| Description |
1 online resource (x, 299 pages) : illustrations (some color) |
| Series |
Methods in molecular biology, 1940-6029 ; v. 1793 |
|
Methods in molecular biology (Clifton, N.J.) ; v. 1793. 1064-3745
|
| Contents |
Introduction to epidemiological studies / Lazaros Belbasis and Vanesa Bellou -- Key concepts in genetic epidemiology / Kalliope Panoutsopoulou and Eleanor Wheeler -- Quality control of common and rare variants / Kalliope Panoutsopoulou and Klaudia Walter -- Genome-wide association studies / Abbas Dehghan -- Assessing rare variation in complex traits / Karoline Kuchenbaecker and Emil Vincent Rosenbaum Appel -- Meta-analysis of common and rare variants / Kyriaki Michailidou -- Gene-gene and Gene-environment interactions / Andrew T. DeWan -- Genetic association in the HLA region / Loukas Moutsianas and Javier Gutierrez-Achury -- Novel methods for family-based genetic studies / Qi Yan -- Methods for polygenic traits / Raha Pazoki -- Multivariate methods for meta-analysis of genetic association studies / Niki L. Dimou, Katerina G. Pantavou, Georgia G. Braliou, and Pantelis G. Bagos -- Methods of analysis and meta-analysis for identifying differentially expressed genes / Panagiota I Kontou, Athanasia Pavlopoulou, and Pantelis G. Bagos -- Primer in mendelian randomization methodology with a focus on utilizing published summary association data / Niki L. Dimou and Konstantinos K. Tsilidis -- Copy number variation / Aurelien Mace, Zoltan Kutalik, and Armand Valsesia -- From identification to function : current strategies to prioritise and follow-up GWAS results / Antonio J. Berlanga-Taylor -- Translating human genetics into novel drug targets / Karol Estrada |
| Summary |
This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented. The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Epidemiology.
|
|
Epidemiology
|
|
Epidemiologic Methods
|
|
Medical genetics.
|
|
Medical -- Genetics.
|
|
Epidemiology
|
| Genre/Form |
Laboratory manuals.
|
|
Manuels de laboratoire.
|
| Form |
Electronic book
|
| Author |
Evangelou, Evangelos, editor
|
| ISBN |
9781493978687 |
|
1493978683 |
|
9781493978670 |
|
1493978675 |
|
