| Description |
1 online resource |
| Contents |
Intro -- Contents -- Contributors -- 1: Epidemiology -- 1.1 Incidence and Time Trends -- 1.2 Risk Factors -- 1.2.1 Reproductive and Hormonal Factors -- 1.2.2 Health Behaviors and Environmental Factors -- 1.2.3 Race -- 1.2.4 Genetic Risk Factors -- 1.3 Features of Breast Cancer in Young Women -- 1.3.1 Stage, Grade, and Tumor Subtypes -- 1.3.2 Independent Risk of Young Age -- 1.3.3 Unique Treatment -- 1.3.4 Adherence -- 1.4 Special Considerations for Young Women -- 1.5 Summary -- References -- 2: Young Age and Breast Cancer Biology -- 2.1 Introduction |
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2.2 Gene Expression Profiling -- 2.2.1 Enrichment of Basal-Like Tumors in Young Women -- 2.2.2 Unique Transcriptomic Alterations in Young Women -- 2.3 Germline BRCA Mutation and the Interplay with PgR and RANKL Signaling -- 2.3.1 Germline BRCA Mutation in Young Breast Cancer Patients -- 2.3.2 PgR and BRCA Crosstalk -- 2.3.3 RANKL Regulates PgR Signaling and Is Implicated in BRCA-Related Tumors -- 2.4 Copy Number Alterations According to Age -- 2.5 Higher Frequency of GATA3 Mutations in Young Women with Breast Cancer -- 2.6 Pregnancy Modulates Breast Cancer Biology |
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2.7 Translating Biological Knowledge into Improving Patient Care -- References -- 3: Imaging to Improve Diagnosis of Breast Cancer in Young Women -- 3.1 Introduction -- 3.2 Specific Imaging Characteristics in Young Women with Breast Cancer -- 3.3 Breast Density -- 3.4 Sonography -- 3.5 Mammography -- 3.6 MRI -- 3.7 Pregnant and Lactating Women -- 3.8 Conclusion -- References -- 4: Establishing a Program for Young Women at High Risk for Breast Cancer -- 4.1 Defining the "High-Risk Patient": Risk Factors and Risk Categories -- 4.1.1 Non-genetic Risk Factors for Breast Cancer |
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4.1.1.1 Age -- 4.1.1.2 Environmental and Lifestyle Risk Factors -- 4.1.1.3 Mammographic Breast Density -- 4.1.1.4 Breast Pathology -- 4.1.2 Genetic Risk Factors for Breast Cancer -- 4.1.2.1 Personal History of Breast Cancer -- 4.1.2.2 Family History of Breast Cancer -- 4.1.2.3 Genetic Predisposition -- 4.2 Genetic Counseling and Breast Cancer Risk Assessment Models -- 4.3 Cancer Genetic Risk Assessment -- 4.4 Genetic Test Results -- 4.5 Why Is Genetic Testing Important? -- 4.5.1 Implications for the Affected Individuals -- 4.5.1.1 Implications on the Systemic Therapy Options |
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4.5.1.2 Implications on the Surgical Interventions -- 4.5.2 Implications for the Unaffected Individuals -- 4.5.3 Implications for the Family Members -- 4.6 How to Establish a Program for Young Women at High Risk for Breast Cancer -- References -- 5: Locoregional Management of Hereditary Breast Cancer -- 5.1 Introduction -- 5.2 Breast Cancer Diagnosis and Testing for BRCA Mutation Status: Clinical Scenarios -- 5.2.1 Diagnosis of a Breast Cancer in a Known Mutation Carrier -- 5.2.2 Detection of a Mutation Carrier Status After Completion of Breast Cancer Treatment |
| Summary |
This contributed book covers all aspects concerning the clinical scenario of breast cancer in young women, providing physicians with the latest information on the topic. Young women are a special subset of patients whose care requires dedicated expertise. The book, written and edited by internationally recognized experts who have been directly involved in the international consensus guidelines for breast cancer in young women, pays particular attention to how the disease and its planned treatment can be effectively communicated to young patients. Highly informative and carefully structured, it provides both theoretical and practice-oriented insight for practitioners and professionals involved in the different phases of treatment, from diagnosis to intervention, to follow-up - without neglecting the important role played by prevention |
| Notes |
5.2.3 Suspicion of a Mutation Carrier Status at the Time of Diagnosis of a New Breast Cancer |
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Online resource; title from digital title page (viewed on February 28, 2020) |
| Subject |
Breast -- Cancer.
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Breast Neoplasms
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Breast -- Cancer
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| Form |
Electronic book
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| Author |
Gentilini, Oreste Davide, editor.
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Partridge, Ann (Ann H.), editor.
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Pagani, Olivia, editor.
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| ISBN |
3030247627 |
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9783030247621 |
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