Description |
1 online resource (ix, 243 pages) : illustrations |
Series |
Critical reviews in combinatorial chemistry |
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Critical reviews in combinatorial chemistry.
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Contents |
Application of parallel synthesis to the optimization of inhibitors of the ZipA-FtsZ protein-protein interaction / Lee D. Jennings -- Case studies of parallel synthesis in hit identification, hit exploration, hit-to-lead, and lead optimization programs / Alexander Ernst and Daniel Obrecht -- A successful application of parallel synthesis to computer-assisted structural optimization of new leads targeting human immunodeficiency virus-1 reverse transcriptase : the case of acylthiocarbamates and thiocarbamates / Angelo Ranise, Andrea Spallarossa, and Sara Cesarmni -- How high-throughput medicinal chemistry can expedite lead discovery, lead optimization, and beyond / Rongshi Li -- Rapid lead identification of inhibitors of adenine nucleotide translocase : a case study of applying combinatorial chemistry techniques in drug discovery / Yazhong Pei, Walter H. Moos, and Soumitra Ghosh -- Parallel synthesis of anticancer, antiinflammatory, and antiviral agents derived from L- and D-amino acids / Robert C. Reid and David P. Fairlie -- Application of solid-phase parallel synthesis in lead optimization studies / Bijoy Kundu -- High-throughput solid-phase synthesis of nucleoside-based libraries in the search for new antibiotics / Dianqing Sun and Richard E. Lee |
Summary |
Describes the application of parallel synthesis towards lead optimization as well as the design and synthesis of targeted libraries. This book reflects the shift toward conducting parallel lead optimization in-house while outsourcing most of the screening libraries synthesis |
Bibliography |
Includes bibliographical references and index |
Notes |
Print version record |
Subject |
High throughput screening (Drug development)
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Combinatorial chemistry.
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Drug development.
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Drugs -- Design.
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Gene libraries.
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Combinatorial Chemistry Techniques
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Drug Design
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Databases, Genetic
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Gene Library
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Genomic Library
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MEDICAL -- Drug Guides.
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MEDICAL -- Pharmacology.
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MEDICAL -- Pharmacy.
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MEDICAL -- Nursing -- Pharmacology.
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Gene libraries
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Drugs -- Design
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Combinatorial chemistry
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Drug development
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High throughput screening (Drug development)
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Arzneimittelforschung
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High throughput screening
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Kombinatorische Synthese
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Form |
Electronic book
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Author |
Kshirsagar, Tushar.
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ISBN |
9781420006964 |
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1420006967 |
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