| Description |
1 online resource (1 PDF file (xviii, 733 pages)) : illustrations |
| Series |
Methods in molecular biology, 1940-6029 ; v. 2055 |
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Methods in molecular biology (Clifton, N.J.) ; v. 2055. 1064-3745
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| Contents |
Part I: Scientific Questions and the Status of Inhibitory Receptors for Immunotherapy 1. Status of Immune-oncology: Challenges and Opportunities Alessandra Cesano, Francesco M Marincola, and Magdalena Thurin 2. Immunological Targets for Immunotherapy: Inhibitory T Cell Receptors Diwakar Davar and Hassane M. Zarour Part II : Mutational and Germline Profiling 3. Measuring Tumor Mutational Burden Using Whole Exome Sequencing Tomas Vilimas 4. Germline Genetics in Immuno-Oncology: From Genome-wide to Targeted Biomarker Strategies Tomas Kirchhoff and Robert Ferguson 5. Detection of Microsatellite Instability Biomarkers via Next-generation Sequencing Russell Bonneville, Melanie A. Krook, Hui-Zi Chen, Amy Smith, Eric Samorodnitsky, Michele R. Wing, Julie W. Reeser, and Sameek Roychowdhury 6. Genetic Instability Markers in Cancer Giuseppe Palmieri, Milena Casula, Antonella Manca, Grazia Palomba, Maria Cristina Sini, Valentina Doneddu, Antonio Cossu, and Maria Colombino 7. Validation of Circulating Tumor DNA Assays for Detection of Metastatic Melanoma Mahrukh M Syeda, Jennifer M. Wiggins, Broderick Corless, Cindy Spittle, George Karlin-Neumann, and David Polsky 8. Techniques Associated with Exosome Isolation for Biomarker Development -- Liquid Biopsies for Ovarian Cancer Detection Shayna Sharma and Carlos Salomon Part III: Epigenetic Profiling 9. Identifying MicroRNA Pathway Variants as Biomarkers of Patient Selection for Immune Therapy Joanne B. Weidhaas 10. Histone Modifications as Biomarkers for Immunotherapy Erin M. Taylor, Brian Koss, Lauren E. Davis, and Alan J. Tackett Part IV: Functional Genomic Profiling 11. Functional Genome Profiling to Understand Cancer Immune Responsiveness Ena Wang, Davide Bedognetti, and Francesco M Marincola 12. Using RNA-sequencing to Characterize the Tumor Microenvironment Smith CC, Bixby LM, Miller KL, Selitsky SR, Bortone DS, Hoadley KA, Vincent BG, and Serody JS 13. Development of Gene Expression Based Biomarkers on the nCounter® Platform for Immuno-Oncology Applications Sarah Warren, Patrick Danaher, Afshin Mashadi-Hossein, Lynell Skewis, Brett Wallden, Sean Ferree, and Alessandra Cesano 14. The CRISPR System and Cancer Immunotherapy Biomarkers Vitaly Balan and Jianbin Wang Part V: Phenotyping of Tumor and Immune Cells 15. HLA Class I Antigen Processing Machinery Defects in Cancer Cells -- Frequency, Functional Significance and Clinical Relevance with Special Emphasis on their Role in T cell-based Immunotherapy of Malignant Disease Barbara Seliger and Soldano Ferrone 16. High-parameter Immune Profiling with CyTOF Bita Sahaf, Adeeb Rahman, Holden T. Maecker, and Sean Bendall 17. The Adaptome as Biomarker for Assessing Cancer Immunity and Immunotherapy Jian Han and Michael T. Lotze 18. Single Molecule Arrays for Ultrasensitive Detection of Blood-based Biomarkers for Immunotherapy Limor Cohen, Alissa Keegan, and David R Walt 19. Single-cell Multiplexed Proteomics on the IsoLight Resolves Cellular Functional Heterogeneity to Reveal Clinical Responses of Cancer Patients to Immunotherapies Dong Liu, Patrick Paczkowski, Sean Mackay, Colin Ng, and Jing Zhou 20. Methods to Detect Immunogenic Cell Death in vivo Takahiro Yamazaki, Aitziber Buqué Martinez, Marissa Rybstein, Jonathan Chen, Ai Sato, and Lorenzo Galluzzi Part VI: Tissue Imaging Methods 21. Overview of Tissue Imaging Methods Sanjay S. Patel and Scott J. Rodig 22. Multiplex Immunofluorescence Assays Alejandro Francisco-Cruz, Edwin Roger Parra, Michael T. Tetzlaff, and Ignacio I. Wistuba, 23. Multiplexed Immunohistochemical Consecutive Staining on Single Slide (MICSSS): Multiplexed Chromogenic IHC Assay for High-Dimensional Tissue Analysis Guray Akturk, Robert Sweeney, Romain Remark, Miriam Merad, and Sacha Gnjatic 24 Cyclic Multiplexed-Immunofluorescence (cmIF), A Highly Multiplexed Method for Single-cell Analysis Jennifer Eng, Guillaume Thibault, Shiuh-Wen Luoh, Joe W. Gray, Young Hwan Chang, and Koei Chin 25. High-Plex Spatially Resolved RNA and Protein Detection using Digital Spatial Profiling: A Technology Designed for Immuno-Oncology Biomarker Discovery and Translational Research Joseph M. Beechem 26. The InSituPlex® Staining Method for Multiplexed Immunofluorescence Cell Phenotyping and Spatial Profiling of Tumor FFPE Samples Mael Manesse, Katir K. Patel, Sean R. Downing, and Mark Bobrow Part VII: Microbiome 27. Microbiome as an Immunological Modifier Manoj Kumar, Parul Singh, Selvasankar Murugesan, Marie Vetizou, John McCulloch, Jonathan H. Badger, Giorgio Trinchieri, and Souhaila Al Khodor Part VIII: System Biology for Multi-platform Data Integration 28. Systems Biology for Multi-Platform Data Integration -- Overview Elad Ziv 29. Bioinformatics Tools and Resources for Cancer Immunotherapy Study Alida Palmisano, Julia Krushkal, Ming-Chung Li, Jianwen Fang, Dmitriy Sonkin, George Wright, Laura Yee, Yingdong Zhao, Lisa McShane 30. Multiplatform Integrative Analysis of Immunogenomic Data for Biomarker Discovery Vésteinn Thorsson Part IX: Regulatory Perspective 31. Translating Immuno-Oncology Biomarkers to Diagnostic tests: A Regulatory Perspective You Li, Janaki Veeraraghavan, and Reena Philip |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed January 25, 2021) |
| Subject |
Cancer -- Immunotherapy.
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Biochemical markers.
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Tumor markers.
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Neoplasms -- therapy
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Immunotherapy -- methods
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Biomarkers, Tumor
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Computational Biology -- methods
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Biomarkers
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Tumor markers
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Biochemical markers
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Cancer -- Immunotherapy
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| Genre/Form |
Laboratory manuals
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Laboratory manuals.
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Manuels de laboratoire.
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| Form |
Electronic book
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| Author |
Thurin, Magdalena, editor
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Cesano, Alessandra, editor
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Marincola, Francesco M., editor
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| ISBN |
9781493997732 |
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1493997734 |
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