| Description |
1 online resource (427 p.) |
| Contents |
Cover -- Title Page -- Copyright Page -- About the Editors -- Historical Development and Perspectives of the Series -- Preface to Volume 27 -- Table of Contents -- Contributors to Volume 27 -- Handbooks and Book Series Published and (Co-)edited by the SIGELs -- Chapter 1 Synthesis and Characterization of Ligands and their Gd(III) Complexes -- 1 Introduction -- 2 Physicochemical Properties of GBCAs: Thermodynamic, Inertness, and Relaxometry -- 3 "DOTA-like" Derivatives and Related DOTA-Compounds Based on the Cyclen Platform -- 3.1 Ways to Improve "DOTA" |
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3.1.1 Number of Water Molecules in the First Coordination Sphere of the Metal Ion -- 3.1.2 Improvement of the Rotational Correlation Time of DOTA Derivatives -- 3.1.3 Residence Time in the First Coordination Sphere -- 3.2 DO3A and DO3A-Based Derivatives -- 3.2.1 DO3A and DO3A-Based Derivatives Synthesis -- 3.2.2 DO3A and DO3A-Based Derivatives Properties -- 3.3 DO2A or DO2PA Derivatives -- 3.3.1 DO2A or DO2PA Derivatives Synthesis -- 3.3.2 DO2A or DO2PA Derivative Properties -- 4 Cyclen-Based Gd[sup(3+)] Chelators with 4 Identical Pendant Arm Other Than Acetate -- 4.1 Synthesis -- 4.2 Properties |
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5 Backbon-Modified DOTA Derivatives -- 6 13-4-Ane and Cyclam Derivatives -- 7 Tacn-Based Gadolinium(III) Chelators -- 7.1 Synthesis -- 7.2 Thermodynamic Stability -- 7.3 Relaxivity -- 8 Pyclen-Based Chelators as GBCAs -- 8.1 H[sub(3)]PCTA: The Archetype of Pyclen-Based Chelators -- 8.1.1 Synthesis -- 8.1.2 Physicochemical and Relaxometric Properties of [Gd(PCTA)] -- 8.2 PCTA Derivatives -- 8.2.1 Synthesis of PCTA Derivatives -- 8.2.2 Thermodynamic and Kinetic Stability -- 8.2.3 Relaxometric Properties -- 9 Conclusion -- Abbreviations and Definitions -- References |
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Chapter 2 PARASHIFT Systems: Including [sup(19)]F Effects -- 1 Introduction -- 1.1 Sensitivity Limitations of Traditional MR Chemical Shift Approaches -- 1.2 Overcoming the MR Sensitivity Limitation -- 2 Effects of Paramagnetic Ions on Magnetic Resonance -- 2.1 Chemical Shift -- 2.2 Relaxation -- 3 Ln(III)-Based PARASHIFT Agents -- 3.1 Ln(III)-Based [sup(19)]F PARASHIFT Systems -- 3.2 Ln(III)-Based [sup(1)]F PARASHIFT Systems -- 3.3 Applications of Ln(III) PARASHIFT Systems -- 3.3.1 Temperature Sensitivity -- 3.3.2 pH-Responsive Probes -- 3.3.3 Ion-Responsive Probes |
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3.3.4 Enzyme-Responsive Probes -- 4 Transition Metal-Based PARASHIFT Agents -- 4.1 TM-Based [sup(19)]F PARASHIFT Systems -- 4.2 TM-Based [sup(1)]H PARASHIFT Systems -- 4.3 Applications of TM-Based PARASHIFT Systems -- 4.3.1 Temperature Sensitivity -- 4.3.2 pH-Responsive Probes -- 4.3.3 Redox Active Probes -- 4.3.4 Spin State-Responsive Probes -- 5 Concluding Remarks and Future Directions -- Abbreviations and Definitions -- References -- Chapter 3 Targeted MRI Contrast Agents -- 1 Introduction -- 2 Tumors -- 2.1 General Tumor Targeting -- 2.1.1 Enhanced Permeability and Retention Effect |
| Summary |
The diagnostic application of MRI Contrast agents, both in the form of Gd3+ and transition metal complexes, like Mn at different oxidation states, as well as of nanomaterials, such as iron oxides, ferrites and Ln3+ salts, including their theranostic potential, is described in detail |
| Notes |
Description based upon print version of record |
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2.1.2 Epidermal Growth Factor Receptor |
| Subject |
Rare earth metals -- Magnetic properties.
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Nanoparticles -- Diagnostic use
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Iron oxides.
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Magnetic resonance imaging.
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| Form |
Electronic book
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| ISBN |
9781040098806 |
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1040098800 |
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