Uniform Title Clinical epidemiology (Parfrey) Title Clinical epidemiology : practice and methods / edited by Patrick S. Parfrey and Brendan J. Barrett

Edition Third edition Published New York, NY : Humana Press, [2021]

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Description 1 online resource (xiii, 650 pages) : illustrations (some color) Series Methods in molecular biology, 1940-6029 ; volume 2249 Methods in molecular biology (Clifton, N.J.) ; v. 2249. 1064-3745 Contents On Framing the Research Question and Choosing the Appropriate Research Design -- Bias in Clinical Research -- Definitions of Bias in Clinical Research -- Research Ethics for Clinical Researchers -- Ethical, Legal, and Social Issues (ELSI) in Clinical Genetics Research -- Longitudinal Studies 1: Determinants of Risk -- Longitudinal Studies 2: Modeling Data using Multivariate Analysis -- Longitudinal Studies 3: Data Modeling using Standard Regression Models and Extensions -- Longitudinal Studies 4: Matching Strategies to Evaluate Risk -- Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic Disease -- Randomized Controlled Trials 1: Design -- Randomized Controlled Trials 2: Analysis -- Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes -- Randomized Controlled Trials 4: Planning, Analysis, and Interpretation of Quality of Life Studies -- Randomized Controlled Trials 5: Biomarkers and Surrogates/Outcomes -- Randomized Controlled Trials 6: Determining the Sample Size and Power for Clinical Trials and Cohort Studies -- Randomized Controlled Trials 7: On Contamination and Estimating the Actual Treatment Effect -- Evaluation of Diagnostic Tests -- Genetic Epidemiology of Complex Phenotypes -- Qualitative Research in Clinical Epidemiology -- Evidence Based Decision Making 1: Critical Appraisal -- Evidence Based Decision Making 2: Systematic Review and Meta-Analysis -- Evidence-Based Decision Making 3: Health Technology Assessment -- Evidence-Based Decision Making 4: Clinical Practice Guidelines -- Evidence-Based Decision Making 5: Knowledge Translation and the Knowledge to Action Cycle -- Evidence-Based Decision Making 6: Administrative Databases as Secondary Data Source for Epidemiologic and Health Service Research -- Methods in Evidence-Based Decision Making 7: Health Economics in Clinical Research -- Methods in Evidence-Based Decision Making 8: A Primer for Researchers -- Changing Health-Related Behaviors 1: Patient-Oriented Research and Patient Engagement in Health Research -- Changing Health-Care Behaviors 2: On Improving the Value of Health Spending -- Changing Health-Related Behaviors 3: Lessons from Implementation Science -- Changing Health-Related Behaviors 4: Realizing Impact of Health Research through Knowledge Translation -- Changing Health-Related Behaviors 5: On Interventions to Change Physician Behaviors -- Changing Health-Related Behaviors 6: Analysis, Interpretation, and Application of Big Data Summary This third edition volume expands on the previous editions with updated chapters on longitudinal studies, randomized trials, evidence-based decisions making, and a new section on changing health-related behaviors. The chapters in this book are organized into six parts: Part One focuses on framing clinical research questions and choosing a suitable design; biases that may occur in clinical research; and the ethics associated with doing conducting research on humans. Parts Two through Four discuss designs, measurements, and analysis that pertain to evaluation of risk in longitudinal studies; assessment of therapy in controlled trials; and evaluation of diagnostic tests. Part Five presents methods used in various components of evidence-based decision-making; and Part Six highlights interventions focused on changing health-related behaviors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of various types of bias, step-by-step, readily reproducible protocols for different research designs, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Clinical Epidemiology: Methods and Protocols, Third Edition is a valuable resource for clinicians and researchers who want to expand their works to humans and use their findings in the health system Notes Online resource; title from PDF title page (SpringerLink, viewed April 27, 2021) Subject Epidemiology. Epidemiology -- Methodology Epidemiology Epidemiology Epidemiology -- Methodology Form Electronic book Author Parfrey, Patrick S., editor. Barrett, Brendan, editor. ISBN 9781071611388 1071611380

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