animal
SCIENCE -- Life Sciences -- General.
Germfree life
Diseases -- Animal models
Germfree animals
Laboratory animals
Gnotobiotische Tiere
Form Electronic book
ISBN 9780138753320