| Description |
1 online resource (508 p.) |
| Contents |
Intro -- Title page -- Table of Contents -- Copyright -- List of contributors -- Chapter 1. History and definitions of ncRNAs -- The C-value paradox-there is more to a genome than protein-coding genes -- Protein synthesis, splicing, and RNA with catalytic function-the early days of ncRNA research -- Pervasive transcription -- Small ncRNAs -- Medium ncRNAs -- Long non-coding RNAs -- Conclusions -- Chapter 2. Regulatory non-coding RNAs-biogenesis, mechanisms of action and role in gene expression regulation -- Introduction -- microRNAs (miRNAs) -- Small interfering RNAs (siRNAs) |
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Long non-coding RNAs (lncRNAs) -- Enhancer RNAs (eRNAs) -- Circular RNAs (circRNAs) -- Piwi RNAs (piRNAs) -- Vault RNAs (vRNAs) -- Concluding remarks -- Chapter 3. Non-coding RNAs: Mechanisms of action -- MicroRNAs -- PIWI-interacting RNAs -- Small nucleolar RNAs -- Small nuclear RNAs -- tRNA-derived fragments -- Long non-coding RNAs -- Circular RNAs -- Enhancer RNAs -- CRediT author statement -- Chapter 4. Functional characterization of lncRNAs -- Introduction -- Genomic features -- Transcriptomic features -- Subcellular localization -- Interacting partners (RNA/DNA/protein) -- RNA structure |
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Perturbation experiments followed by phenotypic assessment -- High-throughput functional screening -- Outlook -- Chapter 5. Secondary structural characterization of non-coding RNAs -- Introduction -- In silico approaches for the characterization of non-coding RNA secondary structure -- Experimental approaches for the characterization of non-coding RNA secondary structure -- Example analysis of the human H19 long noncoding RNA -- Conclusion -- Author contributions -- Chapter 6. Regulation of non-coding RNAs -- Introduction -- Transcriptional regulation of ncRNAs |
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Identification of promoter regions for miRNAs and lncRNAs -- Epitranscriptomic regulation of non-coding RNA -- A-to-I editing -- Funding -- Chapter 7. Non-coding RNAs in human non-infectious diseases -- Introduction -- Aberrant regulation of non-coding RNAs in rheumatoid arthritis -- Dysregulation of non-coding RNA in systemic lupus erythematosus -- Conclusions and perspectives: autoimmune and inflammatory diseases -- Cardiac and skeletal muscle -- Disease of cardiac muscle -- Atrophic conditions in skeletal muscle -- Conclusions and perspectives: cardiac and skeletal muscle diseases |
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Chapter 8. Non-coding RNAs in human infectious diseases -- Introduction -- Biogenesis of non-coding RNA -- Innate immune response elicited by pathogens -- Non-coding RNAs in viral infections -- Non-coding RNAs in bacterial infections -- Non-coding RNAs in other infections -- Predisposition to infectious diseases due to genetic polymorphism -- Non-coding RNAs as therapeutics for infectious diseases -- Conclusion -- Chapter 9. Therapeutic targeting non-coding RNAs -- Introduction -- Non-coding RNA-based therapeutics -- Conclusions and perspectives -- Index |
| Notes |
Description based upon print version of record |
| Form |
Electronic book
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| ISBN |
9780323907002 |
|
0323907008 |
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